KEGG ENZYME: 3.6.1.45

ENZYME: 3.6.1.45

Entry

EC 3.6.1.45 Enzyme

Name

UDP-sugar diphosphatase;
nucleosidediphosphate-sugar pyrophosphatase;
nucleosidediphosphate-sugar diphosphatase;
UDP-sugar hydrolase;
UDP-sugar pyrophosphatase

Class

Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides

Sysname

UDP-sugar sugarphosphohydrolase

Reaction(IUBMB)

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate [RN:R03986]

Reaction(KEGG)

R03986 > R00287

Substrate

UDP-sugar [CPD:C05227];
H2O [CPD:C00001]

Product

UMP [CPD:C00105];
alpha-D-aldose 1-phosphate [CPD:C00991]

Comment

A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5'-nucleotidase (see EC 3.1.3.5) activity.

Orthology

K08077	UDP-sugar diphosphatase
K11751	5'-nucleotidase / UDP-sugar diphosphatase

Genes

HSA:	256281(NUDT14)
PTR:	737747(NUDT14)
PPS:	100990874(NUDT14)
GGO:	101133135
PON:	100448121(NUDT14)
MCC:	699003
MMU:	66174(Nudt14)
RNO:	299346(Nudt14)
CFA:	612707(NUDT14)
AML:	100465035
FCA:	101089450
BTA:	100126049(NUDT14)
SSC:	397008(UGPP)
ECB:	100063626
OAA:	100088672
GGA:	423501(NUDT14)
MGP:	100540898
TGU:	100226762(NUDT14)
ACS:	100553159
DRE:	559149(nudt14)
TRU:	101077957
OLA:	101155980
SPU:	582592
DGR:	Dgri_GH21306
DVI:	Dvir_GJ23175
AGA:	AgaP_AGAP004158
AAG:	AaeL_AAEL001092
NVI:	100117070(NV15431)
TCA:	664500
API:	100160857
PHU:	Phum_PHUM419690
ISC:	IscW_ISCW013348
TSP:	Tsp_11973
SMM:	Smp_003130
NVE:	NEMVE_v1g170741
HMG:	100202798
TAD:	TRIADDRAFT_57300
AQU:	100641248
CRE:	CHLREDRAFT_159943
VCN:	VOLCADRAFT_119828
AFM:	AFUA_4G02960
NGR:	NAEGRDRAFT_71452(FM168) NAEGRDRAFT_72430
ECO:	b0480(ushA)
ECJ:	Y75_p0467(ushA)
ECD:	ECDH10B_0436(ushA)
EBW:	BWG_0361(ushA)
ECOK:	ECMDS42_0379(ushA)
ECE:	Z0599(ushA)
ECS:	ECs0533(ushA)
ECF:	ECH74115_0572(ushA)
ETW:	ECSP_0547(ushA)
ELX:	CDCO157_0521(ushA)
EOJ:	ECO26_0515(ushA)
EOI:	ECO111_0515(ushA)
EOH:	ECO103_0456(ushA)
ECG:	E2348C_0415(ushA)
EOK:	G2583_0592(ushA)
ELR:	ECO55CA74_02890(ushA)
ECC:	c0600(ushA)
ECP:	ECP_0541(ushA)
ECI:	UTI89_C0508(ushA)
ECV:	APECO1_1535(ushA)
ECX:	EcHS_A0557(ushA)
ECW:	EcE24377A_0519(ushA)
ECM:	EcSMS35_0524(ushA)
ECY:	ECSE_0505(ushA)
ECR:	ECIAI1_0483(ushA)
ECQ:	ECED1_0504(ushA)
ECK:	EC55989_0493(ushA)
EOC:	CE10_0452(ushA)
EUM:	ECUMN_0519(ushA)
ECZ:	ECS88_0477(ushA)
ELO:	EC042_0520(ushA)
ELN:	NRG857_02275(ushA)
ELH:	ETEC_0532
ESE:	ECSF_0440
ESO:	O3O_06205(ushA)
ESM:	O3M_19065(ushA)
ESL:	O3K_19090(ushA)
ECL:	EcolC_3136(ushA)
