KEGG ENZYME: 3.5.4.3

ENZYME: 3.5.4.3

Entry

EC 3.5.4.3 Enzyme

Name

guanine deaminase;
guanase;
guanine aminase;
GAH

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines

Sysname

guanine aminohydrolase

Reaction(IUBMB)

guanine + H2O = xanthine + NH3 [RN:R01676]

Reaction(KEGG)

R01676;
(other) R06137

Substrate

guanine [CPD:C00242];
H2O [CPD:C00001]

Product

xanthine [CPD:C00385];
NH3 [CPD:C00014]

Pathway

ec00230	Purine metabolism
ec01100	Metabolic pathways

Orthology

K01487

guanine deaminase

Genes

HSA:	9615(GDA)
PTR:	472950(GDA)
PPS:	100994542(GDA)
GGO:	101132455(GDA)
PON:	100174441(GDA)
MCC:	701796(GDA)
MMU:	14544(Gda)
RNO:	83585(Gda)
CFA:	484169(GDA)
AML:	100464046(GDA)
FCA:	101089902(GDA)
BTA:	525937(GDA)
SSC:	100621043
ECB:	100050096(GDA)
MDO:	100014959
SHR:	100931995
OAA:	100074075
GGA:	427253(GDA)
MGP:	100542196
TGU:	100217616(GDA)
ACS:	100562603(gda)
XLA:	398728(gda)
XTR:	100486841
DRE:	553701(gda)
TRU:	101071312
OLA:	101171588
BFO:	BRAFLDRAFT_116233
SPU:	100888431
DME:	Dmel_CG18143(DhpD)
DPO:	Dpse_GA14814
DAN:	Dana_GF17280
DER:	Dere_GG11774
DPE:	Dper_GL12339
DSE:	Dsec_GM10723
DSI:	Dsim_GD19697
DWI:	Dwil_GK11019
DYA:	Dyak_GE25370
DGR:	Dgri_GH18889
DMO:	Dmoj_GI24746
DVI:	Dvir_GJ14573
AGA:	AgaP_AGAP005282
AAG:	AaeL_AAEL003213
CQU:	CpipJ_CPIJ001079
AME:	727293
NVI:	100122760(NV12009)
TCA:	661687
PHU:	Phum_PHUM018350
NVE:	NEMVE_v1g244236
TAD:	TRIADDRAFT_53262
AQU:	100640526
PPP:	PHYPADRAFT_233220
CRE:	CHLREDRAFT_57990
VCN:	VOLCADRAFT_65103 VOLCADRAFT_82906
SCE:	YDL238C(GUD1)
KLA:	KLLA0D19492g
LTH:	KLTH0B08228g
PPA:	PAS_chr1-4_0524
VPO:	Kpol_1054p46
ZRO:	ZYRO0F15290g
CGR:	CAGL0C05555g
DHA:	DEHA2A05302g
PIC:	PICST_36448(GAH1)
PGU:	PGUG_00164
LEL:	LELG_05531
CAL:	CaO19.7029 CaO19_7029(CaJ7_0103)
CTP:	CTRG_04898
CDU:	CD36_70810
YLI:	YALI0E25740g
CLU:	CLUG_02167
NCR:	NCU07309 NCU09621
PAN:	PODANSg3687 PODANSg6904
MGR:	MGG_04119 MGG_13308
FGR:	FG02941.1 FG05323.1
SSL:	SS1G_01276 SS1G_13052
BFU:	BC1G_12091 BC1G_14331
ANI:	AN6815.2
NFI:	NFIA_029630 NFIA_047180 NFIA_055930
AFM:	AFUA_4G03770 AFUA_6G10210
AOR:	AOR_1_448144(AO090023000256) AOR_1_592054(AO090011000350)
AFV:	AFLA_041830 AFLA_106800
ACT:	ACLA_054670 ACLA_083940
