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Entry
EC 3.5.4.22                 Enzyme                                 

Name
1-pyrroline-4-hydroxy-2-carboxylate deaminase;
HPC deaminase;
1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (ring-opening)
Reaction(IUBMB)
1-pyrroline-4-hydroxy-2-carboxylate + H2O = 2,5-dioxopentanoate + NH3 [RN:R02280]
Reaction(KEGG)
Substrate
1-pyrroline-4-hydroxy-2-carboxylate [CPD:C04282];
H2O [CPD:C00001]
Product
2,5-dioxopentanoate [CPD:C00433];
NH3 [CPD:C00014]
History
EC 3.5.4.22 created 1976
Pathway
ec00330  Arginine and proline metabolism
Orthology
K21062  1-pyrroline-4-hydroxy-2-carboxylate deaminase
Genes
EAS: Entas_0543
KPK: A593_14035
KPY: KPNIH31_04600
KPE: KPK_4823
KPI: D364_24435
KVA: Kvar_4456
KVD: KR75_11485
KVQ: SP68_18120
KQU: AVR78_07840
EAE: EAE_10395
EAR: CCG31915
CRO: ROD_25481
SPE: Spro_1838
SRL: SOD_c16640(dapA1)
SPLY: Q5A_009100(dapA_1)
SMAF: D781_1748
SMAR: SM39_1306
SERF: L085_19535
EPY: EpC_10330
EAM: EAMY_2593
EAY: EAM_2488
PLU: plu2245
PAY: PAU_02152(yjhH)
XCC: XCC2411(dapA)
XCB: XC_1701
XCA: xcc-b100_1754(dapA2)
XCP: XCR_2712
XCV: XCV2744(dapA2)
XAX: XACM_2527(dapA2)
XAC: XAC2547(dapA)
XCI: XCAW_02226(dapA)
XFU: XFF4834R_chr25690(dapA2)
XOO: XOO3137(dapA)
XOM: XOO2979(XOO2979)
XOP: PXO_01439
XOR: XOC_1909
XAL: XALC_1962(dapA2)
XPH: XppCFBP6546_19680(XppCFBP6546P_19680)
LEZ: GLE_4608
LEM: LEN_0613
VPA: VP1335
VPB: VPBB_1258
VAG: N646_0369
PAE: PA1254
PAEV: N297_1293
PAEI: N296_1293
PAEP: PA1S_19645
PAEM: U769_19485
PAEL: T223_20735
PAEG: AI22_14320
PAEC: M802_1290
PAEO: M801_1293
PCQ: PcP3B5_24840(dapA_1)
PPU: PP_1257
PPF: Pput_1284
PPT: PPS_3965
PPI: YSA_07694
PPX: T1E_3149
PPUH: B479_19710
PPUN: PP4_11960
PPUD: DW66_4404
PMON: X969_19360
PMOT: X970_18995
PFL: PFL_1413
PPRC: PFLCHA0_c14500(dapA2)
PPRO: PPC_1467
PFS: PFLU_3325
PFB: VO64_0474
PMAN: OU5_0406
PEN: PSEEN4051
PSTT: CH92_01020
PPUU: PputUW4_03028(dapA2)
PSEM: TO66_07020
PSOS: POS17_1436
PANR: A7J50_3072
PSET: THL1_3331
ACB: A1S_1322
ABY: ABAYE2388
ABN: AB57_1505
ABX: ABK1_1771
ABAD: ABD1_13320
ABAZ: P795_10770
ABAU: IX87_03835
ACC: BDGL_000669(dapA)
SAZ: Sama_1531
SLO: Shew_2362
SSE: Ssed_1762
SPL: Spea_1704
SHL: Shal_2555
SWD: Swoo_2822
SWP: swp_1984
SVO: SVI_1710(dapA-1)
SPSW: Sps_03405
SMAV: CFF01_07495(dapA)
CPS: CPS_1449
PTN: PTRA_b0293(dapA)
PTU: PTUN_a1047(dapA)
FBL: Fbal_2400
SAGA: M5M_03820
CSA: Csal_2706
HEL: HELO_1562
HAM: HALO1343
CVI: CV_2825
PSE: NH8B_1449
RME: Rmet_5097
BMA: BMAA1420
BMAE: DM78_4010
BMAI: DM57_08760
BMAF: DM51_5064
BMAZ: BM44_4892
BMAB: BM45_3794
BPS: BPSS0331
BPSE: BDL_3563
BPSM: BBQ_5868
BPSU: BBN_3727
BPSD: BBX_5401
BPK: BBK_5543
BPSH: DR55_5016
BPSA: BBU_5786
BPSO: X996_4785
BUT: X994_4285
BTQ: BTQ_5348
BTJ: BTJ_4000
BTZ: BTL_4824
BTD: BTI_4400
BTV: BTHA_5406
BTHE: BTN_4474
BTHM: BTRA_4740
BTHA: DR62_4588
BTHL: BG87_4805
BOK: DM82_4400
BOC: BG90_3676
BVE: AK36_6011
BCN: Bcen_4227
BCJ: BCAM1266
BCEN: DM39_6469(dapA)
BCEW: DM40_5658(dapA)
BCEO: I35_5114
BAM: Bamb_6107
BMU: Bmul_5988
BMJ: BMULJ_05539(dapA)
