KEGG   ENZYME: 3.6.3.7Help
Entry
EC 3.6.3.7                  Enzyme                                 

Name
Na+-exporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (Na+-exporting)
Reaction(IUBMB)
ATP + H2O + Na+in = ADP + phosphate + Na+out [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+ [CPD:C01330]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+ [CPD:C01330]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed.
History
EC 3.6.3.7 created 2000, modified 2001
Orthology
K01536  
Na+-exporting ATPase
Genes
SCE: 
YDR039C(ENA2)
CGR: 
AFM: 
Taxonomy
Reference
1  [PMID:7664728]
  Authors
Wieland J, Nitsche AM, Strayle J, Steiner H, Rudolph HK.
  Title
The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.
  Journal
EMBO. J. 14 (1995) 3870-82.
  Organism
Saccharomyces cerevisiae
  Sequence
Reference
2  [PMID:9224683]
  Authors
Catty P, de Kerchove d'Exaerde A, Goffeau A.
  Title
The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.
  Journal
FEBS. Lett. 409 (1997) 325-32.
  Organism
Saccharomyces cerevisiae
Reference
3  [PMID:9106203]
  Authors
Cheng J, Guffanti AA, Krulwich TA.
  Title
A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore.
  Journal
Mol. Microbiol. 23 (1997) 1107-20.
  Organism
Bacillus subtilis
Reference
4  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv. Microb. Physiol. 40 (1998) 81-136.
  Organism
bacteria
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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