KEGG   ENZYME: 3.5.2.19Help
Entry
EC 3.5.2.19                 Enzyme                                 

Name
streptothricin hydrolase;
sttH (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
BRITE hierarchy
Sysname
streptothricin-F hydrolase
Reaction(IUBMB)
streptothricin-F + H2O = streptothricin-F acid [RN:R09657]
Reaction(KEGG)
Substrate
streptothricin F [CPD:C19785];
H2O [CPD:C00001]
Product
streptothricin F acid [CPD:C19786]
Comment
The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2].
History
EC 3.5.2.19 created 2011
Reference
1  [PMID:19897889]
  Authors
Maruyama C, Hamano Y
  Title
The biological function of the bacterial isochorismatase-like hydrolase SttH.
  Journal
Biosci. Biotechnol. Biochem. 73 (2009) 2494-500.
  Sequence
Reference
2  [PMID:16641084]
  Authors
Hamano Y, Matsuura N, Kitamura M, Takagi H
  Title
A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific.
  Journal
J. Biol. Chem. 281 (2006) 16842-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system