KEGG   ENZYME: 3.5.3.26Help
Entry
EC 3.5.3.26                 Enzyme                                 

Name
(S)-ureidoglycine aminohydrolase;
UGlyAH;
UGHY;
ylbA (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
BRITE hierarchy
Sysname
(S)-ureidoglycine aminohydrolase
Reaction(IUBMB)
(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH3 [RN:R05554]
Reaction(KEGG)
Substrate
(S)-2-ureidoglycine;
H2O [CPD:C00001]
Product
(S)-ureidoglycolate [CPD:C00603];
NH3 [CPD:C00014]
Comment
Binds Mn2+. This enzyme, found in plants and bacteria, is part of the ureide pathway, which enables the recycling of the nitrogen in purine compounds. In plants it is localized in the endoplasmic reticulum.
History
EC 3.5.3.26 created 2013
Pathway
ec00230  Purine metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K14977  (S)-ureidoglycine aminohydrolase
Genes
RSS: 109442711
ATH: AT4G17050(UGLYAH)
ALY: ARALYDRAFT_493171
CRB: 17880024
CSAT: 104718647 104723399 104731876
EUS: EUTSA_v10026866mg
BRP: 103860892 103868931
BNA: 106425359 106437389 106440141 106440260
BOE: 106303721 106344891
THJ: 104807929
CPAP: 110810863
CIT: 102624772
TCC: 18606154
GRA: 105765058
GHI: 107946699
DZI: 111315163
EGR: 104441965
VRA: 106769133
VAR: 108319681
CCAJ: 109811810
CAM: 101499522
ADU: 107484713
AIP: 107629124
LJA: Lj0g3v0272899.1(Lj0g3v0272899.1) Lj0g3v0272899.2(Lj0g3v0272899.2)
LANG: 109331682
FVE: 101309352
PPER: 18777393
PMUM: 103342603
PAVI: 110756484
PXB: 103937908
ZJU: 107430343
CSV: 101218090
CMO: 103491151
MCHA: 111022624
CMAX: 111498454
CMOS: 111454479
CPEP: 111800312
RCU: 8269033
JCU: 105632356
SLY: 101248901
SPEN: 107026852
SOT: 102579476
CANN: 107868552
NSY: 104224652
NTO: 104106488
INI: 109174807
SIND: 105178742
OEU: 111372362
HAN: 110922124
LSV: 111907387
DCR: 108209423
BVG: 104892831
SOE: 110781772
NNU: 104606373
OSA: 4343286
DOSA: Os07t0495000-01(Os07g0495000)
OBR: 102715318
BDI: 100839183
ATS: 109763127(LOC109763127)
SBI: 8077471
ZMA: 100217019
SITA: 101757632
PDA: 103710779
EGU: 105043786
MUS: 103984459
DCT: 110105240
AOF: 109838862
ATR: 18429130
PPP: 112286678
CRE: CHLREDRAFT_34332(GIP1)
MNG: MNEG_6401
APRO: F751_2384
MAW: MAC_04358
MAJ: MAA_02873
ECO: b0515(allE)
ECJ: JW0503(ylbA)
ECD: ECDH10B_0471(ylbA)
EBW: BWG_0391(ylbA)
ECOK: ECMDS42_0408(ylbA)
ECE: Z0670(ylbA)
ECS: ECs0577
ETW: ECSP_0589(ylbA)
EOJ: ECO26_0548(ylbA)
EOI: ECO111_0547(ylbA)
EOH: ECO103_0487(ylbA)
ECG: E2348C_0448(ylbA)
EOK: G2583_0635(ylbA)
ECC: c0629(ylbA)
ECP: ECP_0575
ECI: UTI89_C0543(ylbA)
ECV: APECO1_1500(ylbA)
ECY: ECSE_0540
ECR: ECIAI1_0517(ylbA)
ECQ: ECED1_0534(ylbA)
