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Entry
EC 3.5.4.32                 Enzyme                                 

Name
8-oxoguanine deaminase;
8-OGD
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
8-oxoguanine aminohydrolase
Reaction(IUBMB)
8-oxoguanine + H2O = urate + NH3 [RN:R09876]
Reaction(KEGG)
Substrate
8-oxoguanine [CPD:C20155];
H2O [CPD:C00001]
Product
urate [CPD:C00366];
NH3 [CPD:C00014]
Comment
Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.
History
EC 3.5.4.32 created 2012
Orthology
K18456  
8-oxoguanine deaminase
Genes
EBI: 
PAO: 
RAH: 
RAA: 
VEJ: 
VFU: 
PPR: 
PAE: 
PAEV: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
PPUU: 
PST: 
PSB: 
PSYR: 
PSP: 
PCI: 
PFL: 
PPRC: 
PFO: 
PFS: 
PFE: 
PFC: 
PPZ: 
PEN: 
PMY: 
PMK: 
PSA: 
PST_3078(atzB)
PSZ: 
PSR: 
PSC: 
PSJ: 
PSH: 
PBA: 
PDR: 
PSV: 
PSK: 
CJA: 
PCR: 
PSO: 
ACI: 
PAT: 
ALT: 
GAG: 
GPS: 
TTU: 
HCH: 
HEL: 
TOL: 
TOR: 
OCE: 
BUO: 
RHL: 
BJA: 
BJU: 
BRA: 
BBT: 
BRS: 
AOL: 
MEX: 
MEA: 
MDI: 
MCH: 
MRD: 
MET: 
MPO: 
MNO: 
PGV: 
ART: 
AAU: 
ACH: 
APN: 
ARR: 
 » show all
Taxonomy
Reference
1  [PMID:20088583]
  Authors
Hall RS, Fedorov AA, Marti-Arbona R, Fedorov EV, Kolb P, Sauder JM, Burley SK, Shoichet BK, Almo SC, Raushel FM
  Title
The hunt for 8-oxoguanine deaminase.
  Journal
J. Am. Chem. Soc. 132 (2010) 1762-3.
  Organism
Pseudomonas aeruginosa
  Sequence
[pae:PA0142]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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