KEGG   ENZYME: 3.5.4.8Help
Entry
EC 3.5.4.8                  Enzyme                                 

Name
aminoimidazolase;
4-aminoimidazole hydrolase;
4-aminoimidazole deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
4-aminoimidazole aminohydrolase
Reaction(IUBMB)
4-aminoimidazole + H2O = imidazol-4-one + NH3 [RN:R04731]
Reaction(KEGG)
Substrate
4-aminoimidazole [CPD:C05239];
H2O [CPD:C00001]
Product
imidazol-4-one [CPD:C06195];
NH3 [CPD:C00014]
Comment
Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].
History
EC 3.5.4.8 created 1961
Pathway
Purine metabolism
Reference
1  [PMID:13367024]
  Authors
PRICER WE Jr, RABINOWITZ JC.
  Title
Purine fermentation by Clostridium cylindrosporum.  V.  Formiminoglycine.
  Journal
J. Biol. Chem. 222 (1956) 537-54.
  Organism
Clostridium cylindrosporum
Reference
2
  Authors
Freter, K., Rabinowitz, J.C. and Witkop, B.
  Title
Labile Stoffwechselprodukte. V. Zur Biogenese des Formiminoglycins aus 4(5H)-imidazolon.
  Journal
Ann. Chem. 607 (1957) 174-187.
Reference
3  [PMID:786256]
  Authors
Vogels GD, Van der Drift C.
  Title
Degradation of purines and pyrimidines by microorganisms.
  Journal
Bacteriol. Rev. 40 (1976) 403-68.
  Organism
Clostridium acidiurici, Clostridium cylindrosporum
Reference
4  [PMID:8376322]
  Authors
DeMoll E, Auffenberg T.
  Title
Purine metabolism in Methanococcus vannielii.
  Journal
J. Bacteriol. 175 (1993) 5754-61.
  Organism
Methanococcus vannielii
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-17-6

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