KEGG   ENZYME: 3.5.4.22Help
Entry
EC 3.5.4.22                 Enzyme                                 

Name
1-pyrroline-4-hydroxy-2-carboxylate deaminase;
HPC deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)
Reaction(IUBMB)
1-pyrroline-4-hydroxy-2-carboxylate + H2O = 2,5-dioxopentanoate + NH3 [RN:R02280]
Reaction(KEGG)
Substrate
1-pyrroline-4-hydroxy-2-carboxylate [CPD:C04282];
H2O [CPD:C00001]
Product
2,5-dioxopentanoate [CPD:C00433];
NH3 [CPD:C00014]
Pathway
Arginine and proline metabolism
Reference
1  [PMID:5845838]
  Authors
Singh RM, Adams E.
  Title
Enzymatic deamination of delta-1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde).
  Journal
J. Biol. Chem. 240 (1965) 4344-51.
  Organism
Pseudomonas striata
Reference
2  [PMID:5845839]
  Authors
Singh RM, Adams E.
  Title
Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline.
  Journal
J. Biol. Chem. 240 (1965) 4352-6.
  Organism
Pseudomonas sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9054-77-7

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