PCS:	Pc14g00380 Pc16g11230 Pc20g15520
CIM:	CIMG_08451
CPW:	CPC735_061190
URE:	UREG_02523
PNO:	SNOG_08224
TML:	GSTUM_00010984001
SPO:	SPCC1672.03c
CNE:	CNN00990
LBC:	LACBIDRAFT_185911
CCI:	CC1G_01018
SCM:	SCHCODRAFT_81437
UMA:	UM02943.1
NGR:	NAEGRDRAFT_78946
DDI:	DDB_G0277743(guaD)
DPP:	DICPUDRAFT_76363
EHI:	EHI_151430(2.t00054)
EDI:	EDI_113080
TET:	TTHERM_00646860
TBR:	Tb927.5.4560(Tb05.26C7.180)
TCR:	504431.100 507951.150
LIF:	LINJ_29_0920
LBZ:	LBRM_29_0910
TVA:	TVAG_029040
PTI:	PHATRDRAFT_1769
PIF:	PITG_05263 PITG_07820
ECO:	b2883(guaD)
ECJ:	Y75_p2816(guaD)
ECD:	ECDH10B_3058(guaD)
EBW:	BWG_2609(guaD)
ECE:	Z4222(ygfP)
ECS:	ECs3756
ECF:	ECH74115_4173(guaD)
ETW:	ECSP_3853(guaD)
ELX:	CDCO157_3509
EOJ:	ECO26_3972(guaD)
EOI:	ECO111_3621(guaD)
EOH:	ECO103_3458(guaD)
ECG:	E2348C_3136(guaD)
EOK:	G2583_3537(guaD)
ELR:	ECO55CA74_16860
ECC:	c3461(ygfP)
ECP:	ECP_2877
ECI:	UTI89_C3268(ygfP)
ECV:	APECO1_3643(ygfP)
ECX:	EcHS_A3043(guaD)
ECW:	EcE24377A_3209(guaD)
ECM:	EcSMS35_3016(guaD)
ECY:	ECSE_3147
ECR:	ECIAI1_3003(guaD)
ECQ:	ECED1_3343(guaD)
ECK:	EC55989_3170(guaD)
ECT:	ECIAI39_3298(guaD)
EOC:	CE10_3322(guaD)
EUM:	ECUMN_3226(guaD)
ECZ:	ECS88_3162(guaD)
ELO:	EC042_3095(guaD)
ELN:	NRG857_14150
ELH:	ETEC_3077
ESO:	O3O_20595
ESM:	O3M_05095
ESL:	O3K_05050
ECL:	EcolC_0825
EBR:	ECB_02716(guaD)
EBD:	ECBD_0854
EKO:	EKO11_0848
EKF:	KO11_08350(guaD)
EAB:	ECABU_c31640(guaD)
EDH:	EcDH1_0809
EDJ:	ECDH1ME8569_2786(guaD)
EIH:	ECOK1_3269(guaD)
ENA:	ECNA114_2924(ygfP)
ELU:	UM146_02105
EUN:	UMNK88_3575(guaD)
ELW:	ECW_m3136(guaD)
ELL:	WFL_15315(guaD)
ELC:	i14_3180(ygfP)
ELD:	i02_3180(ygfP)
ELP:	P12B_c2981(guaD)
EBE:	B21_02678(guaD)
SSN:	SSON_3036
ETA:	ETA_17500(guaD)
EPY:	EpC_18410(guaD)
EPR:	EPYR_01983(ygfP)
EAM:	EAMY_1748(ygfP)
EAY:	EAM_1716(guaD)
EBI:	EbC_22740(guaD)
ERJ:	EJP617_28840(ygfP)
SGL:	SG1471
ENC:	ECL_02665
ENO:	ECENHK_08010
ESC:	Entcl_2797
EEC:	EcWSU1_01569(guaD)
ENL:	A3UG_07960
EAS:	Entas_1497
EAE:	EAE_19195
ESA:	ESA_pESA3p05529
CTU:	Ctu_1p00820(guaD)
KPN:	KPN_01791
KPU:	KP1_2840
KPM:	KPHS_27450
KPP:	A79E_2444
KPE:	KPK_2568(guaD)
KPO:	KPN2242_11830
KVA:	Kvar_2512
KOX:	KOX_16755
SPE:	Spro_2299
SRR:	SerAS9_2254
SRS:	SerAS12_2254
