KEGG   ENZYME: 3.6.3.47Help
Entry
EC 3.6.3.47                 Enzyme                                 

Name
fatty-acyl-CoA-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (fatty-acyl-CoA-transporting)
Reaction(IUBMB)
ATP + H2O + fatty acyl CoAcis = ADP + phosphate + fatty acyl CoAtrans [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
fatty acyl CoAcis
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
fatty acyl CoAtrans
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome.
History
EC 3.6.3.47 created 2000
Reference
1  [PMID:1968461]
  Authors
Kamijo K, Taketani S, Yokota S, Osumi T, Hashimoto T.
  Title
The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily.
  Journal
J. Biol. Chem. 265 (1990) 4534-40.
Reference
2  [PMID:8670886]
  Authors
Hettema EH, van Roermund CW, Distel B, van den Berg M, Vilela C, Rodrigues-Pousada C, Wanders RJ, Tabak HF.
  Title
The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.
  Journal
EMBO. J. 15 (1996) 3813-22.
Reference
3  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv. Microb. Physiol. 40 (1998) 81-136.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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