KEGG   ENZYME: 3.5.99.9Help
Entry
EC 3.5.99.9                 Enzyme                                 

Name
2-nitroimidazole nitrohydrolase;
NnhA;
2NI nitrohydrolase;
2NI denitrase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy
Sysname
2-nitroimidazole nitrohydrolase
Reaction(IUBMB)
2-nitroimidazole + H2O = imidazol-2-one + nitrite [RN:R10133]
Reaction(KEGG)
Substrate
2-nitroimidazole [CPD:C14531];
H2O [CPD:C00001]
Product
imidazol-2-one [CPD:C20382];
nitrite [CPD:C00088]
Comment
The enzyme catalyses the initial step in the biodegradation of 2-nitroimidazole by the soil bacterium Mycobacterium sp. JS330
History
EC 3.5.99.9 created 2012
Orthology
K20764  
2-nitroimidazole nitrohydrolase
Reference
1  [PMID:21244596]
  Authors
Qu Y, Spain JC
  Title
Catabolic pathway for 2-nitroimidazole involves a novel nitrohydrolase that also  confers drug resistance.
  Journal
Environ. Microbiol. 13 (2011) 1010-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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