fatty-acyl-CoA-transporting ATPase

Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances

ATP phosphohydrolase (fatty-acyl-CoA-transporting)

ATP + H2O + fatty acyl CoAcis = ADP + phosphate + fatty acyl CoAtrans [RN:R00086]

R00086

ATP [CPD:C00002];
H2O [CPD:C00001];
fatty acyl CoAcis

ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome.

1  [PMID:1968461]

Kamijo K, Taketani S, Yokota S, Osumi T, Hashimoto T.

The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily.

J. Biol. Chem. 265 (1990) 4534-40.

Rattus norvegicus [GN:rno]

2  [PMID:8670886]

Hettema EH, van Roermund CW, Distel B, van den Berg M, Vilela C, Rodrigues-Pousada C, Wanders RJ, Tabak HF.

The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.

EMBO. J. 15 (1996) 3813-22.

Saccharomyces cerevisiae [GN:sce]

3  [PMID:9889977]

Saier MH Jr.

Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.

Adv. Microb. Physiol. 40 (1998) 81-136.

bacteria