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Entry
EC 3.6.3.6                  Enzyme                                 

Name
H+-exporting ATPase;
proton-translocating ATPase;
yeast plasma membrane H+-ATPase;
yeast plasma membrane ATPase;
ATP phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (H+-exporting)
Reaction(IUBMB)
ATP + H2O + H+in = ADP + phosphate + H+out [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
H+ [CPD:C00080]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
H+ [CPD:C00080]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane.
History
EC 3.6.3.6 created 1984 as EC 3.6.1.35, transferred 2000 to EC 3.6.3.6
Pathway
Oxidative phosphorylation
Orthology
K01535  
H+-transporting ATPase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0001s14700g(POPTRDRAFT_178875) POPTR_0001s16150g POPTR_0003s07840g(POPTRDRAFT_757063) POPTR_0003s17820g(POPTRDRAFT_554857) POPTR_0005s21150g(POPTRDRAFT_204832) POPTR_0006s00770g(POPTRDRAFT_801678) POPTR_0006s17960g POPTR_0006s20290g(POPTRDRAFT_762873) POPTR_0006s28990g POPTR_0012s07350g(POPTRDRAFT_422528) POPTR_0014s04570g POPTR_0015s07710g(POPTRDRAFT_251766) POPTR_0018s03700g(POPTRDRAFT_737523) POPTR_0018s09750g(POPTRDRAFT_578576) POPTR_0018s12040g(POPTRDRAFT_779609)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0797300-01(Os02g0797300) Os03t0100800-01(Os03g0100800) Os03t0183900-01(Os03g0183900) Os03t0689300-01(Os03g0689300) Os04t0656100-01(Os04g0656100) Os05t0319800-01(Os05g0319800) Os06t0181500-01(Os06g0181500) Os07t0191200-01(Os07g0191200) Os12t0638700-01(Os12g0638700)
OBR: 
BDI: 
SBI: 
SORBI_01g011610(SORBIDRAFT_01g011610) SORBI_01g045000(SORBIDRAFT_01g045000) SORBI_01g048440(SORBIDRAFT_01g048440) SORBI_01g050166(SORBIDRAFT_01g050166) SORBI_01g050620(SORBIDRAFT_01g050620) SORBI_02g005440(SORBIDRAFT_02g005440) SORBI_03g046720(SORBIDRAFT_03g046720) SORBI_04g036040(SORBIDRAFT_04g036040) SORBI_06g031240(SORBIDRAFT_06g031240) SORBI_07g007610(SORBIDRAFT_07g007610) SORBI_08g005155(SORBIDRAFT_08g005155) SORBI_08g023070(SORBIDRAFT_08g023070) SORBI_10g005500(SORBIDRAFT_10g005500) SORBI_10g025470(SORBIDRAFT_10g025470)
ZMA: 
100216710(pco106203) 100383137 100383411(si687062f01(361)) 100383904 100501185 100502231 542303(mha1) 542439(mha2)
SITA: 
ATR: 
s00002p00260210(AMTR_s00002p00260210) s00019p00234460(AMTR_s00019p00234460) s00026p00031590(AMTR_s00026p00031590) s00026p00031910(AMTR_s00026p00031910) s00026p00033380(AMTR_s00026p00033380) s00111p00107570(AMTR_s00111p00107570) s00131p00073280(AMTR_s00131p00073280) s00417p00000990(AMTR_s00417p00000990)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
SCE: 
YGL008C(PMA1) YPL036W(PMA2)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A06540(NCAS0A06540) NCAS_0B05420(NCAS0B05420)
NDI: 
NDAI_0B02650(NDAI0B02650) NDAI_0D03520(NDAI0D03520)
TPF: 
TPHA_0K01590(TPHA0K01590)
TBL: 
TBLA_0A09050(TBLA0A09050) TBLA_0C04030(TBLA0C04030)
TDL: 
TDEL_0F02310(TDEL0F02310)
KAF: 
KAFR_0F03370(KAFR0F03370) KAFR_0F03380(KAFR0F03380)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
TRE: 
VAL: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_1478174(AO090005000842) AOR_1_706084(AO090020000403) AOR_1_932134(AO090102000565)
ANG: 
ANI_1_1818144(An16g05840) ANI_1_758084(An09g05950)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
DDI: 
DPP: 
DFA: 
DFA_05287(patB)
ACAN: 
TGO: 
PTI: 
PHATRDRAFT_12452(ATPase-3A) PHATRDRAFT_55200(ATPase2-3A)
TPS: 
PIF: 
NGD: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
MMT: 
HNA: 
AFE: 
AFR: 
ACU: 
AFI: 
BXE: 
PPK: 
PPNO: 
PRB: 
BAV: 
TIN: 
THI: 
SLT: 
SUA: 
NSA: 
NIS: 
SUN: 
NAM: 
GSK: 
GME: 
DDN: 
DPS: 
DAO: 
DTI: 
HMR: 
MSC: 
PSF: 
NPP: 
GOH: 
ACR: 
AMV: 
RRU: 
RRF: 
LCA: 
LCB: 
LCZ: 
LCS: 
LCE: 
LCW: 
LCL: 
LKE: 
LPI: 
LPQ: 
AWO: 
MMI: 
MCB: 
MLI: 
MKN: 
RHA: 
AFO: 
SNG: 
GMA: 
CYT: 
CAN: 
CPC: 
IAL: 
ATM: 
OPR: 
HHO: 
HYS: 
TAM: 
CEX: 
LFC: 
MJA: 
MFE: 
MVU: 
MFS: 
MAE: 
MOK: 
MAC: 
MBA: 
MBU: 
MBG: 
MTH: 
MEL: 
MEW: 
METH: 
TAC: 
PTO: 
FAC: 
ABI: 
ACF: 
DMU: 
THG: 
SIS: 
SII: 
MSE: 
MCN: 
AHO: 
VMO: 
TPE: 
THB: 
FFO: 
KCR: 
 » show all
Taxonomy
Reference
1  [PMID:6461354]
  Authors
Goffeau A, Slayman CW.
  Title
The proton-translocating ATPase of the fungal plasma membrane.
  Journal
Biochim. Biophys. Acta. 639 (1981) 197-223.
Reference
2  [PMID:3005867]
  Authors
Serrano R, Kielland-Brandt MC, Fink GR.
  Title
Yeast plasma membrane ATPase is essential for growth and has homology with (Na+ + K+), K+- and Ca2+-ATPases.
  Journal
Nature. 319 (1986) 689-93.
  Organism
Saccharomyces cerevisiae
  Sequence
[sce:YGL008C]
Reference
3  [PMID:2144186]
  Authors
Serrano R, Portillo F.
  Title
Catalytic and regulatory sites of yeast plasma membrane H(+)-ATPase studied by directed mutagenesis.
  Journal
Biochim. Biophys. Acta. 1018 (1990) 195-9.
  Organism
Saccharomyces cerevisiae
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system