KEGG   ENZYME: 3.5.4.46Help
Entry
EC 3.5.4.46                 Enzyme                                 

Name
cAMP deaminase;
cyclic adenylate deaminase;
CadD
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
3',5'-cyclic AMP aminohydrolase
Reaction(IUBMB)
3',5'-cyclic AMP + H2O = 3',5'-cyclic IMP + NH3 [RN:R11619]
Reaction(KEGG)
Substrate
3',5'-cyclic AMP [CPD:C00575];
H2O [CPD:C00001]
Product
3',5'-cyclic IMP [CPD:C00943];
NH3 [CPD:C00014]
Comment
Requires Zn2+. The enzyme, isolated from the bacterium Leptospira interrogans, is specific for cAMP.
History
EC 3.5.4.46 created 2017
Orthology
K21589  
cAMP deaminase
Genes
LIL: 
LA_3783(add)
LIE: 
LIC: 
LIS: 
LIL_10465(add1)
LBJ: 
LBL: 
LBI: 
LBF: 
LST: 
LAJ: 
Taxonomy
Reference
1  [PMID:24074367]
  Authors
Goble AM, Feng Y, Raushel FM, Cronan JE
  Title
Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation.
  Journal
ACS. Chem. Biol. 8 (2013) 2622-9.
  Sequence
[lic:LIC_10459]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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