KEGG   ENZYME: 3.5.4.11Help
Entry
EC 3.5.4.11                 Enzyme                                 
Name
pterin deaminase;
acrasinase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
2-amino-4-hydroxypteridine aminohydrolase
Reaction(IUBMB)
a 2-amino-4-hydroxypteridine + H2O = a 2,4-dihydroxypteridine + NH3 [RN:R02815]
Reaction(KEGG)
R02815;
(other) R06137
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Substrate
2-amino-4-hydroxypteridine [CPD:C00715];
H2O [CPD:C00001]
Product
2,4-dihydroxypteridine [CPD:C03212];
NH3 [CPD:C00014]
Comment
The animal enzyme is specific for pterin, isoxanthopterin and tetrahydropterin.
Reference
1  [PMID:13654299]
  Authors
LEVENBERG B, HAYAISHI O.
  Title
A bacterial pterin deaminase.
  Journal
J. Biol. Chem. 234 (1959) 955-61.
  Organism
Alcaligenes metalcaligenes
Reference
2  [PMID:5821022]
  Authors
Rembold H, Simmersbach F.
  Title
Catabolism of pteridine cofactors. II. A specific pterin deaminase in rat liver.
  Journal
Biochim. Biophys. Acta. 184 (1969) 589-96.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-04-1
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