ECK: EC55989_0529(ylbA)
ECT: ECIAI39_0478(ylbA)
EOC: CE10_0489(ylbA)
EUM: ECUMN_0555(ylbA)
ECZ: ECS88_0514(ylbA)
ELH: ETEC_0567
ESE: ECSF_0477
ESO: O3O_06370
ESM: O3M_18900
ESL: O3K_18925
EBR: ECB_00465(ylbA)
EBD: ECBD_3143
EAB: ECABU_c05940(ylbA)
EDJ: ECDH1ME8569_0499(ylbA)
ENA: ECNA114_0492(ylbA)
ELW: ECW_m0586(ylbA)
ELL: WFL_02905
ELC: i14_0605(ylbA)
ELD: i02_0605(ylbA)
EBL: ECD_00465(allE)
EBE: B21_00470(ylbA)
ELF: LF82_3524(ylbA)
ECOI: ECOPMV1_00503(ylbA)
ECOJ: P423_02620
ECOO: ECRM13514_0321(ylbA)
ECOH: ECRM13516_0504(ylbA)
ECOS: EC958_0653(ylbA)
STY: STY0574
STT: t2335
STM: STM0526(ylbA)
SEO: STM14_0616(ylbA)
SEY: SL1344_0519(ylbA)
SEJ: STMUK_0533(ylbA)
SPT: SPA2197(ylbA)
SEK: SSPA2042
SEI: SPC_0540(ylbA)
SEC: SCH_0565(ylbA)
SHB: SU5_01219
SENS: Q786_02595
SED: SeD_A0574
SEG: SG0538(ylbA)
SEL: SPUL_2434
SET: SEN0507(ylbA)
SENA: AU38_02585
SENO: AU37_02580
SENV: AU39_02585
SENQ: AU40_02840
SENL: IY59_02635
SEEP: I137_11095
SENB: BN855_5250
SENE: IA1_02775
SFL: SF0449(ylbA)
SFX: S0457(ylbA)
SFV: SFV_0476(ylbA)
SFN: SFy_0572
SFS: SFyv_0610
SFT: NCTC1_00463(ylbA)
KPU: KP1_1371
KPP: A79E_3792
YIN: CH53_63
SMAR: SM39_0492
SERF: L085_22970
RAA: Q7S_01490
MHAT: B824_16620
MHAM: J450_02310
MVE: X875_8740
PAE: PA1140
PAEV: N297_1180
PAEI: N296_1180
PAU: PA14_49650(ylbA)
PNC: NCGM2_2012(ylbA)
PAEB: NCGM1900_1455(ylbA)
PAEP: PA1S_20185
PAEM: U769_20060
PAEL: T223_21360
PAEU: BN889_01214(ylbA)
PAEG: AI22_13765
PAEC: M802_1176
PAEO: M801_1180
PMY: Pmen_1325
PMK: MDS_1354
PPSE: BN5_3034
PPU: PP_3530(allE)
PPF: Pput_2243
PPT: PPS_3024
PPI: YSA_00055
PPX: T1E_0015
PPUH: B479_15040
PPUT: L483_18490
PPUN: PP4_23070
PPUD: DW66_3293
PMON: X969_14495
PMOT: X970_14140
PFL: PFL_3803
PPRO: PPC_3902
PEN: PSEEN2925
PSA: PST_2947
PSOS: POS17_3919
PSET: THL1_1773
MHC: MARHY2911
GPS: C427_4927
GAI: IMCC3135_20530(allE)
HCH: HCH_01149
CSA: Csal_0079
HEL: HELO_1600
HAM: HALO1153
HBE: BEI_3026(ylbA)
OCE: GU3_01240
RPI: Rpic_3617
REH: H16_B2457(h16_B2457)
BVE: AK36_3131
BCN: Bcen_5420
BCJ: BCAM2638
BCEN: DM39_5225
BCEW: DM40_3237
BCEO: I35_6532
BAM: Bamb_4787
BMU: Bmul_3330
BMK: DM80_4711
BMUL: NP80_3213
BCT: GEM_5758
BCED: DM42_5339
BDL: AK34_3241
BCON: NL30_16965
BUB: BW23_3827
BLAT: WK25_28775
BTEI: WS51_09930
BSEM: WJ12_33095
BPSL: WS57_01110
BMEC: WJ16_31565
BSTG: WT74_31845
BUK: MYA_3265
BUO: BRPE64_CCDS02760(ylbA)
PPNO: DA70_03515
PPNM: LV28_02800
PPUL: RO07_21700
PSPU: NA29_15435
PAPI: SG18_20635
AMIM: MIM_c01260
MLO: mll5131
MES: Meso_2830
SME: SM_b20684
SMER: DU99_26595
SMD: Smed_4304
SFD: USDA257_c15150(ylbA)
ATU: Atu3205
ARA: Arad_7142
AVI: Avi_5006
