KEGG   ENZYME: 3.6.1.18Help
Entry
EC 3.6.1.18                 Enzyme                                 

Name
FAD diphosphatase;
FAD pyrophosphatase;
riboflavin adenine dinucleotide pyrophosphatase;
flavin adenine dinucleotide pyrophosphatase;
riboflavine adenine dinucleotide pyrophosphatase;
flavine adenine dinucleotide pyrophosphatase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
FAD nucleotidohydrolase
Reaction(IUBMB)
FAD + H2O = AMP + FMN [RN:R00160]
Reaction(KEGG)
Substrate
FAD [CPD:C00016];
H2O [CPD:C00001]
Product
AMP [CPD:C00020];
FMN [CPD:C00061]
Comment
The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC 3.6.1.9 nucleotide diphosphatase.
History
EC 3.6.1.18 created 1972
Pathway
Riboflavin metabolism
Reference
1  [PMID:5810832]
  Authors
Ravindranath SD, Rao NA.
  Title
Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus.
  Journal
Arch. Biochem. Biophys. 133 (1969) 54-9.
  Organism
Phaseolus radiatus
Reference
2  [PMID:2848456]
  Authors
Shin HJ, Mego JL.
  Title
A rat liver lysosomal membrane flavin-adenine dinucleotide phosphohydrolase: purification and characterization.
  Journal
Arch. Biochem. Biophys. 267 (1988) 95-103.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37289-30-8

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