KEGG   ENZYME: 3.6.1.56Help
Entry
EC 3.6.1.56                 Enzyme                                 

Name
2-hydroxy-dATP diphosphatase;
NUDT1;
MTH1;
MTH2;
oxidized purine nucleoside triphosphatase;
(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
2-hydroxy-dATP diphosphohydrolase
Reaction(IUBMB)
2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate [RN:R09833]
Reaction(KEGG)
Substrate
2-hydroxy-dATP [CPD:C19969];
H2O [CPD:C00001]
Product
2-hydroxy-dAMP [CPD:C19970];
diphosphate [CPD:C00013]
Comment
The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [3].
History
EC 3.6.1.56 created 2011
Orthology
K17816  
8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase
Genes
HSA: 
4521(NUDT1)
PTR: 
463225(NUDT1)
PPS: 
100976009(NUDT1)
GGO: 
101142144(NUDT1)
PON: 
100453694(NUDT1)
NLE: 
100588684(NUDT1)
MCC: 
713078(NUDT1)
MCF: 
102115722(NUDT1)
RRO: 
104664957(NUDT1)
CJC: 
100403627(NUDT1)
MMU: 
17766(Nudt1)
RNO: 
117260(Nudt1)
CGE: 
100770207(Nudt1)
NGI: 
103748680(Nudt1)
HGL: 
101712324(Nudt1)
OCU: 
100348373(NUDT1)
TUP: 
CFA: 
489894(NUDT1)
AML: 
100478273(NUDT1)
UMR: 
103669938(NUDT1)
FCA: 
101091068(NUDT1)
PTG: 
102960769(NUDT1)
BTA: 
525496(NUDT1)
BOM: 
102283912(NUDT1)
PHD: 
102324548(NUDT1)
CHX: 
102170291(NUDT1)
OAS: 
101119103(NUDT1)
SSC: 
100624718(NUDT1)
CFR: 
102505397(NUDT1)
BACU: 
102999519(NUDT1)
LVE: 
103088420(NUDT1)
ECB: 
100059629(NUDT1)
MYB: 
102258594(NUDT1)
MYD: 
102773538(NUDT1)
MDO: 
100029290(NUDT1)
SHR: 
100930683(NUDT1)
GGA: 
416467(NUDT1)
MGP: 
CJO: 
APLA: 
101796502(NUDT1)
TGU: 
100219364(NUDT1)
GFR: 
102043288(NUDT1)
FAB: 
101817554(NUDT1)
PHI: 
102103488(NUDT1)
CCW: 
104684817(NUDT1)
FPG: 
101910266(NUDT1)
FCH: 
102058149(NUDT1)
CLV: 
102089493(NUDT1)
AAM: 
106499956(NUDT1)
ASN: 
102382097(NUDT1)
AMJ: 
102569822(NUDT1)
PSS: 
102462474(NUDT1)
CMY: 
102932983(NUDT1)
ACS: 
100564610(nudt1)
PBI: 
103052574(NUDT1)
GJA: 
107119570(NUDT1)
XTR: 
448146(nudt1)
DRE: 
406727(nudt1)
TRU: 
101067910(nudt1)
MZE: 
101466444(nudt1)
OLA: 
101169700(nudt1)
XMA: 
102231230(nudt1)
LCM: 
102349971(NUDT1)
CMK: 
103186606(nudt1)
BFO: 
SPU: 
SKO: 
AME: 
410765(GB18817)
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
TSP: 
CRG: 
OBI: 
NVE: 
HMG: 
TAD: 
AQU: 
MPP: 
SHS: 
PSQ: 
ADL: 
FME: 
GTR: 
MRR: 
ABP: 
AGABI1DRAFT108808(AGABI1DRAFT_108808)
ABV: 
AGABI2DRAFT187240(AGABI2DRAFT_187240)
CPUT: 
SRE: 
DFA: 
ACAN: 
AAF: 
PSOJ: 
SPAR: 
HSU: 
HSF: 
 » show all
Taxonomy
Reference
1  [PMID:8226881]
  Authors
Sakumi K, Furuichi M, Tsuzuki T, Kakuma T, Kawabata S, Maki H, Sekiguchi M
  Title
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
  Journal
J. Biol. Chem. 268 (1993) 23524-30.
  Sequence
[hsa:4521]
Reference
2  [PMID:7592783]
  Authors
Kakuma T, Nishida J, Tsuzuki T, Sekiguchi M
  Title
Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution.
  Journal
J. Biol. Chem. 270 (1995) 25942-8.
  Sequence
[mmu:17766]
Reference
3  [PMID:10373420]
  Authors
Fujikawa K, Kamiya H, Yakushiji H, Fujii Y, Nakabeppu Y, Kasai H
  Title
The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein.
  Journal
J. Biol. Chem. 274 (1999) 18201-5.
  Sequence
[hsa:4521]
Reference
4  [PMID:11756418]
  Authors
Sakai Y, Furuichi M, Takahashi M, Mishima M, Iwai S, Shirakawa M, Nakabeppu Y
  Title
A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP  by human MTH1.
  Journal
J. Biol. Chem. 277 (2002) 8579-87.
  Sequence
[hsa:4521]
Reference
5  [PMID:11139615]
  Authors
Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H
  Title
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.
  Journal
Nucleic. Acids. Res. 29 (2001) 449-54.
  Sequence
[hsa:4521]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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