2-aminomuconate deaminase;
amnD (gene name);
nbaF (gene name)

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds

2-aminomuconate aminohydrolase

2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3 [RN:R03887]

R03887

2-aminomuconate [CPD:C02220];
H2O [CPD:C00001]

2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.

1  [PMID:9471964]

He Z, Spain JC.

Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde.

Appl. Environ. Microbiol. 63 (1997) 4839-43.

Pseudomonas pseudoalcaligenes

2  [PMID:9573204]

He Z, Spain JC.

A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45.

J. Bacteriol. 180 (1998) 2502-6.

Pseudomonas pseudoalcaligenes

3  [PMID:11081795]

Takenaka S, Murakami S, Kim YJ, Aoki K

Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3.

Arch. Microbiol. 174 (2000) 265-72.

4  [PMID:12620844]

Muraki T, Taki M, Hasegawa Y, Iwaki H, Lau PC.

Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.

Appl. Environ. Microbiol. 69 (2003) 1564-72.