KEGG   ENZYME: 3.5.99.3Help
Entry
EC 3.5.99.3                 Enzyme                                 

Name
hydroxydechloroatrazine ethylaminohydrolase;
AtzB;
hydroxyatrazine ethylaminohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy
Sysname
4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase
Reaction(IUBMB)
4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine [RN:R05559]
Reaction(KEGG)
R05559;
(other) R06966
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Substrate
4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine [CPD:C06552];
H2O [CPD:C00001]
Product
N-isopropylammelide [CPD:C06553];
ethylamine [CPD:C00797]
Comment
Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine.
History
EC 3.5.99.3 created 2000
Pathway
Atrazine degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K03382  
hydroxyatrazine ethylaminohydrolase
Genes
RET: 
REL: 
REI: 
REP: 
RLE: 
pRL100336(atzB)
RLT: 
RLG: 
RLB: 
RLU: 
RTR: 
RHL: 
RGA: 
CSH: 
DOR: 
DMI: 
AAU: 
SSM: 
SBU: 
SGP: 
 » show all
Taxonomy
Reference
1  [PMID:9055410]
  Authors
Boundy-Mills KL, de Souza ML, Mandelbaum RT, Wackett LP, Sadowsky MJ.
  Title
The atzB gene of Pseudomonas sp. strain ADP encodes the second enzyme of a novel atrazine degradation pathway.
  Journal
Appl. Environ. Microbiol. 63 (1997) 916-23.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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