maleimide hydrolase;
imidase;
cyclic imide hydrolase;
cyclic-imide amidohydrolase (decyclicizing) [misprint]

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides

cyclic-imide amidohydrolase (decyclizing)

maleimide + H2O = maleamic acid [RN:R05781]

R05781

maleimide [CPD:C07272];
H2O [CPD:C00001]

Succinimide and glutarimide, and sulfur-containing cyclic imides, such as rhodanine, can also act as substrates for the enzyme from Blastobacter sp. A17p-4. The reverse, cyclization, reaction is also catalysed, but much more slowly. It has lower activity towards cyclic ureides, which are the substrates of EC 3.5.2.2, dihydropyrimidinase.

1  [PMID:9030755]

Ogawa J, Soong CL, Honda M, Shimizu S.

Imidase, a dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides.

Eur. J. Biochem. 243 (1997) 322-7.

Blastobacter sp.