KEGG   ENZYME: 3.6.1.62Help
Entry
EC 3.6.1.62                 Enzyme                                 
Name
m7GpppN-mRNA hydrolase;
Dcp2;
NUDT16;
D10 protein;
D9 protein;
D10 decapping enzyme;
decapping enzyme
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
m7GpppN-mRNA m7GDP phosphohydrolase
Reaction(IUBMB)
m7G5'ppp5'-mRNA + H2O = m7GDP + 5'-phospho-mRNA
Substrate
m7G5'ppp5'-mRNA;
H2O [CPD:C00001]
Product
m7GDP;
5'-phospho-mRNA
Comment
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ [5].
Orthology
K12613  
mRNA-decapping enzyme subunit 2
K16855  
U8 snoRNA-decapping enzyme
Genes
HSA: 
131870(NUDT16) 167227(DCP2)
PTR: 
101059329 460696(NUDT16) 462001(DCP2)
PPS: 
GGO: 
101141130(DCP2) 101147310(NUDT16)
PON: 
MCC: 
694225(DCP2) 717914(NUDT16) 717946
MMU: 
70640(Dcp2) 73532(1700080E11Rik) 75686(Nudt16)
RNO: 
291604(Dcp2) 363129(Nudt16) 688828
CFA: 
489086(DCP2) 610721(NUDT16)
AML: 
FCA: 
101094947(NUDT16) 101097375(DCP2)
BTA: 
512320(NUDT16) 539770(DCP2)
SSC: 
100152693 100516785(DCP2)
ECB: 
100064676 100073182(DCP2)
MDO: 
100015769(DCP2) 100029401
SHR: 
100921288 100922624(DCP2)
OAA: 
100075661(DCP2)
GGA: 
769972(DCP2)
TGU: 
100190266 100223050(DCP2)
ACS: 
100561966(dcp2) 100563390
XLA: 
414677(nudt16) 606489(dcp2)
XTR: 
100327255(nudt16) 549617(dcp2)
DRE: 
100534816 100534849 393121(dcp2) 449987
TRU: 
101067770 101075218
OLA: 
101159655 101171079
BFO: 
BRAFLDRAFT_57615 BRAFLDRAFT_98536
CIN: 
100175348 100177159 100185451
SPU: 
581337
DME: 
Dmel_CG6169(Dcp2)
DPO: 
Dpse_GA19405
DAN: 
Dana_GF10373
DER: 
Dere_GG13519
DPE: 
Dper_GL24929
DSE: 
Dsec_GM24463
DSI: 
Dsim_GD12535
DWI: 
Dwil_GK20641
DYA: 
Dyak_GE22821
DGR: 
Dgri_GH14473
DMO: 
Dmoj_GI13619
DVI: 
Dvir_GJ13955
AGA: 
AgaP_AGAP011114
AAG: 
AaeL_AAEL000783 AaeL_AAEL015607
CQU: 
CpipJ_CPIJ012496 CpipJ_CPIJ019463
AME: 
412521(Dcp2)
NVI: 
100123522(NV10255)
TCA: 
656834
API: 
100162814 100166838
PHU: 
Phum_PHUM040630 Phum_PHUM040640 Phum_PHUM243220
ISC: 
IscW_ISCW015751
CEL: 
CELE_F52G2.1(dcap-2)
CBR: 
CBG01756(Cbr-dcap-2)
BMY: 
Bm1_26285
TSP: 
Tsp_04018
SMM: 
Smp_006190
NVE: 
NEMVE_v1g236687
HMG: 
100200480 100204487
TAD: 
TRIADDRAFT_22739
AQU: 
100632565 100632976
ATH: 
AT5G13570(DCP2)
ALY: 
ARALYDRAFT_488176
GMX: 
100807659
CSV: 
101205224 101222952 101228469 101230189
RCU: 
RCOM_0026480
POP: 
POPTR_563741 POPTR_833858
VVI: 
100249543
OSA: 
4331069
DOSA: 
Os02t0805900-01(Os02g0805900)
SBI: 
SORBI_10g028040(SORBIDRAFT_10g028040)
ZMA: 
100283962
SMO: 
SELMODRAFT_427515
PPP: 
PHYPADRAFT_124756 PHYPADRAFT_126386 PHYPADRAFT_152241
CRE: 
CHLREDRAFT_146010(DCP2)
VCN: 
VOLCADRAFT_90679
OLU: 
OSTLU_5662
OTA: 
Ot08g02610
CME: 
CMJ226C
SCE: 
YNL118C(DCP2)
AGO: 
AGOS_ACR270W
ERC: 
Ecym_8207
KLA: 
KLLA0F23980g
LTH: 
KLTH0B05104g
PPA: 
PAS_chr4_0194
VPO: 
Kpol_1048p23
ZRO: 
ZYRO0B16324g
CGR: 
CAGL0L04004g
NCS: 
NCAS_0G02500(NCAS0G02500)
NDI: 
NDAI_0F02790(NDAI0F02790)
TPF: 
TPHA_0I01530(TPHA0I01530)
TBL: 
TBLA_0C05550(TBLA0C05550)
TDL: 
TDEL_0B05170(TDEL0B05170)
KAF: 
