KEGG   ENZYME: 3.6.4.2Help
Entry
EC 3.6.4.2                  Enzyme                                 
Name
dynein ATPase;
dynein adenosine 5'-triphosphatase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (tubulin-translocating)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa).
Reference
1  [PMID:5289252]
  Authors
Summers KE, Gibbons IR.
  Title
Adenosine triphosphate-induced sliding of tubules in trypsin-treated flagella of sea-urchin sperm.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 68 (1971) 3092-6.
  Organism
Tripneustes gratilla
Reference
2  [PMID:2972702]
  Authors
Gibbons IR.
  Title
Dynein ATPases as microtubule motors.
  Journal
J. Biol. Chem. 263 (1988) 15837-40.
Reference
3  [PMID:9760728]
  Authors
Gee M, Vallee R.
  Title
The role of the dynein stalk in cytoplasmic and flagellar motility.
  Journal
Eur. Biophys. J. 27 (1998) 466-73.
  Organism
Tetrahymena sp.
Other DBs
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