KEGG   ENZYME: 3.5.2.18Help
Entry
EC 3.5.2.18                 Enzyme                                 

Name
enamidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
BRITE hierarchy
Sysname
6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase
Reaction(IUBMB)
6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O = 2-formylglutarate + NH3 [RN:R07984]
Reaction(KEGG)
Substrate
6-oxo-1,4,5,6-tetrahydronicotinate [CPD:C04226];
H2O [CPD:C00001]
Product
2-formylglutarate [CPD:C16159];
NH3 [CPD:C00014]
Comment
Contains iron and Zn2+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 1.1.1.291 (2-hydroxymethylglutarate dehydrogenase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).
History
EC 3.5.2.18 created 2006
Pathway
Nicotinate and nicotinamide metabolism
Orthology
K15358  
enamidase
Genes
BXE: 
BPY: 
BUG: 
BGF: 
POL: 
VEI: 
VAP: 
VPE: 
MCI: 
MOP: 
BJA: 
BRA: 
BBT: 
RPB: 
XAU: 
AZC: 
BSB: 
SIL: 
RDE: 
MAG: 
TEP: 
NTH: 
MSM: 
SAQ: 
CWO: 
IPO: 
TRO: 
MCJ: 
 » show all
Taxonomy
Reference
1  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 12341-6.
  Sequence
[up:Q0QLE9]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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