KEGG   ENZYME: 3.5.99.5Help
Entry
EC 3.5.99.5                 Enzyme                                 

Name
2-aminomuconate deaminase;
amnD (gene name);
nbaF (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy
Sysname
2-aminomuconate aminohydrolase
Reaction(IUBMB)
2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3 [RN:R03887]
Reaction(KEGG)
Substrate
2-aminomuconate [CPD:C02220];
H2O [CPD:C00001]
Product
(3E)-2-oxohex-3-enedioate;
NH3 [CPD:C00014]
Comment
2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.
History
EC 3.5.99.5 created 2000, modified 2012
Pathway
Tryptophan metabolism
Orthology
K15067  
2-aminomuconate deaminase
Genes
TMN: 
NHE: 
DDI: 
DPP: 
SLQ: 
RHD: 
DJI: 
PPW: 
PKC: 
PKB_3260(amnd1) PKB_3608(amnd3)
SWD: 
HCS: 
KKO: 
REU: 
RME: 
Rmet_5211(amnD)
BUR: 
BCJ: 
BCAM2131(nbaF)
BXE: 
Bxe_A1148(amnD)
BPY: 
BUG: 
BRH: 
BPX: 
PPK: 
PPNO: 
PRB: 
BAV: 
BAV0553(amnE)
AXY: 
AXO: 
AXN: 
PUT: 
CDN: 
POL: 
MXA: 
MFU: 
MSD: 
CCX: 
SUR: 
SWI: 
RER: 
REY: 
REQ: 
SCB: 
SSX: 
KFL: 
SRO: 
FRI: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
ABA: 
CTM: 
HSW: 
HYM: 
MTT: 
CAT: 
KDI: 
LAN: 
ASL: 
NDO: 
POM: 
FTE: 
OHO: 
 » show all
Taxonomy
Reference
1  [PMID:9471964]
  Authors
He Z, Spain JC.
  Title
Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde.
  Journal
Appl. Environ. Microbiol. 63 (1997) 4839-43.
Reference
2  [PMID:9573204]
  Authors
He Z, Spain JC.
  Title
A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45.
  Journal
J. Bacteriol. 180 (1998) 2502-6.
  Sequence
[up: P81593]
Reference
3  [PMID:11081795]
  Authors
Takenaka S, Murakami S, Kim YJ, Aoki K
  Title
Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3.
  Journal
Arch. Microbiol. 174 (2000) 265-72.
  Sequence
[up:Q9KWS2]
Reference
4  [PMID:12620844]
  Authors
Muraki T, Taki M, Hasegawa Y, Iwaki H, Lau PC.
  Title
Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.
  Journal
Appl. Environ. Microbiol. 69 (2003) 1564-72.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
201098-29-5

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