KEGG   ENZYME: 3.6.3.37Help
Entry
EC 3.6.3.37                 Enzyme                                 

Name
guanine-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (guanine-importing)
Reaction(IUBMB)
ATP + H2O + guanineout = ADP + phosphate + guaninein [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
guanine [CPD:C00242]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
guanine [CPD:C00242]
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A eukaryotic enzyme that imports guanine and tryptophan (it contains a single ATP-binding site).
History
EC 3.6.3.37 created 2000
Reference
1  [PMID:3149712]
  Authors
Dreesen TD, Johnson DH, Henikoff S.
  Title
The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes.
  Journal
Mol. Cell. Biol. 8 (1988) 5206-15.
Reference
2  [PMID:2503416]
  Authors
Tearle RG, Belote JM, McKeown M, Baker BS, Howells AJ.
  Title
Cloning and characterization of the scarlet gene of Drosophila melanogaster.
  Journal
Genetics. 122 (1989) 595-606.
Reference
3
  Authors
Griffiths, J.K. and Sansom, C.E.
  Title
The Transporter Factsbook, Academic Press, San Diego, 1998.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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