KEGG   ENZYME: 3.5.4.30Help
Entry
EC 3.5.4.30                 Enzyme                                 

Name
dCTP deaminase (dUMP-forming)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
dCTP aminohydrolase (dUMP-forming)
Reaction(IUBMB)
dCTP + 2 H2O = dUMP + diphosphate + NH3 [RN:R07307]
Reaction(KEGG)
Substrate
dCTP [CPD:C00458];
H2O [CPD:C00001]
Product
dUMP [CPD:C00365];
diphosphate [CPD:C00013];
NH3 [CPD:C00014]
Comment
Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13, dCTP deaminase and EC 3.6.1.23, dUTP diphosphatase), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly.
History
EC 3.5.4.30 created 2003
Pathway
ec00240  Pyrimidine metabolism
Orthology
K09887  dCTP deaminase (dUMP-forming)
Genes
MJA: MJ_0430
MFE: Mefer_1292
MVU: Metvu_0792
MFS: MFS40622_1697
MIF: Metin_0912
MJH: JH146_1343
MIG: Metig_1531
MMP: MMP1426(dcd)
MMQ: MmarC5_0152
MMX: MmarC6_1247
MMD: GYY_07965
MAE: Maeo_1411
MVO: Mvol_1036
 » show all
Taxonomy
Reference
1  [PMID:12538648]
  Authors
Li H, Xu H, Graham DE, White RH.
  Title
The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase.
  Journal
J. Biol. Chem. 278 (2003) 11100-6.
  Sequence
[mja:MJ_0430]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.30
IUBMB Enzyme Nomenclature: 3.5.4.30
ExPASy - ENZYME nomenclature database: 3.5.4.30
BRENDA, the Enzyme Database: 3.5.4.30

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