Entry |
|
Name |
glucosamine-6-phosphate deaminase;
glucosaminephosphate isomerase;
glucosamine-6-phosphate isomerase;
phosphoglucosaminisomerase;
glucosamine phosphate deaminase;
aminodeoxyglucosephosphate isomerase;
phosphoglucosamine isomerase;
2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
|
Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
 |
Sysname |
2-amino-2-deoxy-alpha-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
|
Reaction(IUBMB) |
alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3 [RN: R00765]
|
Reaction(KEGG) |
|
Substrate |
alpha-D-glucosamine 6-phosphate;
H2O [CPD: C00001]
|
Product |
|
Comment |
The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
|
History |
EC 3.5.99.6 created 1961 as EC 5.3.1.10, transferred 2000 to EC 3.5.99.6
|
Pathway |
ec00520 | Amino sugar and nucleotide sugar metabolism |
|
Orthology |
K02564 | glucosamine-6-phosphate deaminase |
|
Genes |
» show all
 |
Reference |
|
Authors |
WOLFE JB, BRITTON BB, NAKADA HI. |
Title |
Glucosamine degradation by Escherichia coli. III. Isolation and studies of phosphoglucosaminisomerase. |
Journal |
Arch. Biochem. Biophys. 66 (1957) 333-9. |
Reference |
|
Authors |
COMB DG, ROSEMAN S. |
Title |
Glucosamine metabolism. IV. Glucosamine-6-phosphate deaminase. |
Journal |
J. Biol. Chem. 232 (1958) 807-27. |
Reference |
|
Authors |
PATTABIRAMAN TN, BACHHAWAT BK. |
Title |
Purification of glucosamine 6-phosphate deaminase from human brain. |
Journal |
Biochim. Biophys. Acta. 54 (1961) 273-83. |
Reference |
|
Authors |
Liu C, Li D, Liang YH, Li LF, Su XD |
Title |
Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex. |
Journal |
J. Mol. Biol. 379 (2008) 73-81. |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.5.99.6 |
ExPASy - ENZYME nomenclature database: | 3.5.99.6 |
|