KEGG   ENZYME: 3.5.5.5Help
Entry
EC 3.5.5.5                  Enzyme                                 

Name
arylacetonitrilase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In nitriles
BRITE hierarchy
Sysname
arylacetonitrile aminohydrolase
Reaction(IUBMB)
4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH3 [RN:R04140]
Reaction(KEGG)
R04140;
(other) R00540
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Substrate
4-chlorophenylacetonitrile [CPD:C03679];
H2O [CPD:C00001]
Product
4-chlorophenylacetate [CPD:C03077];
NH3 [CPD:C00014]
Comment
Requires thiol compounds. Also hydrolyses other 4-substituted phenylacetonitriles, thien-2-ylacetonitrile, tolylacetonitriles, and, more slowly, benzyl cyanide.
History
EC 3.5.5.5 created 1992
Pathway
Metabolic pathways
Reference
1
  Authors
Mauger, J., Nagasawa, T. and Yamada, H.
  Title
Occurrence of a novel nitrilase, arylacetonitrilase, in Alcaligenes faecalis JM3.
  Journal
Arch. Microbiol. 155 (1990) 1-6.
Reference
2  [PMID:2269298]
  Authors
Nagasawa T, Mauger J, Yamada H.
  Title
A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3. Purification and characterization.
  Journal
Eur. J. Biochem. 194 (1990) 765-72.
  Organism
Alcaligenes faecalis
  Sequence
[up:P20960]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
132053-06-6

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