SRA:	SerAS13_2255
EIC:	NT01EI_3519
ETR:	ETAE_0853(guaD1) ETAE_3164(guaD2)
ETD:	ETAF_0797 ETAF_2855
DDC:	Dd586_1771
DDD:	Dda3937_04713
DZE:	Dd1591_1807
PAM:	PANA_1964(guaD)
PLF:	PANA5342_2214(guaD)
PAJ:	PAJ_1296(guaD)
PAQ:	PAGR_g2140
PVA:	Pvag_1372(guaD)
PAO:	Pat9b_1960
RAH:	Rahaq_2219
RAQ:	Rahaq2_2310
RAA:	Q7S_11225
VHA:	VIBHAR_01787
VEJ:	VEJY3_18256
VFU:	vfu_B00184
VFI:	VF_A0969(guaD)
VFM:	VFMJ11_A1091(guaD)
PPR:	PBPRA1930 PBPRA2246
PAE:	PA0134 PA1521
PAU:	PA14_01660(guaD) PA14_44770(gda1)
PAP:	PSPA7_0210(guaD2) PSPA7_3812(guaD1)
PAG:	PLES_01351 PLES_38071
PAF:	PAM18_0136 PAM18_3527
PNC:	NCGM2_0138(guaD) NCGM2_2407(gda1)
PDK:	PADK2_00685 PADK2_18115
PPU:	PP_4281(gad)
PPF:	Pput_1587
PPG:	PputGB1_3845
PPW:	PputW619_3607
PPT:	PPS_3685
PPB:	PPUBIRD1_1574
PPI:	YSA_08278
PPX:	T1E_2260(guaD)
PST:	PSPTO_3663(guaD)
PSB:	Psyr_1812
PSP:	PSPPH_1772(guaD)
PFL:	PFL_1886(guaD)
PFO:	Pfl01_1794
PFS:	PFLU4595
PFE:	PSF113_4033
PFC:	PflA506_3895(guaD)
PEN:	PSEEN1762(guaD)
PMY:	Pmen_2754
PMK:	MDS_1924
PSA:	PST_3084(guaD)
PSZ:	PSTAB_3131(guaD)
PSR:	PSTAA_3247(guaD)
PSC:	A458_05230
PSJ:	PSJM300_14280
PBA:	PSEBR_a1700
PFV:	Psefu_2626
CJA:	CJA_0551
AVN:	Avin_22260
PCR:	Pcryo_1143
ACI:	ACIAD3668(guaD)
ACD:	AOLE_19425
ACB:	A1S_2972 A1S_2973
ABM:	ABSDF2232(guaD) ABSDF3672(guaD)
ABY:	ABAYE2396(guaD) ABAYE3885(guaD)
ABC:	ACICU_00016
ABN:	AB57_0033(guaD)
ABB:	ABBFA_003520(guaD)
ABX:	ABK1_0025
ABZ:	ABZJ_00016
ABR:	ABTJ_03827
ABD:	ABTW07_0023(guaD)
ABH:	M3Q_233
ACC:	BDGL_002420(guaD)
SPL:	Spea_3243
SHL:	Shal_0659 Shal_3314
CPS:	CPS_4872(guaD)
PAT:	Patl_2429
AMC:	MADE_1007915
ALT:	ambt_10860
GAG:	Glaag_1938
TTU:	TERTU_2062(guaD)
FBL:	Fbal_1320
LPN:	lpg1985(gad)
LPF:	lpl1960
LPP:	lpp1966
LPC:	LPC_1468(gad)
LPA:	lpa_02897
FPH:	Fphi_1291
NOC:	Noc_1166
HCH:	HCH_01091
CSA:	Csal_1786
HEL:	HELO_2463(guaD)
MMW:	Mmwyl1_1677
MME:	Marme_2875
MPC:	Mar181_2135
AHA:	AHA_2175
AVR:	B565_1861
OCE:	GU3_15930
AFE:	Lferr_0915
AFR:	AFE_0772
CVI:	CV_0578
LHK:	LHK_00151
PSE:	NH8B_3855
RSO:	RSc2099(guaD)
RSC:	RCFBP_11290(guaD)
RSL:	RPSI07_1330(guaD)
RSN:	RSPO_c01334(guaD)
RPI:	Rpic_2250
RPF:	Rpic12D_1926
REU:	Reut_A2429
REH:	H16_A1013(guaD)
RME:	Rmet_0889(guaD)
CTI:	RALTA_A0997(guaD)