KAFR_0J02070(KAFR0J02070)
DHA: 
DEHA2A11110g
PIC: 
PICST_68309
PGU: 
PGUG_01953
LEL: 
LELG_03102
CAL: 
CaO19.13730(DCP2) CaO19.6373(DCP2)
CTP: 
CTRG_03105
CDU: 
CD36_33760
COT: 
CORT_0D05760
YLI: 
YALI0C13310g
CLU: 
CLUG_02825
NCR: 
NCU07889
SMP: 
SMAC_02163
PAN: 
PODANSg5515
TTT: 
THITE_2120251
MTM: 
MYCTH_2303547
MGR: 
MGG_06410
FGR: 
FG05411.1
NHE: 
NECHADRAFT_47056
VAL: 
VDBG_06994
SSL: 
SS1G_03492
BFU: 
BC1G_12693
ANI: 
AN0060.2
NFI: 
NFIA_074780
AFM: 
AFUA_5G12420
AOR: 
AOR_1_644094(AO090120000363)
ANG: 
ANI_1_1634124(An14g06800)
AFV: 
AFLA_093470
ACT: 
ACLA_015480
PCS: 
Pc21g07650
CIM: 
CIMG_09326
CPW: 
CPC735_017120
PBL: 
PAAG_02506
URE: 
UREG_04975
ABE: 
ARB_03404
TVE: 
TRV_08090
PNO: 
SNOG_10297
PTE: 
PTT_19311
ZTR: 
MYCGRDRAFT_49141
TML: 
GSTUM_00010106001
SPO: 
SPAC19A8.12(dcp2)
CNE: 
CNK00240
CNB: 
CNBK3180
CGI: 
CGB_K4260W
PPL: 
POSPLDRAFT_126230
LBC: 
LACBIDRAFT_300645
CCI: 
CC1G_11296
SCM: 
SCHCODRAFT_64476
UMA: 
UM00960.1
MGL: 
MGL_1038
PGR: 
PGTG_03310
ECU: 
ECU07_1630
EIN: 
Eint_071600
EHE: 
EHEL_071610
NCE: 
NCER_101656
NGR: 
NAEGRDRAFT_2668 NAEGRDRAFT_80596
DDI: 
DDB_G0283315(dcp2)
DPP: 
DICPUDRAFT_46996
EHI: 
EHI_058810(230.t00023) EHI_098250(77.t00025)
EDI: 
EDI_161960 EDI_281690
PFA: 
PF13_0048
PFD: 
PFDG_04191
PFH: 
PFHG_03735
PYO: 
PY07320
PCB: 
PC302629.00.0
PBE: 
PB000662.03.0
PKN: 
PKH_140780
PVX: 
PVX_122275
PCY: 
PCYB_141840
TAN: 
TA02540
TPV: 
TP03_0049
BBO: 
BBOV_III003580(17.m07337)
CPV: 
cgd7_2710
CHO: 
Chro.70307
TGO: 
TGME49_027450
TET: 
TTHERM_00825680
PTM: 
GSPATT00036590001
TVA: 
TVAG_198330
PTI: 
PHATRDRAFT_46543
TPS: 
THAPSDRAFT_22284
PIF: 
PITG_03118
 » show all
Taxonomy
Reference
1  [PMID:17158604]
  Authors
Xu J, Yang JY, Niu QW, Chua NH
  Title
Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development.
  Journal
Plant. Cell. 18 (2006) 3386-98.
Reference
2  [PMID:21337011]
  Authors
Lu G, Zhang J, Li Y, Li Z, Zhang N, Xu X, Wang T, Guan Z, Gao GF, Yan J
  Title
hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA.
  Journal
Protein. Cell. 2 (2011) 64-73.
Reference
3  [PMID:12486012]
  Authors
van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Seraphin B
  Title
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.
  Journal
EMBO. J. 21 (2002) 6915-24.
Reference
4  [PMID:17283339]
  Authors
Parrish S, Resch W, Moss B
  Title
Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 2139-44.
Reference
5  [PMID:19210265]
  Authors
Souliere MF, Perreault JP, Bisaillon M
  Title
Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism.
  Journal
Biochem. J. 420 (2009) 27-35.
Reference
6  [PMID:17881455]
  Authors
Parrish S, Moss B
  Title
Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses.
  Journal
J. Virol. 81 (2007) 12973-8.
Reference
7  [PMID:21070968]
  Authors
Song MG, Li Y, Kiledjian M
  Title
Multiple mRNA decapping enzymes in mammalian cells.
  Journal
Mol. Cell. 40 (2010) 423-32.
Other DBs
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