EBR:	ECB_00431(ushA)
EBD:	ECBD_3176(ushA)
EKO:	EKO11_3367
EKF:	KO11_21180(ushA)
EAB:	ECABU_c05640(ushA)
EDH:	EcDH1_3130
EDJ:	ECDH1ME8569_0464(ushA)
EIH:	ECOK1_0462(ushA)
ENA:	ECNA114_0459(ushA)
ELU:	UM146_14960(ushA)
EUN:	UMNK88_533
ELW:	ECW_m0552(ushA)
ELL:	WFL_02740(ushA)
ELC:	i14_0575(ushA)
ELD:	i02_0575(ushA)
ELP:	P12B_c0492(ushA)
EBL:	ECD_00431(ushA)
EBE:	B21_00436(ushA)
ELF:	LF82_2386(ushA)
ECOA:	APECO78_05920(ushA)
EFE:	EFER_0532(ushA)
EBT:	EBL_c28440(ushA)
STM:	STM0494(ushA)
SEO:	STM14_0582(ushA)
SEV:	STMMW_05641
SEY:	SL1344_0487(ushA)
SEM:	STMDT12_C05580(ushA)
SEJ:	STMUK_0501(ushA)
SEB:	STM474_0515(ushA)
SEF:	UMN798_0539(ushA)
SETU:	STU288_11900(ushA)
SPT:	SPA2228(ushA)
SEK:	SSPA2071(ushA)
SPQ:	SPAB_03073(ushA)
SEI:	SPC_0509(ushA)
SEC:	SC0536(ushA)
SEH:	SeHA_C0601(ushA)
SHB:	SU5_01188
SEE:	SNSL254_A0547(ushA)
SEW:	SeSA_A0557(ushA)
SEA:	SeAg_B0540(ushA)
SED:	SeD_A0542(ushA)
SEG:	SG0505(ushA)
SEL:	SPUL_2466(ushA)
SET:	SEN0475(ushA)
SENJ:	CFSAN001992_08725(ushA)
SES:	SARI_02439(ushA)
SBG:	SBG_0440(ushA)
YPA:	YPA_2586
YPN:	YPN_0998
YPP:	YPDSF_2729
YPZ:	YPZ3_2724
YPT:	A1122_10500
YPD:	YPD4_2712
YPX:	YPD8_2704
YPI:	YpsIP31758_3032(ushA)
YEN:	YE3066(ushA)
YEP:	YE105_C1187
YEY:	Y11_19841
SFL:	CP0185(ushA) SF0425(ushA)
SFX:	S0432(ushA)
SFE:	SFxv_0470(ushA) SFxv_5032(ushA)
SSN:	SSON_0469(ushA) SSON_P147(ushA)
SSJ:	SSON53_02510(ushA) SSON53_27363(ushA)
SBO:	SBO_0382(ushA)
SBC:	SbBS512_A0223(ushA) SbBS512_E0415(ushA)
SDY:	SDY_0438(ushA) SDY_P064(ushA)
ECA:	ECA1184(ushA)
PCT:	PC1_1083
PCC:	PCC21_011160
PWA:	Pecwa_3228(ushA)
PEC:	W5S_3225
ETA:	ETA_24600(ushA)
EPY:	EpC_25690(ushA)
EPR:	EPYR_02787(ushA)
EAM:	EAMY_1032(ushA)
EAY:	EAM_1039(ushA)
EBI:	EbC_10580(ushA)
ERJ:	EJP617_21610(ushA)
PLU:	plu3828(ushA)
PAY:	PAU_00979(ushA)
ENT:	Ent638_0959(ushA)
ENC:	ECL_01250
ENO:	ECENHK_05400
ECLO:	ENC_22470
ESC:	Entcl_3311
EEC:	EcWSU1_01016(ushA)
ENL:	A3UG_05365
EAS:	Entas_0991
EAE:	EAE_13035(ushA)
EAR:	ST548_p5689
ESA:	ESA_02784(ushA)
CSK:	ES15_2874(ushA)
CSZ:	CSSP291_13235(ushA)
CTU:	CTU_10880(ushA)
KPN:	KPN_00461(ushA)
KPU:	KP1_1339(ushA)
KPM:	KPHS_12090
KPP:	A79E_3819
KPE:	KPK_4219(ushA)
KPO:	KPN2242_04715(ushA)
KVA:	Kvar_3920
KOX:	KOX_13075(ushA)
CKO:	CKO_02669(ushA)
CRO:	ROD_05381(ushA)
SPE:	Spro_1147(ushA)
SRR:	SerAS9_1075
SRS:	SerAS12_1075
SRA:	SerAS13_1075
SMAF:	D781_1070
SMW:	SMWW4_v1c10860(ushA)
PMR:	PMI2177(ushA)
EIC:	NT01EI_1132
ETR:	ETAE_1034
