KEGG   ENZYME: 3.6.1.6Help
Entry
EC 3.6.1.6                  Enzyme                                 

Name
nucleoside diphosphate phosphatase;
nucleoside-diphosphatase;
thiaminpyrophosphatase;
UDPase;
inosine diphosphatase;
adenosine diphosphatase;
IDPase;
ADPase;
adenosinepyrophosphatase;
guanosine diphosphatase;
guanosine 5'-diphosphatase;
inosine 5'-diphosphatase;
uridine diphosphatase;
uridine 5'-diphosphatase;
type B nucleoside diphosphatase;
GDPase;
CDPase;
nucleoside 5'-diphosphatase;
type L nucleoside diphosphatase;
NDPase;
nucleoside diphosphate phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
nucleoside-diphosphate phosphohydrolase
Reaction(IUBMB)
a nucleoside diphosphate + H2O = a nucleoside phosphate + phosphate [RN:R00329]
Reaction(KEGG)
Substrate
nucleoside diphosphate [CPD:C00454];
H2O [CPD:C00001]
Product
nucleoside phosphate [CPD:C01329];
phosphate [CPD:C00009]
Comment
The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate. Specificity depends on species and isoform.
History
EC 3.6.1.6 created 1961
Pathway
Purine metabolism
Pyrimidine metabolism
Orthology
K01511  
ectonucleoside triphosphate diphosphohydrolase 5/6
K12304  
soluble calcium-activated nucleotidase 1
K12305  
ectonucleoside triphosphate diphosphohydrolase 4
Genes
HSA: 
124583(CANT1) 955(ENTPD6) 957(ENTPD5) 9583(ENTPD4)
PTR: 
453027(ENTPD5) 458146(ENTPD6) 464056(ENTPD4) 468345(CANT1)
PPS: 
100969324(ENTPD4) 100974659(CANT1) 100975707(ENTPD5) 100985458(ENTPD6)
GGO: 
101126430(ENTPD6) 101142724(ENTPD5) 101148282(CANT1) 101148704(ENTPD4)
PON: 
100433776(ENTPD4) 100449249(ENTPD6) 100453014(ENTPD5) 100454763(CANT1)
NLE: 
100601352(CANT1) 100603393(ENTPD6) 100604246(ENTPD4) 100604959(ENTPD5)
MCC: 
698503(ENTPD5) 705663(ENTPD6) 710935(CANT1) 717197(ENTPD4)
MCF: 
102118635(ENTPD5) 102127579(CANT1) 102133506(ENTPD6) 102139183(ENTPD4)
CJC: 
100394992(ENTPD5) 100395619(ENTPD4) 100402589(CANT1) 100412828(ENTPD6)
MMU: 
100862375(Gm21685) 12497(Entpd6) 12499(Entpd5) 67464(Entpd4) 76025(Cant1)
RNO: 
246272(Cant1) 314312(Entpd5) 361063(Entpd4) 85260(Entpd6)
CGE: 
100751454(Entpd5) 100765414(Entpd6) 100767250(Cant1) 100771637(Entpd4)
NGI: 
103747295(Cant1) 103747371(Entpd5) 103748013(Entpd4) 103748530(Entpd6)
HGL: 
101700645(Entpd4) 101703881(Entpd5) 101708374(Cant1) 101717001(Entpd6)
OCU: 
100341814(ENTPD5) 100342665(ENTPD6) 100345399(ENTPD4) 100352568(CANT1)
TUP: 
102473435(ENTPD5) 102477259(ENTPD6) 102482611(CANT1) 102499936(ENTPD4)
CFA: 
480384(ENTPD5) 485564(ENTPD6) 486117(ENTPD4)
AML: 
UMR: 
103671253(ENTPD5) 103681915(ENTPD6)
FCA: 
101085117(ENTPD4) 101090270(ENTPD5) 101090852(ENTPD6)
PTG: 
102952970(ENTPD4) 102958703(ENTPD5) 102966424(ENTPD6) 102968784(CANT1)
BTA: 
508097(ENTPD6) 518086(CANT1) 531411(ENTPD4) 533096(ENTPD5)
BOM: 
102264690(ENTPD6) 102272160(CANT1) 102277970 102278224(ENTPD5) 102283172(ENTPD4)
PHD: 
102316077(ENTPD6) 102317546(CANT1) 102321161(ENTPD4) 102323649(ENTPD5)
CHX: 
102174488(ENTPD6) 102177094(CANT1) 102177626(ENTPD4) 102187956(ENTPD5)
OAS: 
101104845(ENTPD6) 101105824(ENTPD5) 101120555(ENTPD4) 101122609(CANT1)
SSC: 
100154506(ENTPD5) 100155254(ENTPD4) 100620107(CANT1) 100626131(ENTPD6)
CFR: 
102506563(ENTPD4) 102507072 102513093(ENTPD6) 102521166(CANT1) 102524265(ENTPD5)
BACU: 
103001237(ENTPD4) 103008563(ENTPD5) 103016453(CANT1) 103017331(ENTPD6)
LVE: 
103069753(CANT1) 103072735(ENTPD6) 103076010(ENTPD5) 103090675(ENTPD4)
ECB: 
100053982(ENTPD4) 100056466(ENTPD5) 100057043(ENTPD6) 100057405(CANT1)
MYB: 
