KEGG   ENZYME: 3.6.1.64Help
Entry
EC 3.6.1.64                 Enzyme                                 

Name
inosine diphosphate phosphatase;
(deoxy)inosine diphosphatase;
NUDT16
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
inosine diphosphate phosphatase
Reaction(IUBMB)
(1) IDP + H2O = IMP + phosphate [RN:R00961];
(2) dIDP + H2O = dIMP + phosphate [RN:R10235]
Reaction(KEGG)
Substrate
IDP [CPD:C00104];
H2O [CPD:C00001];
dIDP [CPD:C01344]
Product
IMP [CPD:C00130];
phosphate [CPD:C00009];
dIMP [CPD:C06196]
Comment
The human enzyme also hydrolyses GDP and dGDP, and to a lesser extent ITP, dITP and XTP.
History
EC 3.6.1.64 created 2013
Pathway
Purine metabolism
Orthology
K16855  
U8 snoRNA-decapping enzyme
Genes
HSA: 
131870(NUDT16)
PTR: 
460696(NUDT16)
PPS: 
100972453(NUDT16)
GGO: 
101147310(NUDT16)
PON: 
NLE: 
100607601(NUDT16)
MCC: 
717914(NUDT16) 717946
MCF: 
CSAB: 
RRO: 
104675668(NUDT16)
CJC: 
SBQ: 
MMU: 
73532(1700080E11Rik) 75686(Nudt16)
RNO: 
363129(Nudt16) 688828
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
102479774(NUDT16)
CFA: 
610721(NUDT16)
AML: 
100482941(NUDT16)
FCA: 
101094947(NUDT16)
PTG: 
102951403(NUDT16)
BTA: 
512320(NUDT16)
BOM: 
102264435(NUDT16)
PHD: 
102318311(NUDT16)
CHX: 
102175719(NUDT16)
OAS: 
654329(NUDT16)
SSC: 
CFR: 
BACU: 
103000667(NUDT16)
LVE: 
103090159(NUDT16)
ECB: 
100064676(NUDT16)
MYB: 
102252289(NUDT16)
MYD: 
102769718(NUDT16)
PALE: 
102891676(NUDT16)
LAV: 
100666216(NUDT16)
MDO: 
100029401(NUDT16)
SHR: 
MGP: 
CJO: 
TGU: 
100190266(NUDT16L1)
ASN: 
ACS: 
100563390(nudt16)
PBI: 
GJA: 
XLA: 
414677(nudt16)
XTR: 
100327255(nudt16)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
BFO: 
CIN: 
API: 
PHU: 
HRO: 
LGI: 
OBI: 
NVE: 
ADF: 
HMG: 
AQU: 
SULR: 
 » show all
Taxonomy
Reference
1  [PMID:20385596]
  Authors
Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y
  Title
NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.
  Journal
Nucleic. Acids. Res. 38 (2010) 4834-43.
  Sequence
[hsa:131870] [mmu:75686]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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