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Entry
EC 3.5.4.32                 Enzyme                                 

Name
8-oxoguanine deaminase;
8-OGD
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
8-oxoguanine aminohydrolase
Reaction(IUBMB)
8-oxoguanine + H2O = urate + NH3 [RN:R09876]
Reaction(KEGG)
Substrate
8-oxoguanine [CPD:C20155];
H2O [CPD:C00001]
Product
urate [CPD:C00366];
NH3 [CPD:C00014]
Comment
Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.
History
EC 3.5.4.32 created 2012
Orthology
K18456  8-oxoguanine deaminase
Genes
RAH: Rahaq_0416
RAA: Q7S_02075
EBI: EbC_00100
PAO: Pat9b_5500
TCI: A7K98_17620
VNA: PN96_11505
VEJ: VEJY3_01780
VFU: vfu_B01418
VCY: IX92_16460
VCT: JV59_22650
PPR: PBPRA2267(SCO6213)
PAE: PA0142
PAEV: N297_148
PAEI: N296_148
PAEP: PA1S_00750
PAEM: U769_00735
PAEL: T223_00725
PAEG: AI22_03175
PAEC: M802_148
PAEO: M801_148
PMY: Pmen_3705
PMK: MDS_4016
PPSE: BN5_0831(atzB)
PST: PSPTO_0765(atzB)
PSB: Psyr_0669
PSYR: N018_03750
PFL: PFL_0724
PPRO: PPC_0739
PFS: PFLU_0669
PFB: VO64_3744
PMAN: OU5_2776
PEN: PSEEN0675
PSA: PST_3078(atzB)
PSZ: PSTAB_3125(atzB)
PSR: PSTAA_3241(atzB)
PSTT: CH92_16050
PSEM: TO66_03465
PSOS: POS17_0716
PANR: A7J50_0652
PSIL: PMA3_25940
ACI: ACIAD0761
SPSW: Sps_03950
PAT: Patl_2224
AAUS: EP12_05760
GPS: C427_3020
CJA: CJA_0540
HCH: HCH_01106
HEL: HELO_1075
HBE: BEI_0049
TOL: TOL_3302
OAI: OLEAN_C32740(atzB)
OCE: GU3_03980
BJA: bll6159
BRA: BRADO1738
BBT: BBta_2050
BRS: S23_21350
AOL: S58_58060
BRAD: BF49_5470
BOS: BSY19_863
MDI: METDI2371(atzB) METDI3796
MET: M446_2144
MPO: Mpop_1121
MNO: Mnod_1111
MOR: MOC_4773
HDI: HDIA_3953
ART: Arth_3425
AAU: AAur_3399
ACH: Achl_3205
BLIN: BLSMQ_0075
 » show all
Taxonomy
Reference
1  [PMID:20088583]
  Authors
Hall RS, Fedorov AA, Marti-Arbona R, Fedorov EV, Kolb P, Sauder JM, Burley SK, Shoichet BK, Almo SC, Raushel FM
  Title
The hunt for 8-oxoguanine deaminase.
  Journal
J. Am. Chem. Soc. 132 (2010) 1762-3.
  Sequence
[pae:PA0142]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.32
IUBMB Enzyme Nomenclature: 3.5.4.32
ExPASy - ENZYME nomenclature database: 3.5.4.32
BRENDA, the Enzyme Database: 3.5.4.32

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