KEGG   ENZYME: 3.5.99.4Help
Entry
EC 3.5.99.4                 Enzyme                                 

Name
N-isopropylammelide isopropylaminohydrolase;
AtzC
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy
Sysname
N-isopropylammelide isopropylaminohydrolase
Reaction(IUBMB)
N-isopropylammelide + H2O = cyanuric acid + isopropylamine [RN:R05560]
Reaction(KEGG)
R05560;
(other) R06967
Show
Substrate
N-isopropylammelide [CPD:C06553];
H2O [CPD:C00001]
Product
cyanuric acid [CPD:C06554];
isopropylamine [CPD:C06748]
Comment
Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopopylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine.
History
EC 3.5.99.4 created 2000
Pathway
Atrazine degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K08710  
N-isopropylammelide isopropylaminohydrolase
Genes
AAU: 
Taxonomy
Reference
1  [PMID:9422605]
  Authors
Sadowsky MJ, Tong Z, de Souza M, Wackett LP.
  Title
AtzC is a new member of the amidohydrolase protein superfamily and is homologous to other atrazine-metabolizing enzymes.
  Journal
J. Bacteriol. 180 (1998) 152-8.
  Organism
Pseudomonas sp.
  Sequence
[up:O52063]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
203810-02-0

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