KEGG   ENZYME: 3.6.3.46Help
Entry
EC 3.6.3.46                 Enzyme                                 

Name
cadmium-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (heavy-metal-exporting)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports some heavy metals, especially Cd2+, from the cytosol into the vacuole.
History
EC 3.6.3.46 created 2000
Reference
1  [PMID:8626454]
  Authors
Li ZS, Szczypka M, Lu YP, Thiele DJ, Rea PA.
  Title
The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump.
  Journal
J. Biol. Chem. 271 (1996) 6509-17.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
2  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv. Microb. Physiol. 40 (1998) 81-136.
  Organism
bacteria
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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