ETD:	ETAF_0962
ETC:	ETAC_04925(ushA)
DDA:	Dd703_1027(ushA)
DDC:	Dd586_1068
DDD:	Dda3937_04493(ushA)
DZE:	Dd1591_3032(ushA)
XBO:	XBJ1_1598(ushA)
XNE:	XNC1_0942(ushA)
PAM:	PANA_1037(ushA)
PLF:	PANA5342_3261(ushA)
PAJ:	PAJ_0362(ushA)
PAQ:	PAGR_g3171
PVA:	Pvag_0420(ushA)
PAO:	Pat9b_0990
PSI:	S70_04885(ushA)
MMK:	MU9_3208
ROR:	RORB6_12920(ushA)
EBF:	D782_3343
HAP:	HAPS_0478(ushA)
HPR:	PARA_12590
PMU:	PM1193(ushA)
PMV:	PMCN06_2270(ushA)
PUL:	NT08PM_2274
MSU:	MS1658(ushA)
MHT:	D648_13600
MHQ:	D650_11850
MHX:	MHH_c19800(ushA)
APL:	APL_0769(ushA)
APJ:	APJL_0771(ushA)
APA:	APP7_0830
ASU:	Asuc_1925(ushA)
ASI:	ASU2_03130(ushA)
GAN:	UMN179_01557
BTO:	WQG_12520
VCH:	VC2174(ushA)
VCE:	Vch1786_I1662(ushA)
VCJ:	VCD_002204(ushA)
VCO:	VC0395_A1751(ushA)
VCR:	VC395_2288(ushA)
VCM:	VCM66_2097(ushA)
VCI:	O3Y_10460(ushA)
VCL:	VCLMA_A1901
VVU:	VV1_0248
VVY:	VV0936(ushA)
VVM:	VVMO6_02288
VPA:	VP0748(ushA) VP1207(ushA)
VPB:	VPBB_0717 VPBB_1131
VHA:	VIBHAR_01256(ushA) VIBHAR_02665(ushA)
VSP:	VS_0757(ushA)
VEX:	VEA_003789 VEA_004198
VEJ:	VEJY3_03440(ushA) VEJY3_05835
VFU:	vfu_A01148
VFI:	VF_0778(ushA)
VFM:	VFMJ11_0814(ushA)
VSA:	VSAL_I0800(ushA)
PPR:	PBPRA2836(ushA)
VAN:	VAA_03497
SON:	SO_2001(ushA)
SDN:	Sden_2137(ushA)
SFR:	Sfri_2309(ushA)
SAZ:	Sama_2021(ushA)
SBL:	Sbal_2583(ushA)
SBM:	Shew185_2625(ushA)
SBN:	Sbal195_2700(ushA)
SBP:	Sbal223_1760(ushA)
SBT:	Sbal678_2705
SBS:	Sbal117_2720
SBB:	Sbal175_1744
SLO:	Shew_2135(ushA)
SPC:	Sputcn32_2311(ushA)
SHP:	Sput200_2337
SSE:	Ssed_1926(ushA) Ssed_2669(ushA)
SPL:	Spea_1908(ushA)
SHE:	Shewmr4_2264(ushA)
SHM:	Shewmr7_2336(ushA)
SHN:	Shewana3_2454(ushA)
SHW:	Sputw3181_1697(ushA)
SHL:	Shal_2226(ushA) Shal_2390(ushA) Shal_3368(ushA)
SWD:	Swoo_1951(ushA) Swoo_1952(ushA)
SWP:	swp_2845(ushA) swp_4438(ushA)
SVO:	SVI_2596(nutA)
PHA:	PSHAb0345(ushA)
PSM:	PSM_B0412
PIN:	Ping_2695(ushA) Ping_3661 Ping_3682
HCH:	HCH_02315(ushA)
MMW:	Mmwyl1_4357(ushA)
MME:	Marme_4050
MPC:	Mar181_3437
AVR:	B565_3205
CVI:	CV_1743(ushA)
HPY:	HP0507
HEO:	C694_02605
HPJ:	jhp0457
HPA:	HPAG1_0481
HPS:	HPSH_04390
HHP:	HPSH112_04520
HHQ:	HPSH169_02600
HHR:	HPSH417_02410
HPG:	HPG27_465
HPP:	HPP12_0513
HPB:	HELPY_0846
HPL:	HPB8_691(nudT14)
HPC:	HPPC_02485
HCA:	HPPC18_02415
HPM:	HPSJM_02530
HPE:	HPELS_04085
HPO:	HMPREF4655_21098(nudT14)
HPI:	hp908_0503
HPQ:	hp2017_0484
HPW:	hp2018_0486
HPU:	HPCU_02760
HEF:	HPF16_0848
HPF:	HPF30_0817
HEQ:	HPF32_0487
HEX:	HPF57_0537
HPT:	HPSAT_04240