CNC:	CNE_1c09560(guaD)
BMA:	BMA0463(guaD)
BMV:	BMASAVP1_A2609(guaD)
BML:	BMA10229_A0981(guaD)
BMN:	BMA10247_0166(guaD)
BPS:	BPSL2541(guaD)
BPM:	BURPS1710b_3023(guaD)
BPL:	BURPS1106A_2978(guaD)
BPD:	BURPS668_2918(guaD)
BPR:	GBP346_A3117(guaD)
BPZ:	BP1026B_I0771(guaD)
BPQ:	BPC006_I3013
BTE:	BTH_I1610
BVI:	Bcep1808_0938
BUR:	Bcep18194_A4129 Bcep18194_B2814
BCN:	Bcen_0539
BCH:	Bcen2424_1018
BCM:	Bcenmc03_0977
BCJ:	BCAL2990(guaD)
BAM:	Bamb_0881
BAC:	BamMC406_0893
BMU:	Bmul_2377
BMJ:	BMULJ_00864(guaD)
BCT:	GEM_2502
BXE:	Bxe_A0946
BPH:	Bphy_0709
BPY:	Bphyt_3045
BGL:	bglu_1g08460
BUG:	BC1001_2673
BGE:	BC1002_2263
BGF:	BC1003_2642
BRH:	RBRH_00081
BGD:	bgla_1g09290
BYI:	BYI23_A006850
BUK:	MYA_0907
BPX:	BUPH_03246
PUT:	PT7_3002
RFR:	Rfer_3295
POL:	Bpro_1496
PNA:	Pnap_1047
AJS:	Ajs_1129
DIA:	Dtpsy_1049
AAA:	Acav_1153
VEI:	Veis_1336
DAC:	Daci_2147 Daci_2513
DEL:	DelCs14_4147 DelCs14_4540
VAP:	Vapar_3881
VPE:	Varpa_4485
CTT:	CtCNB1_3672
ADN:	Alide_1067
ADK:	Alide2_4031
RTA:	Rta_32210(guaD)
MPT:	Mpe_A0801
HAR:	HEAR0883 HEAR1176
MMS:	mma_0504(guaD)
HSE:	Hsero_3265(guaD)
CFU:	CFU_4147(guaD)
LCH:	Lcho_3458
TIN:	Tint_1631
EBA:	ebA4668(guaD)
AZO:	azo2223(guaD)
TMZ:	Tmz1t_1336
TDN:	Suden_1831
DMA:	DMR_15390(guaD)
BMX:	BMS_1461(guaD)
DAT:	HRM2_28460(guaD)
SCL:	sce1093(ygfP)
HOH:	Hoch_5972
MLO:	mlr5142
MCI:	Mesci_0363
MOP:	Mesop_0346
MES:	Meso_2838
SME:	SM_b20849(guaD2) SM_b21293(guaD1)
SMK:	Sinme_4576 Sinme_4908
SMQ:	SinmeB_3532 SinmeB_3867
SMX:	SM11_pD0457(guaD2) SM11_pD0797(guaD1)
SMI:	BN406_05530(guaD1) BN406_05860(guaD3)
SMD:	Smed_4494 Smed_4625
RHI:	NGR_b12730 NGR_c23930(guaD)
SFH:	SFHH103_02260(guaD) SFHH103_05779(guaD)
SFD:	USDA257_c09860(guaD1) USDA257_c47520(guaD2)
ATU:	Atu2315(gda)
ARA:	Arad_3320(guaD) Arad_8948(guaD)
AVI:	Avi_3326(guaD) Avi_5414
AGR:	AGROH133_07997(gda)
RET:	RHE_CH03130(guaD)
REC:	RHECIAT_CH0003291(guaD)
RLE:	RL3577(guaD)
RLT:	Rleg2_2870
RLG:	Rleg_3142
BME:	BMEI1571
BMI:	BMEA_A0391(guaD)
BMZ:	BM28_A0385(guaD)
BMG:	BM590_A0381
BMW:	BMNI_I0376
BMF:	BAB1_0383
BMB:	BruAb1_0380
BMC:	BAbS19_I03540
BAA:	BAA13334_I03352
BMS:	BR0354
BSI:	BS1330_I0355
BMT:	BSUIS_A0385(guaD)
BSV:	BSVBI22_A0355
BOV:	BOV_0370(guaD)
BCS:	BCAN_A0362(guaD)
