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Entry
EC 3.5.4.39                 Enzyme                                 

Name
GTP cyclohydrolase IV;
MptA;
GTP cyclohydrolase MptA
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
GTP 7,8-8,9-dihydrolase (cyclizing, formate-releasing, diphosphate-releasing)
Reaction(IUBMB)
GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate [RN:R10348]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
H2O [CPD:C00001]
Product
7,8-dihydroneopterin 2',3'-cyclic phosphate [CPD:C20567];
formate [CPD:C00058];
diphosphate [CPD:C00013]
Comment
Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29).
History
EC 3.5.4.39 created 2013
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K17488  GTP cyclohydrolase IV
Genes
ARX: ARZXY2_4868
TFL: RPIT_09110
AMO: Anamo_1142
MJA: MJ_0775
MFE: Mefer_1030
MVU: Metvu_0037
MFS: MFS40622_1401
MIF: Metin_0324
MJH: JH146_1120
MIG: Metig_1140
MMP: MMP0034
MMD: GYY_00175
MAE: Maeo_1148
MVO: Mvol_1397
MAC: MA_4517
MBAR: MSBR2_3338
MBAK: MSBR3_3388
MMA: MM_1222
MMAC: MSMAC_0096
METM: MSMTP_0123
MTHE: MSTHC_1631
MTHR: MSTHT_1658
MHOR: MSHOH_0106
MBU: Mbur_0054
MMET: MCMEM_0637
MMH: Mmah_1229
MPY: Mpsy_1383
MTP: Mthe_0355
MCJ: MCON_3313
MHI: Mhar_1861
MHU: Mhun_2334
MLA: Mlab_0018
MEMA: MMAB1_1760(mptA)
MPI: Mpet_0589
MBN: Mboo_0480
MPL: Mpal_0083
MPD: MCP_1133(mptA-1) MCP_2574(mptA-2)
MEZ: Mtc_0027(mptA-1) Mtc_1062(mptA-2)
MTH: MTH_1196
METC: MTCT_1089
MWO: MWSIV6_1589(mptA)
METE: tca_01153(folE2)
MST: Msp_0294
MSI: Msm_1033
MRU: mru_1962(mptA)
MEB: Abm4_1545(mptA)
MMIL: sm9_2045(mptA)
MEYE: TL18_09410
MOL: YLM1_1409
METH: MBMB1_1719(mptA)
MFC: BRM9_0972(mptA)
MFI: DSM1535_0942(mptA)
MCUB: MCBB_2018(mptA)
MFV: Mfer_0397
MKA: MK0485
AFU: AF_1179
FPL: Ferp_0754
GAC: GACE_2009
GAH: GAH_01203
HAL: VNG_1901C
HSL: OE_3673F(mptA)
HHB: Hhub_3237(mptA)
HALH: HTSR_1822
HHSR: HSR6_1891(mptA)
HMA: rrnAC3309
HHI: HAH_0546(mptA)
NPH: NP_2514A(mptA)
NMO: Nmlp_1862(mptA)
HUT: Huta_2260
HTI: HTIA_1987(mptA)
HMU: Hmuk_1583
HWA: HQ_3317A(mptA)
HWC: Hqrw_3846(mptA)
HVO: HVO_2348
HME: HFX_2357
HLA: Hlac_2276
HTU: Htur_0488
NMG: Nmag_2853
NAT: NJ7G_0097
SALI: L593_14035
TAC: Ta1138
TVO: TVG1279013(TVG1279013)
PTO: PTO1009
CDIV: CPM_1080
MEAR: Mpt1_c09750(mptA)
MARC: AR505_0210
PHO: PH1783(PH1783)
PAB: PAB0223
PFU: PF1832
PFI: PFC_09430
PYN: PNA2_0389
PYS: Py04_1714
TKO: TK0793
TON: TON_0757
TGA: TGAM_1430
TSI: TSIB_1100
THE: GQS_01100
THA: TAM4_1572
THM: CL1_1922
TLT: OCC_00185
THS: TES1_0675
TNU: BD01_0945
TEU: TEU_10520
PPAC: PAP_06000
ABI: Aboo_0781
APE: APE_2308
ACJ: ACAM_1445
DKA: DKAM_0427
TAG: Tagg_0592
IAG: Igag_0283
ASC: ASAC_0336
KCR: Kcr_0832
LOKI: Lokiarch_29360(mptA)
 » show all
Taxonomy
Reference
1  [PMID:17497938]
  Authors
Grochowski LL, Xu H, Leung K, White RH
  Title
Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii.
  Journal
Biochemistry. 46 (2007) 6658-67.
  Sequence
[mja:MJ_0775]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.39
IUBMB Enzyme Nomenclature: 3.5.4.39
ExPASy - ENZYME nomenclature database: 3.5.4.39
BRENDA, the Enzyme Database: 3.5.4.39

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