HPZ:	HPKB_0833
HPV:	HPV225_0502
HPX:	HMPREF0462_0915(nudT14)
HEN:	HPSNT_02605
HPH:	HPLT_02505
HEG:	HPGAM_02585
HPN:	HPIN_04370
HEP:	HPPN120_02450
HEU:	HPPN135_02480
HES:	HPSA_02445
HCN:	HPB14_04185
HPD:	KHP_0811
HEY:	MWE_1018
HER:	C695_02605
HEI:	C730_02605
HPYA:	HPAKL117_02530
HPYK:	HPAKL86_03860
HPYO:	HPOK113_0489
HPYL:	HPOK310_0821
HHE:	HH0871
HAC:	Hac_0900
HMS:	HMU02810
HFE:	HFELIS_11830
HBI:	HBZC1_01490
HCE:	HCW_05815
HCM:	HCD_05525
HCB:	HCBAA847_1974
WSU:	WS0265
TDN:	Suden_0369
SUA:	Saut_0335
SKU:	Sulku_2177
SULR:	B649_10285
CJE:	Cj0447
CJB:	BN148_0447
CJJ:	CJJ81176_0472
CJU:	C8J_0420
CJN:	ICDCCJ_410
CJI:	CJSA_0417
CJM:	CJM1_0429
CJS:	CJS3_0439
CJP:	A911_02180
CJR:	CJE0497
CJD:	JJD26997_1492
CFF:	CFF8240_0698 CFF8240_1753
CCV:	CCV52592_0730
CHA:	CHAB381_1625
CCO:	CCC13826_1333
CLA:	Cla_1033
ABU:	Abu_0863
ABT:	ABED_0786
ANT:	Arnit_2170
ARC:	ABLL_1082
SDL:	Sdel_1588
SBA:	Sulba_1655
NSA:	Nitsa_0206
NIS:	NIS_0345
SUN:	SUN_2127
NAM:	NAMH_1241
MMO:	MMOB0990(ushA)
TBE:	Trebr_0065 Trebr_2434
TAZ:	TREAZ_3585
TPI:	TREPR_1357 TREPR_2839
SSM:	Spirs_1043
BHY:	BHWA1_02618(ushA)
BIP:	Bint_0845
OSP:	Odosp_1235
STR:	Sterm_0320
TAI:	Taci_0441
TMA:	TM1878(ushA)
TPT:	Tpet_0919(ushA)
TLE:	Tlet_0870(ushA)
TRQ:	TRQ2_0941(ushA)
TNA:	CTN_0814(ushA)
TNP:	Tnap_0635
TTA:	Theth_1585
TME:	Tmel_0123(ushA)
TAF:	THA_358(ushA)
FNO:	Fnod_0639(ushA)
FPE:	Ferpe_0915
PMO:	Pmob_0601(ushA)
KOL:	Kole_0902(ushA)
MPZ:	Marpi_1306
MPG:	Theba_1342
HWA:	HQ2723A(ushA)
NPH:	NP1854A(ushA_1) NP2590A(ushA_2)

» show all

Reference

1 [PMID:2548058]

Authors

Garrett AR, Johnson LA, Beacham IR.

Title

Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase.

Journal

Mol. Microbiol. 3 (1989) 177-86.

Organism

Salmonella typhimurium

Reference

2 [PMID:5337593]

Authors

Glaser L, Melo A, Paul R.

Title

Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor.

Journal

J. Biol. Chem. 242 (1967) 1944-54.

Organism

Escherichia coli [GN:eco]

Other DBs

ExplorEnz - The Enzyme Database:

3.6.1.45

IUBMB Enzyme Nomenclature:

3.6.1.45

ExPASy - ENZYME nomenclature database:

3.6.1.45

BRENDA, the Enzyme Database:

3.6.1.45

CAS:

55354-38-6

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Ontology (2)   
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Gene (3966)   
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Protein sequence (1177)   
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