KEGG ENZYME: 3.6.3.6

ENZYME: 3.6.3.6

Entry

EC 3.6.3.6 Enzyme

Name

H+-exporting ATPase;
proton-translocating ATPase;
yeast plasma membrane H+-ATPase;
yeast plasma membrane ATPase;
ATP phosphohydrolase

Class

Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances

Sysname

ATP phosphohydrolase (H+-exporting)

Reaction(IUBMB)

ATP + H2O + H+in = ADP + phosphate + H+out [RN:R00086]

Reaction(KEGG)

R00086

Substrate

ATP [CPD:C00002];
H2O [CPD:C00001];
H+ [CPD:C00080]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
H+ [CPD:C00080]

Comment

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane.

Pathway

ec00190

Oxidative phosphorylation

Orthology

K01535

H+-transporting ATPase

Genes

ATH:	AT1G17260(AHA10) AT1G80660(HA9) AT2G07560(HA6) AT2G18960(HA1) AT2G24520(HA5) AT3G42640(HA8) AT3G47950(HA4) AT3G60330(HA7) AT4G30190(HA2) AT5G57350(HA3) AT5G62670(HA11)
ALY:	ARALYDRAFT_323063 ARALYDRAFT_480836 ARALYDRAFT_919542
GMX:	100778065 100782329 100782459 100791692 100794372 100795836 100802859 100804422 100806187 100816905 100818043 100818997
MTR:	MTR_2g036650 MTR_3g108800 MTR_4g127710
CSV:	101211115 101212751 101213505 101214655 101214920 101217264 101221564 101221783 101224777
RCU:	RCOM_0006450 RCOM_0918380 RCOM_1513370 RCOM_1608600 RCOM_1643620
POP:	POPTR_178875 POPTR_251766 POPTR_422528 POPTR_554857 POPTR_578576 POPTR_591788 POPTR_737523 POPTR_743411 POPTR_757063 POPTR_762873 POPTR_779609 POPTR_801678 POPTR_826518 POPTR_828261
VVI:	100241576 100242786 100244257 100246127 100246249 100249749 100254244 100257762 100265284 100267065
OSA:	4331015 4331281 4331853 4333770 4337257 4338405 4340312 4342621 4352910
DOSA:	Os02t0797300-01(Os02g0797300) Os03t0100800-01(Os03g0100800) Os03t0689300-01(Os03g0689300) Os04t0656100-01(Os04g0656100) Os05t0319800-01(Os05g0319800) Os06t0181500-02(Os06g0181500) Os07t0191200-01(Os07g0191200) Os12t0638700-01(Os12g0638700)
BDI:	100823279 100828641 100830974 100831040 100841001 100844944 100846063 100846640
SBI:	SORBI_01g011610(SORBIDRAFT_01g011610) SORBI_01g048440(SORBIDRAFT_01g048440) SORBI_01g050620(SORBIDRAFT_01g050620) SORBI_02g005440(SORBIDRAFT_02g005440) SORBI_03g046720(SORBIDRAFT_03g046720) SORBI_04g036040(SORBIDRAFT_04g036040) SORBI_06g031240(SORBIDRAFT_06g031240) SORBI_07g007610(SORBIDRAFT_07g007610) SORBI_08g023070(SORBIDRAFT_08g023070) SORBI_10g005500(SORBIDRAFT_10g005500) SORBI_10g025470(SORBIDRAFT_10g025470)