RLE: pRL110462
RLG: Rleg_6664
RHT: NT26_2991
SHZ: shn_16330
BME: BMEI1578
BMEL: DK63_1912
BMEE: DK62_1041
BMF: BAB1_0374
BABO: DK55_391
BABR: DO74_1496
BABT: DK49_154
BABB: DK48_1736
BABU: DK53_381
BABS: DK51_1083
BABC: DO78_298
BMS: BR0346
BSZ: DK67_1285
BOV: BOV_0362
BCAR: DK60_438
BCAS: DA85_01680
BMR: BMI_I351
BPP: BPI_I380
BPV: DK65_1001
OAN: Oant_0448
OAH: DR92_2491
BJA: blr0253
BRA: BRADO2840
BBT: BBta_5334
BRS: S23_28400
AOL: S58_47690
RPA: RPA0553
RPT: Rpal_0555
MEX: Mext_1741
MDI: METDI2415
MCH: Mchl_2060
MPO: Mpop_1072
MNO: Mnod_7819
MOR: MOC_3377
META: Y590_08295
PHL: KKY_2244
MMED: Mame_00412
SIL: SPO0876
RSP: RSP_1553
JAN: Jann_2601
RDE: RD1_1128
PDE: Pden_3794
DSH: Dshi_3200
KVU: EIO_0975
KVL: KVU_0492
KRO: BVG79_00757(ylbA)
PSF: PSE_0753
PGD: Gal_02954
OTM: OSB_04190
CID: P73_3912
MALG: MALG_04363
RSU: NHU_01702
RHC: RGUI_3394
RMM: ROSMUCSMR3_02728(allE)
LVS: LOKVESSMR4R_02829(allE)
AHT: ANTHELSMS3_04160(allE)
BLI: BL01096
BLD: BLi01128(ylbA1)
LSP: Bsph_2899
SCA: SCA_2055
LFE: LAF_0162
EFA: EF2996
EFL: EF62_0081
EFS: EFS1_2430
EFN: DENG_02885(ylbA)
EFQ: DR75_1725
ENE: ENT_27400
ECAS: ECBG_00214
CRN: CAR_c17750(ylbA)
CML: BN424_1732(ylbA)
CARC: NY10_822
CSQ: CSCA_5011
DSY: DSY4160
DHD: Dhaf_1181
PUF: UFO1_0276
MGI: Mflv_3172
MVQ: MYVA_3213
GOR: KTR9_1121
TPR: Tpau_2030
ART: Arth_3435
ARR: ARUE_c35460(ylbA)
AAU: AAur_3409
ACH: Achl_3214
KRH: KRH_19830
LMOI: VV02_25750
SERJ: SGUI_3181
BLIN: BLSMQ_0840
NML: Namu_0241
SEN: SACE_7229
PSEE: FRP1_03155
CWO: Cwoe_2420
DRA: DR_1152
DGE: Dgeo_2608
DGO: DGo_PA0232(glxB)
TRA: Trad_1506
MRB: Mrub_1387
MIN: Minf_2339(glxB)
SUS: Acid_0363
CPI: Cpin_6771
HSW: Hsw_2655
 » show all
Taxonomy
Reference
1  [PMID:20038185]
  Authors
Serventi F, Ramazzina I, Lamberto I, Puggioni V, Gatti R, Percudani R
  Title
Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria.
  Journal
ACS. Chem. Biol. 5 (2010) 203-14.
  Sequence
[ath:AT4G17050] [ag:ADH04165]
Reference
2  [PMID:19935661]
  Authors
Werner AK, Romeis T, Witte CP
  Title
Ureide catabolism in Arabidopsis thaliana and Escherichia coli.
  Journal
Nat. Chem. Biol. 6 (2010) 19-21.
  Sequence
[ath:AT4G17050] [eco:b0515]
Reference
3  [PMID:22493446]
  Authors
Shin I, Percudani R, Rhee S
  Title
Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana.
  Journal
J. Biol. Chem. 287 (2012) 18796-805.
  Sequence
[ath:AT4G17050]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.26
IUBMB Enzyme Nomenclature: 3.5.3.26
ExPASy - ENZYME nomenclature database: 3.5.3.26
BRENDA, the Enzyme Database: 3.5.3.26

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