| Entry |
|
|---|
| Name |
methenyltetrahydromethanopterin cyclohydrolase;
5,10-methenyltetrahydromethanopterin cyclohydrolase;
N5,N10-methenyltetrahydromethanopterin cyclohydrolase;
methenyl-H4MPT cyclohydrolase |
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
 |
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| Sysname |
5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing) |
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| Reaction(IUBMB) |
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O =
5-formyl-5,6,7,8-tetrahydromethanopterin [RN:R03464] |
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| Reaction(KEGG) |
R03464
 |
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| Substrate |
5,10-methenyl-5,6,7,8-tetrahydromethanopterin [CPD:C04330];
H2O [CPD:C00001] |
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| Product |
5-formyl-5,6,7,8-tetrahydromethanopterin [CPD:C01274] |
|---|
| Comment |
Methanopterin is a pterin analogue. The enzyme is involved in the
formation of methane from CO2 in Methanobacterium
thermoautotrophicum. |
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| Pathway |
PATH: ec00680 Methane metabolism
PATH: ec00790 Folate biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01499 methenyltetrahydromethanopterin cyclohydrolase |
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| Genes |
MCA: MCA2863
BXE: Bxe_B2433(mch)
BPH: Bphy_5946 Bphy_6484
VAP: Vapar_3082
MPT: Mpe_A2609
LCH: Lcho_3150
MFA: Mfla_1658
MMB: Mmol_1344
MEI: Msip34_1502
XAU: Xaut_1788
MEX: Mext_1831
MEA: Mex_1p1763(mch)
MDI: METDI2515(mch)
MRD: Mrad2831_0530
MET: M446_5780
MPO: Mpop_1782
MCH: Mchl_2166
MNO: Mnod_6004
MSL: Msil_2387
GBE: GbCGDNIH1_0773
CBT: CLH_1638(mch)
HOR: Hore_19220
RBA: RB6759(mch)
MJA: MJ1636
MFE: Mefer_1327
MVU: Metvu_1361
MMP: MMP1191(mch)
MMQ: MmarC5_0399
MMX: MmarC6_1482
MMZ: MmarC7_0438
MAE: Maeo_0441
MVN: Mevan_0507
MAC: MA1710(mch)
MBA: Mbar_A2233
MMA: MM_2653
MBU: Mbur_0653
MTP: Mthe_0252
MHU: Mhun_0444 Mhun_2384
MLA: Mlab_0399
MEM: Memar_0263 Memar_0668
MBN: Mboo_0680
MPL: Mpal_2022
MPD: MCP_1132(mch-1) MCP_1888(mch-2)
MTH: MTH773
MST: Msp_1238(mch)
MSI: Msm_1723
MKA: MK0625(mch)
AFU: AF1935(mch)
HAL: VNG1686G(mch)
HSL: OE3383R(mch)
HMA: rrnAC1616(mch)
HWA: HQ2798A(mch)
NPH: NP2634A(mch)
HLA: Hlac_1693
HUT: Huta_1145
HMU: Hmuk_1816
RCI: LRC191(mch-1) RCIX2742(mch-2)
 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:4062290]
Donnelly MI, Escalante-Semerena JC, Rinehart KL Jr, Wolfe RS.
Methenyl-tetrahydromethanopterin cyclohydrolase in cell extracts of
Methanobacterium.
Arch. Biochem. Biophys. 242 (1985) 430-9.
Methanobacterium thermoautotrophicum [GN:mth] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.4.27
IUBMB Enzyme Nomenclature: 3.5.4.27
ExPASy - ENZYME nomenclature database: 3.5.4.27
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.4.27
BRENDA, the Enzyme Database: 3.5.4.27
CAS: 99533-50-3 |
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