ZMA:	100216710(pco106203) 100383137 100383904 100501185 542303(mha1) 542439(mha2)
SMO:	SELMODRAFT_419690 SELMODRAFT_76771 SELMODRAFT_83063
PPP:	PHYPADRAFT_153928
CRE:	CHLREDRAFT_182602(PMA2) CHLREDRAFT_38137 CHLREDRAFT_54949(PMH1)
VCN:	VOLCADRAFT_103448 VOLCADRAFT_105176
OLU:	OSTLU_41354
OTA:	Ot06g01560
CME:	CMQ247C
SCE:	YGL008C(PMA1) YPL036W(PMA2)
AGO:	AGOS_AGL085C
ERC:	Ecym_7237
KLA:	KLLA0A09031g
LTH:	KLTH0E07942g
PPA:	PAS_chr1-1_0002
VPO:	Kpol_1025p39
ZRO:	ZYRO0G10296g
CGR:	CAGL0A00495g
NCS:	NCAS_0A06540(NCAS0A06540)
NDI:	NDAI_0D03520(NDAI0D03520)
TPF:	TPHA_0K01590(TPHA0K01590)
TBL:	TBLA_0A09050(TBLA0A09050)
TDL:	TDEL_0F02310(TDEL0F02310)
KAF:	KAFR_0F03370(KAFR0F03370)
DHA:	DEHA2A08800g
PIC:	PICST_87366(PMA1)
PGU:	PGUG_02049
LEL:	LELG_02211
CAL:	CaO19.12838(PMA1) CaO19.5383(PMA1)
CTP:	CTRG_05722
CDU:	CD36_80660
COT:	CORT_0D06440
YLI:	YALI0B22066g
CLU:	CLUG_01338
NCR:	NCU01680
SMP:	SMAC_02399
PAN:	PODANSg6521
TTT:	THITE_2124446
MTM:	MYCTH_2312579
MGR:	MGG_04994 MGG_07200
FGR:	FG01425.1
NHE:	NECHADRAFT_77500 NECHADRAFT_98600
VAL:	VDBG_03037
SSL:	SS1G_03736 SS1G_13768
BFU:	BC1G_07014 BC1G_10137
ANI:	AN4859.2
NFI:	NFIA_022130 NFIA_038560 NFIA_069510
AFM:	AFUA_1G02480 AFUA_3G07640 AFUA_5G03550
AOR:	AOR_1_1478174(AO090005000842) AOR_1_706084(AO090020000403) AOR_1_932134(AO090102000565)
ANG:	ANI_1_1818144(An16g05840) ANI_1_758084(An09g05950)
AFV:	AFLA_006360 AFLA_080940 AFLA_100110
ACT:	ACLA_001620 ACLA_031880 ACLA_035600
PCS:	Pc15g01800 Pc21g15770 Pc22g21730 Pc24g02900
CIM:	CIMG_06288
CPW:	CPC735_028180
PBL:	PAAG_08082
URE:	UREG_04095
AJE:	HCAG_06977
PNO:	SNOG_01307 SNOG_01771
PTE:	PTT_03288 PTT_17271
ZTR:	MYCGRDRAFT_59052
TML:	GSTUM_00009331001
SPO:	SPAC1071.10c(pma1)
CNE:	CNG00380 CNN01260
CNB:	CNBG4400 CNBN1250
CGI:	CGB_G6340W CGB_N2030C
PPL:	POSPLDRAFT_29398
LBC:	LACBIDRAFT_191443 LACBIDRAFT_253028
CCI:	CC1G_03517 CC1G_15207
SCM:	SCHCODRAFT_86036
UMA:	UM02581.1
MGL:	MGL_2162
PGR:	PGTG_06276 PGTG_12495
DDI:	DDB_G0282817(patB)
DPP:	DICPUDRAFT_147817
TGO:	TGME49_052640 TGME49_084600
TBR:	Tb10.389.1170 Tb10.389.1180 Tb927.5.3400(Tb05.27M3.570)
TCR:	506649.20
LMA:	LMJF_18_1510(H1A-1) LMJF_18_1520(H1A-2)
LIF:	LINJ_18_1500(H1A-1) LINJ_18_1510(H1A-2)
LDO:	LDBPK_181510
LMI:	LMXM_18_1520
LBZ:	LBRM_18_1550
PTI:	PHATRDRAFT_12452(ATPase-3A) PHATRDRAFT_55200(ATPase2-3A)
