KEGG   ENZYME: 3.5.4.36Help
Entry
EC 3.5.4.36                 Enzyme                                 

Name
mRNA(cytosine6666) deaminase;
APOBEC-1 (catalytic component of an RNA-editing complex);
APOBEC1 (catalytic subunit);
apolipoprotein B mRNA-editing enzyme 1 (catalytic component of an RNA-editing complex);
apoB mRNA-editing enzyme catalytic polypeptide 1 (catalytic component of an RNA-editing complex);
apoB mRNA editing complex;
apolipoprotein B mRNA editing enzyme;
REPR
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
mRNA(cytosine6666) aminohydrolase
Reaction(IUBMB)
cytosine6666 in apolipoprotein B mRNA + H2O = uracil6666 in apolipoprotein B mRNA + NH3
Substrate
cytosine6666 in apolipoprotein B mRNA;
H2O [CPD:C00001]
Product
uracil6666 in apolipoprotein B mRNA;
NH3 [CPD:C00014]
Comment
The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site [3].
History
EC 3.5.4.36 created 2013
Orthology
K16932  
C->U-editing enzyme APOBEC1
Genes
HSA: 
339(APOBEC1)
PTR: 
748253(APOBEC1)
PPS: 
100987748(APOBEC1)
GGO: 
109029027(APOBEC1)
PON: 
100461036(APOBEC1)
NLE: 
100605699(APOBEC1)
MCC: 
715554(APOBEC1)
MCF: 
102146028(APOBEC1)
CSAB: 
103218863(APOBEC1)
RRO: 
104681677(APOBEC1)
RBB: 
108542064(APOBEC1)
CJC: 
100394516(APOBEC1)
SBQ: 
101039475(APOBEC1)
MMU: 
11810(Apobec1)
RNO: 
25383(Apobec1)
CGE: 
100760326(Apobec1)
NGI: 
103727568(Apobec1)
HGL: 
101708425(Apobec1)
CCAN: 
109680707(Apobec1)
OCU: 
100009191(APOBEC1)
TUP: 
102476841(APOBEC1)
CFA: 
486699(APOBEC1)
AML: 
100473834(APOBEC1)
UMR: 
103669184(APOBEC1)
FCA: 
101100896(APOBEC1)
PTG: 
102951006(APOBEC1)
AJU: 
106965478(APOBEC1)
BTA: 
516043(APOBEC1)
BOM: 
102271536(APOBEC1)
BIU: 
109558589(APOBEC1)
PHD: 
102322846(APOBEC1)
CHX: 
102181846(APOBEC1)
OAS: 
101105238(APOBEC1)
SSC: 
100512412(APOBEC1)
CFR: 
102517248(APOBEC1)
CDK: 
105098173(APOBEC1)
BACU: 
103021051(APOBEC1)
LVE: 
103079923(APOBEC1)
ECB: 
100061100(APOBEC1)
EPZ: 
103556649(APOBEC1)
EAI: 
106837455(APOBEC1)
MYB: 
102246260(APOBEC1)
MYD: 
102753131(APOBEC1)
HAI: 
109372734(APOBEC1)
RSS: 
109435525(APOBEC1)
PALE: 
102879919(APOBEC1)
LAV: 
100656399(APOBEC1)
MDO: 
554187(APOBEC1)
SHR: 
100932638(APOBEC1)
OAA: 
100085961(APOBEC1)
APLA: 
101792029(APOBEC1)
ACYG: 
106048066(APOBEC1)
TGU: 
101233449(APOBEC1)
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
101914977(APOBEC1)
FCH: 
102048970(APOBEC1)
CLV: 
102087964(APOBEC1)
ASN: 
AMJ: 
102571342(APOBEC1) 102571574(APOBEC1A) 109281895
PSS: 
CMY: 
CPIC: 
ACS: 
PBI: 
 » show all
Taxonomy
Reference
1  [PMID:15273326]
  Authors
Chester A, Weinreb V, Carter CW Jr, Navaratnam N
  Title
Optimization of apolipoprotein B mRNA editing by APOBEC1 apoenzyme and the role of its auxiliary factor, ACF.
  Journal
RNA. 10 (2004) 1399-411.
Reference
2  [PMID:10373583]
  Authors
Fujino T, Navaratnam N, Jarmuz A, von Haeseler A, Scott J
  Title
C-->U editing of apolipoprotein B mRNA in marsupials: identification and characterisation of APOBEC-1 from the American opossum Monodelphus domestica.
  Journal
Nucleic. Acids. Res. 27 (1999) 2662-71.
  Sequence
[mdo:554187]
Reference
3  [PMID:8280158]
  Authors
Barnes C, Smith HC
  Title
Apolipoprotein B mRNA editing in vitro is a zinc-dependent process.
  Journal
Biochem. Biophys. Res. Commun. 197 (1993) 1410-4.
Reference
4  [PMID:12881431]
  Authors
Chester A, Somasekaram A, Tzimina M, Jarmuz A, Gisbourne J, O'Keefe R, Scott J, Navaratnam N
  Title
The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.
  Journal
EMBO. J. 22 (2003) 3971-82.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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