KEGG   ENZYME: 3.5.4.35Help
Entry
EC 3.5.4.35                 Enzyme                                 

Name
tRNA(cytosine8) deaminase;
CDAT8
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
tRNA(cytosine8) aminohydrolase
Reaction(IUBMB)
cytosine8 in tRNA + H2O = uracil8 in tRNA + NH3 [RN:R10232]
Reaction(KEGG)
Substrate
cytosine8 in tRNA;
H2O [CPD:C00001]
Product
uracil8 in tRNA;
NH3 [CPD:C00014]
Comment
The enzyme from Methanopyrus kandleri specifically catalyses the deamimation of cytosine at poition 8 of tRNA in 30 different tRNAs. This cytosine-to-uracil editing guarantees the proper folding and functionality of the tRNAs.
History
EC 3.5.4.35 created 2013
Orthology
K16930  
tRNA(cytosine8) deaminase
Genes
MKA: 
Taxonomy
Reference
1  [PMID:19407206]
  Authors
Randau L, Stanley BJ, Kohlway A, Mechta S, Xiong Y, Soll D
  Title
A cytidine deaminase edits C to U in transfer RNAs in Archaea.
  Journal
Science. 324 (2009) 657-9.
  Sequence
[mka:MK0935]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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