KEGG   ENZYME: 3.5.1.95Help
Entry
EC 3.5.1.95                 Enzyme                                 

Name
N-malonylurea hydrolase;
ureidomalonase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming)
Reaction(IUBMB)
3-oxo-3-ureidopropanoate + H2O = malonate + urea [RN:R07629]
Reaction(KEGG)
R07629;
(other) R10778
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Substrate
3-oxo-3-ureidopropanoate [CPD:C15607];
H2O [CPD:C00001]
Product
malonate [CPD:C00383];
urea [CPD:C00086]
Comment
Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.2.1 (barbiturase).
History
EC 3.5.1.95 created 2006
Pathway
Pyrimidine metabolism
Orthology
K19795  
ureidomalonase
Genes
RHA: 
RER: 
REY: 
REB: 
ROP: 
ROA: 
SEN: 
Taxonomy
Reference
1  [PMID:11485332]
  Authors
Soong CL, Ogawa J, Shimizu S.
  Title
Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase.
  Journal
Biochem. Biophys. Res. Commun. 286 (2001) 222-6.
Reference
2  [PMID:11748240]
  Authors
Soong CL, Ogawa J, Sakuradani E, Shimizu S.
  Title
Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism.
  Journal
J. Biol. Chem. 277 (2002) 7051-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
368888-22-6

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