102243929(ENTPD6) 102251396(CANT1) 102251399(ENTPD4) 102262670(ENTPD5)
MYD: 
102756459(ENTPD5) 102761731(ENTPD6) 102767239(ENTPD4) 102768384(CANT1)
PALE: 
102879280(ENTPD6) 102879747(ENTPD4) 102885970(ENTPD5) 102886824(CANT1)
MDO: 
100021277(ENTPD4) 100024118(ENTPD5) 100026552(CANT1) 100033226(ENTPD6)
SHR: 
100914260(ENTPD4) 100925749 100934101(CANT1) 100934821(ENTPD5) 100935093(ENTPD6)
OAA: 
GGA: 
416708(ENTPD6) 419531(ENTPD4) 423343(ENTPD5) 430103(CANT1)
MGP: 
APLA: 
101790396(CANT1) 101794207(ENTPD5) 101795352(ENTPD4) 101798772(ENTPD6)
TGU: 
100219260(CANT1) 100220000(ENTPD5) 100224923(ENTPD6)
FAB: 
101811604(CANT1) 101814014(ENTPD6) 101814697(ENTPD4) 101820141(ENTPD5)
PHI: 
102101855(ENTPD4) 102106545(ENTPD5) 102108288(CANT1) 102109632(ENTPD6)
FPG: 
101910519(ENTPD4) 101911075(ENTPD5) 101912651(CANT1) 101920667(ENTPD6)
FCH: 
102047237(ENTPD6) 102056974(ENTPD5) 102057968(CANT1) 102058083(ENTPD4)
CLV: 
102084705(ENTPD5) 102084729(CANT1) 102092438(ENTPD4) 102095170(ENTPD6)
ASN: 
102377226(ENTPD5) 102382407(ENTPD4) 102384786(ENTPD6) 102387737(CANT1)
AMJ: 
102558177(ENTPD5) 102558389(ENTPD4) 102558883(CANT1) 102561141(ENTPD6)
PSS: 
102446197(ENTPD5) 102448778(ENTPD6) 102457836(ENTPD4) 102457946
CMY: 
102933100(ENTPD6) 102944019(ENTPD4) 102944229(ENTPD5) 102947400(CANT1)
ACS: 
100555642(entpd5) 100561218(entpd6) 100562980(entpd4) 100563392(cant1) 103282882
PBI: 
103048410(ENTPD6) 103051878(CANT1) 103054355(ENTPD5) 103056945(ENTPD4)
XLA: 
379060(cant1) 495422(entpd4) 734187(entpd6)
XTR: 
394537(cant1) 677731(entpd4) 677734(entpd5) 677735(entpd6)
DRE: 
406558(cant1a) 436692(entpd4) 445201(cant1b) 550560(entpd6) 556849(entpd5a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102345277(CANT1) 102354256(ENTPD6) 102364599(ENTPD4) 102364924(ENTPD5)
CMK: 
103175547(cant1) 103179204(entpd6) 103186794(entpd5) 103188915(entpd7) 103191300
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
550987(GB18870) 551373
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG11542(Cbr-uda-1) CBG14198 CBG14784(Cbr-mig-23) CBG16731
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CME: 
GSL: 
CCP: 
MBR: 
EHI: 
EHI_053610(59.t00033) EHI_104590(415.t00008) EHI_112890(17.t00006)
EDI: 
ACAN: 
CPV: 
CHO: 
TGO: 
PTI: 
TPS: 
PIF: 
EHX: 
TBR: 
Tb927.7.1930(Tb07.43M14.370)
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
PSTT: 
 » show all
Taxonomy
Reference
1  [PMID:14389272]
  Authors
GIBSON DM, AYENGAR P, SANADI DR.
  Title
A phosphatase specific for nucleoside diphosphates.
  Journal
Biochim. Biophys. Acta. 16 (1955) 536-8.
Reference
2
  Authors
Horecker, B.L., Hurwitz, J. and Heppel, L.A.
  Title
The synthesis of ribose 5-pyrophosphate and ribose 5-triphosphate.
  Journal
J. Am. Chem. Soc. 79 (1957) 701-702.
Reference
3  [PMID:11041856]
  Authors
Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE
  Title
CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart.
  Journal
Biochemistry. 39 (2000) 12916-23.
  Sequence
[hsa:955]
Reference
4  [PMID:12167635]
  Authors
Failer BU, Braun N, Zimmermann H
  Title
Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase.
  Journal
J. Biol. Chem. 277 (2002) 36978-86.
  Sequence
[hsa:124583] [rno:246272]
Reference
5  [PMID:15102851]
  Authors
Uccelletti D, O'Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB
  Title
ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase  from Caenorhabditis elegans.
  Journal
J. Biol. Chem. 279 (2004) 27390-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-69-4

DBGET integrated database retrieval system