KEGG   ENZYME: 3.6.3.50Help
Entry
EC 3.6.3.50                 Enzyme                                 

Name
protein-secreting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (protein-secreting)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. There are several families of enzymes included here, e.g. ATP-hydrolysing enzymes of the general secretory pathway (Sec or Type II), of the virulence-related secretory pathway (Type III) and of the conjugal DNA-protein transfer pathway (Type IV). Type II enzymes occur in bacteria, archaea and eucarya, whereas type III and type IV enzymes occur in bacteria where they form components of a multi-subunit complex.
History
EC 3.6.3.50 created 2000
Reference
1  [PMID:8022262]
  Authors
Saier MH Jr, Tam R, Reizer A, Reizer J.
  Title
Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport.
  Journal
Mol. Microbiol. 11 (1994) 841-7.
  Organism
Homo sapiens, Alcaligenes eutrophus, Sinorhizobium meliloti
Reference
2  [PMID:8969244]
  Authors
Mecsas JJ, Strauss EJ.
  Title
Molecular mechanisms of bacterial virulence: type III secretion and pathogenicity islands.
  Journal
Emerg. Infect. Dis. 2 (1996) 270-88.
  Organism
Escherichia coli, Yersinia spp., S. typhimurium, Salmonella spp.
Reference
3  [PMID:9084158]
  Authors
Thomas JD, Reeves PJ, Salmond GP.
  Title
The general secretion pathway of Erwinia carotovora subsp. carotovora: analysis of the membrane topology of OutC and OutF.
  Journal
Microbiology. 143 ( Pt 3) (1997) 713-20.
  Organism
Erwinia carotovora
Reference
4  [PMID:9115193]
  Authors
Baker B, Zambryski P, Staskawicz B, Dinesh-Kumar SP.
  Title
Signaling in plant-microbe interactions.
  Journal
Science. 276 (1997) 726-33.
  Organism
Escherichia coli
Reference
5  [PMID:9680212]
  Authors
Martinez A, Ostrovsky P, Nunn DN.
  Title
Identification of an additional member of the secretin superfamily of proteins in Pseudomonas aeruginosa that is able to function in type II protein secretion.
  Journal
Mol. Microbiol. 28 (1998) 1235-46.
  Organism
Pseudomonas aeruginosa
Reference
6  [PMID:10085046]
  Authors
Schuch R, Maurelli AT.
  Title
The mxi-Spa type III secretory pathway of Shigella flexneri requires an outer membrane lipoprotein, MxiM, for invasin translocation.
  Journal
Infect. Immun. 67 (1999) 1982-91.
  Organism
Shigella flexneri
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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