KEGG   ENZYME: 3.5.2.18Help
Entry
EC 3.5.2.18                 Enzyme                                 

Name
enamidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
BRITE hierarchy
Sysname
6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase
Reaction(IUBMB)
6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O = 2-formylglutarate + NH3 [RN:R07984]
Reaction(KEGG)
Substrate
6-oxo-1,4,5,6-tetrahydronicotinate [CPD:C04226];
H2O [CPD:C00001]
Product
2-formylglutarate [CPD:C16159];
NH3 [CPD:C00014]
Comment
Contains iron and Zn2+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 1.1.1.291 (2-hydroxymethylglutarate dehydrogenase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).
History
EC 3.5.2.18 created 2006
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K15358  enamidase
Genes
GAI: IMCC3135_06255(ena)
BUG: BC1001_4282
BGF: BC1003_5118
BUQ: AC233_28060
BUZ: AYM40_31820
BXE: Bxe_B0661
BXB: DR64_5992(ena)
BPX: BUPH_00866
BPY: Bphyt_4330
BFN: OI25_6348
BTRM: SAMEA390648703552(Ena)
POL: Bpro_4072
VEI: Veis_0850
BJA: bll3830
BRA: BRADO2124
BBT: BBta_2433
BRS: S23_44100
AOL: S58_54100
BRAD: BF49_1213
RPB: RPB_1671
XAU: Xaut_4206
AZC: AZC_2804
HDI: HDIA_4511(Ena)
SIL: SPO0819
RDE: RD1_1529
OTM: OSB_05860
GXL: H845_1049
MAG: amb1486
CPAT: CLPA_c02940(ena)
CPAE: CPAST_c02940(ena)
TAE: TepiRe1_0451(Ena) TepiRe1_0461(Ena)
MVQ: MYVA_2367
SAQ: Sare_0577
CWO: Cwoe_3945
TRO: trd_A0335
 » show all
Taxonomy
Reference
1  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 12341-6.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.2.18
IUBMB Enzyme Nomenclature: 3.5.2.18
ExPASy - ENZYME nomenclature database: 3.5.2.18
BRENDA, the Enzyme Database: 3.5.2.18

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