BMK: DM80_6437(dapA)
BMUL: NP80_5680
BCED: DM42_3827
BDL: AK34_4214
BCON: NL30_06275
BUB: BW23_4938
BLAT: WK25_18505
BTEI: WS51_29405
BSEM: WJ12_26175
BPSL: WS57_17265
BMEC: WJ16_24805
BSTG: WT74_25120
BGP: BGL_2c02600(dapA1)
BGU: KS03_3367(dapA)
BGO: BM43_7270
BUK: MYA_5974
BUL: BW21_3933
BXE: Bxe_B0873
BXB: DR64_6194
BPH: Bphy_4666
BFN: OI25_6625
AXX: ERS451415_00740(dapA_1)
ODI: ODI_R2964
VEI: Veis_1046
CARE: LT85_0644
MXA: MXAN_6203
MES: Meso_2568
SME: SM_b20259
SMER: DU99_32075
SMD: Smed_3873
SFD: USDA257_c35130(dapA4)
SIX: BSY16_2974(dapA)
SAME: SAMCFNEI73_Ch1603(dapA)
ATU: Atu4675(dapA)
ARA: Arad_9101(dapA)
ATF: Ach5_43980(dapA)
AVI: Avi_5576(dapA)
RLE: pRL100268
RLG: Rleg_6523
RIR: BN877_II1770(dapA6)
RHL: LPU83_0070(dapA1)
RHT: NT26_0737
SHZ: shn_20830
BME: BMEII1006
BMEL: DK63_2250(dapA)
BMEE: DK62_3157(dapA)
BMF: BAB2_0961
BABO: DK55_2905(dapA)
BABR: DO74_2220(dapA)
BABT: DK49_2334(dapA)
BABB: DK48_2892(dapA)
BABU: DK53_2908(dapA)
BABS: DK51_2394(dapA)
BABC: DO78_2149(dapA)
BMS: BRA0239
BSZ: DK67_2260(dapA)
BOV: BOV_A0218
BCS: BCAN_B0241(dapA)
BCAR: DK60_3114(dapA)
BCAS: DA85_11650
BMR: BMI_II235
BPP: BPI_II236
BPV: DK65_2237(dapA)
OAN: Oant_2898
OAH: DR92_3607(dapA)
BJA: bll4423
BRS: S23_37680
BOS: BSY19_3803(dapA)
XAU: Xaut_2517
SNO: Snov_0159
MET: M446_3517
MOR: MOC_2380
MAQU: Maq22A_1p30570(dapA)
PHL: KKY_176
MMED: Mame_00324(dapA_1)
SIL: SPOA0267
PDE: Pden_4867
KVU: EIO_3241
KVL: KVU_PB0057(dapA)
PSF: PSE_4635
PGD: Gal_02996
RMM: ROSMUCSMR3_03767(dapA)
SMAZ: LH19_25015
STAX: MC45_12600
SPHI: TS85_02905
SSAN: NX02_19040
SSY: SLG_18130
BLAS: BSY18_2026
RRU: Rru_A2066
RRF: F11_10625
TMO: TMO_b0087(dapA)
TXI: TH3_13295
BLIN: BLSMQ_1342
HAU: Haur_2503
DDR: Deide_1p00310(dapA)
RBA: RB1411 RB5277(dapA)
PSL: Psta_1258
PIR: VN12_09100(dapA_2)
PLM: Plim_2714
PLS: VT03_05360(dapAL)
PLH: VT85_05720(dapA_1)
FMR: Fuma_04091(dapA_1)
GES: VT84_21630(dapA_3) VT84_29725(dapA_5)
PBOR: BSF38_05465(yagE)
ACA: ACP_3272(dapA2)
GBA: J421_4881
RMR: Rmar_0494
CPI: Cpin_5586
FLN: FLA_4336
SMIZ: 4412673_01387(dapA_2)
MUC: MuYL_0983
MGOT: MgSA37_00735(dapAL)
DFE: Dfer_4271
SLI: Slin_1479
LBY: Lbys_1774
FAE: FAES_4418
GFL: GRFL_0582
FJG: BB050_03531(dapAL)
ZPR: ZPR_1385
MARM: YQ22_13920
DOK: MED134_07866(dapA3)
DDO: I597_0363(dapA_1)
ZGA: ZOBELLIA_4010(dapA1)
MLT: VC82_2606
EAO: BD94_2188
ELB: VO54_00505(dapA_1)
CHZ: CHSO_2633
TMAR: MARIT_0672(dapA1)
 » show all
Taxonomy
Reference
1  [PMID:5845838]
  Authors
Singh RM, Adams E.
  Title
Enzymatic deamination of delta-1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde).
  Journal
J. Biol. Chem. 240 (1965) 4344-51.
Reference
2  [PMID:5845839]
  Authors
Singh RM, Adams E.
  Title
Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline.
  Journal
J. Biol. Chem. 240 (1965) 4352-6.
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.22
IUBMB Enzyme Nomenclature: 3.5.4.22
ExPASy - ENZYME nomenclature database: 3.5.4.22
BRENDA, the Enzyme Database: 3.5.4.22
CAS: 9054-77-7

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