KEGG   ENZYME: 3.5.4.46Help
Entry
EC 3.5.4.46                 Enzyme                                 

Name
cAMP deaminase;
cyclic adenylate deaminase;
CadD
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
3',5'-cyclic AMP aminohydrolase
Reaction(IUBMB)
3',5'-cyclic AMP + H2O = 3',5'-cyclic IMP + NH3 [RN:R11619]
Reaction(KEGG)
Substrate
3',5'-cyclic AMP [CPD:C00575];
H2O [CPD:C00001]
Product
3',5'-cyclic IMP [CPD:C00943];
NH3 [CPD:C00014]
Comment
Requires Zn2+. The enzyme, isolated from the bacterium Leptospira interrogans, is specific for cAMP.
History
EC 3.5.4.46 created 2017
Orthology
K21589  cAMP deaminase
Genes
LIL: LA_3783(add)
LIE: LIF_A3030(add)
LIC: LIC_10459(add)
LIS: LIL_10465(add1)
LBJ: LBJ_0617(add)
LBL: LBL_2462(add)
LBI: LEPBI_I0038(add2)
LBF: LBF_0040(add)
LST: LSS_06689
LAJ: A0128_16525
Taxonomy
Reference
1  [PMID:24074367]
  Authors
Goble AM, Feng Y, Raushel FM, Cronan JE
  Title
Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation.
  Journal
ACS. Chem. Biol. 8 (2013) 2622-9.
  Sequence
[lic:LIC_10459]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.46
IUBMB Enzyme Nomenclature: 3.5.4.46
ExPASy - ENZYME nomenclature database: 3.5.4.46
BRENDA, the Enzyme Database: 3.5.4.46

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