BSK:	BCA52141_I1117
BMR:	BMI_I359(guaD)
BPP:	BPI_I388(guaD)
OAN:	Oant_0456
BJA:	blr3880
AZC:	AZC_4625
SNO:	Snov_3385
MEX:	Mext_1727
MEA:	Mex_1p1653(guaD)
MDI:	METDI2401(guaD)
MCH:	Mchl_2046
MET:	M446_2623
MPO:	Mpop_1087
MNO:	Mnod_4655
PHL:	KKY_2233
CCR:	CC_2616
CCS:	CCNA_02699
CAK:	Caul_3717
CSE:	Cseg_1079
AEX:	Astex_2535
SIL:	SPO2956
SIT:	TM1040_1905 TM1040_3479
RSP:	RSP_1896
RSH:	Rsph17029_0545
RSQ:	Rsph17025_0293
RSK:	RSKD131_0205
RCP:	RCAP_rcc00876(guaD)
JAN:	Jann_2724
RDE:	RD1_2008(guaD)
PDE:	Pden_4260
DSH:	Dshi_2771(guaD)
KVU:	EIO_2240 EIO_2868(guaD)
PSF:	PSE_0820(guaD)
ZMO:	ZMO0939
ZMN:	Za10_0359
GOX:	GOX0898
ACR:	Acry_1148
AMV:	ACMV_07480(guaD)
GDI:	GDI_3167(guaD)
GDJ:	Gdia_3192
GXY:	GLX_08050
APT:	APA01_12970
APW:	APA42C_12970
APF:	APA03_12970
APU:	APA07_12970
APG:	APA12_12970
APQ:	APA22_12970
APX:	APA26_12970
APZ:	APA32_12970
RRU:	Rru_A0650
AZL:	AZL_d02660(guaD)
ALI:	AZOLI_p40369(guaD)
PBR:	PB2503_11574
BSU:	BSU13170(guaD)
BLI:	BL03735(guaD)
BLD:	BLi01418(guaD)
BCL:	ABC3819(gde)
BPU:	BPUM_1214(guaD)
LSP:	Bsph_1757
BBE:	BBR47_05470(guaD)
GYM:	GYMC10_1074
LBR:	LVIS_1043
LCA:	LSEI_1136
LFE:	LAF_1014
EFA:	EF2431
OOE:	OEOE_1303
AUR:	HMPREF9243_0091(guaD)
CAC:	CA_C0282
CAE:	SMB_G0288
CTH:	Cthe_2515
CBE:	Cbei_1972
CLJ:	CLJU_c23960
CSH:	Closa_1021
CCB:	Clocel_0475
CDF:	CD630_16630(guaD)
CDC:	CD196_1585(guaD)
CDL:	CDR20291_1560(guaD)
PTH:	PTH_2319(SsnA) PTH_2359(SsnA)
OVA:	OBV_45420
VPR:	Vpar_0512
MED:	MELS_0573
MSM:	MSMEG_1298
MVA:	Mvan_0863 Mvan_5279
MAB:	MAB_2928
ASD:	AS9A_4197
RHA:	RHA1_ro03824
RER:	RER_42040(guaD)
ROP:	ROP_36860(guaD)
GBR:	Gbro_4377
TPR:	Tpau_2966
SRT:	Srot_2982
CMI:	CMM_1917
CMS:	CMS_1312
AAU:	AAur_1563(guaD) AAur_3398
KRH:	KRH_21400(guaD)
BCV:	Bcav_1670
ICA:	Intca_1481
NCA:	Noca_1141
NML:	Namu_0256 Namu_0506
KRA:	Krad_2072
SEN:	SACE_1260(guaD) SACE_6093(gde)
STP:	Strop_0081
SNG:	SNE_A10140(gDA)
SUS:	Acid_0357 Acid_2535
PDI:	BDI_1128
CHU:	CHU_2684(guaD)
STR:	Sterm_0591
IPA:	Isop_3633
EMI:	Emin_0107
AVA:	Ava_1577 Ava_2029
DRA:	DR_A0180
DGE:	Dgeo_2606
TRA:	Trad_2850
MRB:	Mrub_1462
MSV:	Mesil_1795
OPR:	Ocepr_0908
MAC:	MA3407
HWA:	HQ2049A(guaD) HQ2620A(guaD)
NPH:	NP4788A(guaD_3)
ABI:	Aboo_1468

