KEGG   ENZYME: 3.6.1.53Help
Entry
EC 3.6.1.53                 Enzyme                                 

Name
Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase;
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase;
ADPRibase-Mn
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
CDP-choline phosphohydrolase
Reaction(IUBMB)
(1) CDP-choline + H2O = CMP + phosphocholine [RN:R09538];
(2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054]
Reaction(KEGG)
Substrate
CDP-choline [CPD:C00307];
H2O [CPD:C00001];
ADP-D-ribose [CPD:C00301]
Product
CMP [CPD:C00055];
phosphocholine [CPD:C00588];
AMP [CPD:C00020];
D-ribose 5-phosphate [CPD:C00117]
Comment
Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. In rat, the enzyme is found predominantly in thymus and spleen.
History
EC 3.6.1.53 created 2008
Orthology
K01517  
manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Genes
HSA: 
56985(ADPRM)
PTR: 
745728(ADPRM)
PPS: 
GGO: 
101139187(ADPRM)
PON: 
100436862(C17H17orf48)
MCC: 
717991(ADPRM)
MCF: 
102147209(ADPRM)
MMU: 
66358(Adprm)
RNO: 
287406(Adprm)
CGE: 
HGL: 
101700336(Adprm)
TUP: 
102478915(ADPRM)
CFA: 
479504(ADPRM)
AML: 
FCA: 
101085161(ADPRM)
PTG: 
102965979(ADPRM)
BTA: 
534038(ADPRM)
BOM: 
102283155(ADPRM)
PHD: 
102324948(ADPRM)
CHX: 
102181988(ADPRM)
SSC: 
100519388(ADPRM)
CFR: 
102511144(ADPRM)
ECB: 
100073085(ADPRM)
MYB: 
102260362(ADPRM)
MYD: 
102759013(ADPRM)
PALE: 
102882253(ADPRM)
MDO: 
SHR: 
100918137(C4H17orf48)
OAA: 
GGA: 
768578(C17ORF48)
MGP: 
TGU: 
100232304(ADPRM)
FAB: 
PHI: 
102102216(ADPRM)
APLA: 
101805114(ADPRM)
FPG: 
101917811(ADPRM)
FCH: 
102046962(ADPRM)
CLV: 
102096818(ADPRM)
ASN: 
102378502(ADPRM)
PSS: 
102454910(ADPRM)
CMY: 
102947863(ADPRM)
ACS: 
XLA: 
380120(adprm)
XTR: 
493375(adprm)
DRE: 
393393(adprm)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102354487(ADPRM)
BFO: 
ISC: 
HMG: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0012s09120g(POPTRDRAFT_662067)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os07t0688000-01(Os07g0688000)
OBR: 
BDI: 
SBI: 
SORBI_07g024380(SORBIDRAFT_07g024380)
ZMA: 
SITA: 
ATR: 
s00174p00058760(AMTR_s00174p00058760)
SMO: 
PPP: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
TPS: 
PIF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:7819284]
  Authors
Canales J, Pinto RM, Costas MJ, Hernandez MT, Miro A, Bernet D, Fernandez A, Cameselle JC
  Title
Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg(2+)-and/or Mn(2+)-dependent hydrolases acting on ADP-ribose.
  Journal
Biochim. Biophys. Acta. 1246 (1995) 167-77.
Reference
2  [PMID:18352857]
  Authors
Canales J, Fernandez A, Ribeiro JM, Cabezas A, Rodrigues JR, Cameselle JC, Costas MJ
  Title
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
  Journal
Biochem. J. 413 (2008) 103-13.
  Organism
Rattus norvegicus
  Sequence
[rno:287406]
Reference
3  [PMID:19379742]
  Authors
Canales J, Fernandez A, Rodrigues JR, Ferreira R, Ribeiro JM, Cabezas A, Costas MJ, Cameselle JC
  Title
Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.
  Journal
FEBS. Lett. 583 (2009) 1593-8.
Reference
4  [PMID:22848751]
  Authors
Rodrigues JR, Fernandez A, Canales J, Cabezas A, Ribeiro JM, Costas MJ, Cameselle JC
  Title
Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.
  Journal
PLoS. One. 7 (2012) e42249.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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