TPS:	THAPS_7268
PIF:	PITG_00693
MMT:	Metme_3586
HNA:	Hneap_0971
AFE:	Lferr_0959 Lferr_2687
AFR:	AFE_0818 AFE_3086
ACU:	Atc_2720
AFI:	Acife_0797 Acife_3093
BXE:	Bxe_A3829 Bxe_B1515
BAV:	BAV3245
TIN:	Tint_1818
THI:	THI_2234 THI_2245
SLT:	Slit_0161
SUA:	Saut_1355
NSA:	Nitsa_0958 Nitsa_0960
NIS:	NIS_0930
SUN:	SUN_1289
NAM:	NAMH_0768
GSK:	KN400_2296
GME:	Gmet_3497
DDN:	DND132_1528
DPS:	DP0982
DAO:	Desac_1181
DTI:	Desti_1932
HMR:	Hipma_0132
MSC:	BN69_2442
PSF:	PSE_2034
NPP:	PP1Y_AT23059
GOH:	B932_1802
ACR:	Acry_3206
AMV:	ACMV_P2_00300
RRU:	Rru_A2263
RRF:	F11_11640
LCA:	LSEI_0125
LCB:	LCABL_01160
LCZ:	LCAZH_0133
LCS:	LCBD_0116
LCE:	LC2W_0106
LCW:	BN194_01190
AWO:	Awo_c04620 Awo_c27420
MMI:	MMAR_2578
MCB:	Mycch_1653 Mycch_3473
MLI:	MULP_02305
RHA:	RHA1_ro01842
AFO:	Afer_0291
SNG:	SNE_A12910
GMA:	AciX8_2808
CYT:	cce_0846
CAN:	Cyan10605_0858
CPC:	Cpar_0506
IAL:	IALB_0171
ATM:	ANT_07360
OPR:	Ocepr_1872
HHO:	HydHO_1357(kdpB)
HYS:	HydSN_1394
TAM:	Theam_0995
LFC:	LFE_1747
CEX:	CSE_01410
MJA:	MJ_1226
MFE:	Mefer_0580
MVU:	Metvu_0873
MFS:	MFS40622_0852
MAE:	Maeo_0802
MOK:	Metok_0504
MAC:	MA1678 MA2833
MBG:	BN140_2171
MTH:	MTH481 MTH482
MEL:	Metbo_1031
MEW:	MSWAN_1117 MSWAN_1175
TAC:	Ta1045
PTO:	PTO1482
ABI:	Aboo_1158
ACF:	AciM339_0846
DMU:	Desmu_0157
THG:	TCELL_1192
SIS:	LS215_0955
SII:	LD85_0717
MSE:	Msed_0505
MCN:	Mcup_1591
AHO:	Ahos_2125
VMO:	VMUT_0483
TPE:	Tpen_1427
FFO:	FFONT_0721
KCR:	Kcr_0389

» show all

Reference

1 [PMID:6461354]

Authors

Goffeau A, Slayman CW.

Title

The proton-translocating ATPase of the fungal plasma membrane.

Journal

Biochim. Biophys. Acta. 639 (1981) 197-223.

Reference

2 [PMID:3005867]

Authors

Serrano R, Kielland-Brandt MC, Fink GR.

Title

Yeast plasma membrane ATPase is essential for growth and has homology with (Na+ + K+), K+- and Ca2+-ATPases.

Journal

Nature. 319 (1986) 689-93.

Reference

3 [PMID:2144186]

Authors

Serrano R, Portillo F.

Title

Catalytic and regulatory sites of yeast plasma membrane H(+)-ATPase studied by directed mutagenesis.

Journal

Biochim. Biophys. Acta. 1018 (1990) 195-9.

Organism

Saccharomyces cerevisiae [GN:sce]

Other DBs

ExplorEnz - The Enzyme Database:

3.6.3.6

IUBMB Enzyme Nomenclature:

3.6.3.6

ExPASy - ENZYME nomenclature database:

3.6.3.6

BRENDA, the Enzyme Database:

3.6.3.6

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