» show all

Reference

1 [PMID:16578130]

Authors

Hitchings GH, Falco EA.

Title

The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase.

Journal

Proc. Natl. Acad. Sci. U. S. A. 30 (1944) 294-7.

Organism

Girella nigricans

Reference

Authors

Kalckar, H.M.

Title

Differential spectrophotometry of purine compounds by means of specific enzymes. III. Studies of the enzymes of purine metabolism.

Journal

J. Biol. Chem. 167 (1947) 461-475.

Reference

3 [PMID:13278325]

Authors

RABINOWITZ JC, BARKER HA.

Title

Purine fermentation by Clostridium cylindrosporum. II. Purine transformations.

Journal

J. Biol. Chem. 218 (1956) 161-73.

Organism

Clostridium cylindrosporum

Other DBs

ExplorEnz - The Enzyme Database:

3.5.4.3

IUBMB Enzyme Nomenclature:

3.5.4.3

ExPASy - ENZYME nomenclature database:

3.5.4.3

BRENDA, the Enzyme Database:

3.5.4.3

CAS:

9033-16-3

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (6)   
   KEGG REACTION (2)   
   KEGG RPAIR (3)   
   KEGG RCLASS (1)   
Gene (6806)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (583)   
   KEGG DGENES (16)   
   KEGG EGENES (51)   
   KEGG MGENES (6155)   
Protein sequence (2183)   
   UniProt (1071)   
   PRF (61)   
   RefSeq(pep) (1038)   
   PDBSTR (11)   
   PMD (2)   
DNA sequence (1823)   
   RefSeq(nuc) (1055)   
   GenBank (379)   
   EMBL (389)   
3D Structure (7)   
   PDB (7)   
Protein domain (1)   
   InterPro (1)   
Literature (2)   
   PubMed (2)   
Enzyme (4)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
All databases (10845)   

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