KEGG   ENZYME: 3.6.1.61Help
Entry
EC 3.6.1.61                 Enzyme                                 

Name
diadenosine hexaphosphate hydrolase (ATP-forming);
Ndx1
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)
Reaction(IUBMB)
(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = 2 ATP [RN:R09879];
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = ATP + ADP [RN:R09880];
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP [RN:R00184]
Reaction(KEGG)
Substrate
P1,P6-bis(5'-adenosyl)hexaphosphate [CPD:C20190];
H2O [CPD:C00001];
P1,P5-bis(5'-adenosyl)pentaphosphate;
P1,P4-bis(5'-adenosyl)tetraphosphate
Product
ATP [CPD:C00002];
ADP [CPD:C00008];
AMP [CPD:C00020]
Comment
The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5-guanosyl) tetraphosphate very slowly [cf. EC 3.6.1.17, bis(5-nucleosyl)-tetraphosphatase (asymmetrical)].
History
EC 3.6.1.61 created 2012
Reference
1  [PMID:15024014]
  Authors
Iwai T, Kuramitsu S, Masui R
  Title
The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity.
  Journal
J. Biol. Chem. 279 (2004) 21732-9.
  Organism
Thermus thermophilus
  Sequence
[ttj:TTHA1880]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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