KEGG   ENZYME: 3.5.4.32Help
Entry
EC 3.5.4.32                 Enzyme                                 
Name
8-oxoguanine deaminase;
8-OGD
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
8-oxoguanine aminohydrolase
Reaction(IUBMB)
8-oxoguanine + H2O = urate + NH3 [RN:R09876]
Reaction(KEGG)
Substrate
8-oxoguanine [CPD:C20155];
H2O [CPD:C00001]
Product
urate [CPD:C00366];
NH3 [CPD:C00014]
Comment
Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.
Reference
1  [PMID:20088583]
  Authors
Hall RS, Fedorov AA, Marti-Arbona R, Fedorov EV, Kolb P, Sauder JM, Burley SK, Shoichet BK, Almo SC, Raushel FM
  Title
The hunt for 8-oxoguanine deaminase.
  Journal
J. Am. Chem. Soc. 132 (2010) 1762-3.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system