KEGG   ENZYME: 3.5.4.37Help
Entry
EC 3.5.4.37                 Enzyme                                 

Name
double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
double-stranded RNA adenine aminohydrolase
Reaction(IUBMB)
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3
Substrate
adenine in double-stranded RNA;
H2O [CPD:C00001]
Product
hypoxanthine in double-stranded RNA;
NH3 [CPD:C00014]
Comment
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].
History
EC 3.5.4.37 created 2013
Orthology
K12968  
double-stranded RNA-specific adenosine deaminase
Genes
HSA: 
103(ADAR)
PTR: 
457349(ADAR)
PPS: 
100988581(ADAR)
GGO: 
101134621(ADAR)
PON: 
100457633(ADAR)
NLE: 
100607902(ADAR)
MCC: 
718759(ADAR)
MCF: 
101926284(ADAR)
CSAB: 
103223917(ADAR)
RRO: 
104663489(ADAR)
RBB: 
CJC: 
100386367(ADAR)
SBQ: 
101031414(ADAR)
MMU: 
56417(Adar)
RNO: 
81635(Adar)
CGE: 
100760578(Adar)
NGI: 
103751329(Adar)
HGL: 
101722209(Adar)
CCAN: 
109688036(Adar)
OCU: 
100346984(ADAR)
TUP: 
102485185(ADAR)
CFA: 
100855668(ADAR)
AML: 
100470274(ADAR)
UMR: 
103668714(ADAR)
FCA: 
101084681(ADAR)
PTG: 
102950196(ADAR)
AJU: 
106988378(ADAR)
BTA: 
505134(ADAR)
BOM: 
102267031(ADAR)
BIU: 
109554054(ADAR)
PHD: 
102343559(ADAR)
CHX: 
102172585(ADAR)
OAS: 
101104366(ADAR)
SSC: 
100523784(ADAR)
CFR: 
102512737(ADAR)
CDK: 
105089080(ADAR)
BACU: 
103018582(ADAR)
LVE: 
103077270(ADAR)
ECB: 
100056984(ADAR)
EPZ: 
103555415(ADAR)
EAI: 
106828524(ADAR)
MYB: 
102242753(ADAR)
MYD: 
102754391(ADAR)
HAI: 
109393401(ADAR)
RSS: 
109434689(ADAR)
PALE: 
102895875(ADAR)
LAV: 
100665054(ADAR)
MDO: 
100020840(ADAR)
SHR: 
100925968(ADAR)
GGA: 
769675(ADAR)
MGP: 
100541796(ADAR)
CJO: 
107324489(ADAR)
APLA: 
101796198(ADAR)
ACYG: 
106048529(ADAR)
TGU: 
100220215(ADAR)
GFR: 
102033970(ADAR)
FAB: 
101806137(ADAR)
PHI: 
102105960(ADAR)
PMAJ: 
107214561(ADAR)
CCW: 
104698661(ADAR)
FPG: 
101910869(ADAR)
FCH: 
102049629(ADAR)
CLV: 
102086506(ADAR)
AAM: 
106483717(ADAR)
ASN: 
102377665(ADAR)
AMJ: 
102575445(ADAR)
PSS: 
102449470(ADAR)
CMY: 
102941128(ADAR)
CPIC: 
101936755(ADAR)
ACS: 
PVT: 
110081003(ADAR)
PBI: 
103050667(ADAR)
GJA: 
107117082(ADAR)
XLA: 
394279(adar-a) 397992(adar.S)
XTR: 
100493195(adar)
NPR: 
108798342(ADAR)
DRE: 
58119(adar)
SRX: 
SANH: 
SGH: 
IPU: 
108265537(adar)
AMEX: 
103023414(adar)
TRU: 
101073967(adar)
TNG: 
LCO: 
104922500(adar)
NCC: 
104958853(adar)
MZE: 
101475397(adar)
OLA: 
101155879(adar)
XMA: 
102217978(adar)
CSEM: 
LCF: 
108885934(adar)
HCQ: 
109521078(adar)
BPEC: 
SASA: 
ELS: 
105024448(adar)
SFM: 
108925759(adar)
LCM: 
102360746(ADAR)
BFO: 
CIN: 
SPU: 
APLC: 
SKO: 
ISC: 
CEL: 
CBR: 
CBG24155(Cbr-adr-2)
NAI: 
LGI: 
CRG: 
OBI: 
LAK: 
NVE: 
ADF: 
AQU: 
MIS: 
MPP: 
SMIN: 
v1.2.029917.t2(symbB.v1.2.029917.t2)
AAF: 
 » show all
Taxonomy
Reference
1  [PMID:8144588]
  Authors
Hough RF, Bass BL
  Title
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.
  Journal
J. Biol. Chem. 269 (1994) 9933-9.
Reference
2  [PMID:9614652]
  Authors
O'Connell MA, Gerber A, Keegan LP
  Title
Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.
  Journal
Methods. 15 (1998) 51-62.
Reference
3  [PMID:11421361]
  Authors
Wong SK, Sato S, Lazinski DW
  Title
Substrate recognition by ADAR1 and ADAR2.
  Journal
RNA. 7 (2001) 846-58.
Reference
4  [PMID:16141067]
  Authors
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL
  Title
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
  Journal
Science. 309 (2005) 1534-9.
  Sequence
[hsa:104]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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