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Entry
EC 3.5.4.40                 Enzyme                                 

Name
aminodeoxyfutalosine deaminase;
AFL deaminase;
aminofutalosine deaminase;
mqnX (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
6-amino-6-deoxyfutalosine deaminase
Reaction(IUBMB)
6-amino-6-deoxyfutalosine + H2O = futalosine + NH3 [RN:R10695]
Reaction(KEGG)
Substrate
6-amino-6-deoxyfutalosine [CPD:C20773];
H2O [CPD:C00001]
Product
futalosine [CPD:C16999];
NH3 [CPD:C00014]
Comment
The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 3.5.4.40 created 2014
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K18286  
aminodeoxyfutalosine deaminase
Genes
NBR: 
NNO: 
SCO: 
SCO5662(SC6A9.05)
SMA: 
SAV_2595(add2)
SGR: 
SGB: 
SCB: 
SSX: 
SVL: 
SCT: 
SCY: 
SFA: 
SBH: 
SBI_03435(add1)
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
SALS: 
STRP: 
SFI: 
SCI: 
SRC: 
SALU: 
SALL: 
SLV: 
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
SXI: 
STRM: 
STRC: 
SAMB: 
SPRI: 
SCZ: 
SCX: 
SRW: 
STRF: 
KSK: 
KSE_28020(add1)
NCA: 
KFL: 
PSIM: 
AER: 
NDA: 
NAL: 
SRO: 
FRA: 
FRE: 
FRI: 
FAL: 
FSY: 
ACE: 
NML: 
SEN: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
ALU: 
AMI: 
KPHY: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
AMS: 
ASE: 
ACPL_6558(add2)
ACTN: 
L083_6087(add2)
AFS: 
CAI: 
SNA: 
CWO: 
AYM: 
CAP: 
ABA: 
ACM: 
GMA: 
TRS: 
 » show all
Taxonomy
Reference
1  [PMID:21098241]
  Authors
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T
  Title
Diversity of the early step of the futalosine pathway.
  Journal
Antimicrob. Agents. Chemother. 55 (2011) 913-6.
  Sequence
[ace:Acel_0264] [sco:SCO5662]
Reference
2  [PMID:23972005]
  Authors
Goble AM, Toro R, Li X, Ornelas A, Fan H, Eswaramoorthy S, Patskovsky Y, Hillerich B, Seidel R, Sali A, Shoichet BK, Almo SC, Swaminathan S, Tanner ME, Raushel FM
  Title
Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes.
  Journal
Biochemistry. 52 (2013) 6525-36.
  Sequence
[ace:Acel_0264] [sma:SAV_2595] [nis:NIS_0429] [dra:DR_0824]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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