KEGG   ENZYME: 3.5.4.29Help
Entry
EC 3.5.4.29                 Enzyme                                 

Name
GTP cyclohydrolase IIa
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
GTP 8,9-hydrolase (phosphate-forming)
Reaction(IUBMB)
GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate [RN:R07306]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
H2O [CPD:C00001]
Product
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C15563];
phosphate [CPD:C00009]
Comment
Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N7-methylguanosine 5'-triphosphate or inosine 5'-triphosphate. Xanthosine 5'-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC 3.5.4.25), this enzyme does not release formate, but does hydrolyse the diphosphate from GTP to phosphate.
History
EC 3.5.4.29 created 2003, modified 2011
Pathway
Riboflavin metabolism
Metabolic pathways
Orthology
K08096  
GTP cyclohydrolase IIa
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMP0405(gch3)
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MTH: 
MMG: 
MST: 
Msp_1404(gch3)
MSI: 
MRU: 
mru_1845(arfA)
MEB: 
Abm4_1486(arfA)
MEL: 
MEW: 
METH: 
MFV: 
HAL: 
HSL: 
OE2472F(gch31) OE2492F(gch32)
HMA: 
HHI: 
HHN: 
HWA: 
HQ2427A(gch3)
HWC: 
Hqrw_2717(gch3)
NPH: 
NP4142A(gch3)
NMO: 
Nmlp_2421(gch3)
HLA: 
HUT: 
HMU: 
HTU: 
NMG: 
HVO: 
HME: 
HJE: 
HBO: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
APE: 
ACJ: 
SMR: 
SHC: 
IHO: 
PFM: 
SSO: 
SOL: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
TUZ: 
TTN: 
VDI: 
VMO: 
ASC: 
CLG: 
NMR: 
NIR: 
NKR: 
CSY: 
NGA: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:12475257]
  Authors
Graham DE, Xu H, White RH.
  Title
A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates.
  Journal
Biochemistry. 41 (2002) 15074-84.
  Organism
Methanococcus jannaschii
  Sequence
[mja:MJ_0145]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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