KEGG   ENZYME: 3.5.4.17Help
Entry
EC 3.5.4.17                 Enzyme                                 

Name
adenosine-phosphate deaminase;
adenylate deaminase;
adenine nucleotide deaminase;
adenosine (phosphate) deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
adenosine-phosphate aminohydrolase
Reaction(IUBMB)
(1) AMP + H2O = IMP + NH3 [RN:R00181];
(2) ADP + H2O = IDP + NH3;
(3) ATP + H2O = ITP + NH3
Reaction(KEGG)
Substrate
AMP [CPD:C00020];
H2O [CPD:C00001];
ADP [CPD:C00008];
ATP [CPD:C00002]
Product
IMP [CPD:C00130];
NH3 [CPD:C00014];
IDP [CPD:C00104];
ITP [CPD:C00081]
Comment
Acts on AMP, ADP, ATP, NAD+ and adenosine, in decreasing order of activity. The bacterial enzyme can also accept the deoxy derivatives. cf. EC 3.5.4.6, AMP deaminase.
History
EC 3.5.4.17 created 1972, modified 1980, modified 2014
Reference
1  [PMID:5940938]
  Authors
Su JC, Li CC, Ting CC.
  Title
A new adenylate deaminase from red marine alga Porphyra crispata.
  Journal
Biochemistry. 5 (1966) 536-43.
  Organism
Porphyra crispata
Reference
2  [PMID:5773435]
  Authors
Yates MG.
  Title
A non-specific adenine nucleotide deaminase from desulfovibrio desulfuricans.
  Journal
Biochim. Biophys. Acta. 171 (1969) 299-310.
  Organism
Desulfovibrio desulfuricans
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37289-20-6

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