KEGG   ENZYME: 3.6.4.7Help
Entry
EC 3.6.4.7                  Enzyme                                 

Name
peroxisome-assembly ATPase;
peroxisome assembly factor-2
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (peroxisome-assembling)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
An extremely diversified group of enzymes that use the energy of ATP hydrolysis to import and assemble peroxisome components into the organelle. Their molecular masses range from 25 to 600 kDa.
History
EC 3.6.4.7 created 2000
Reference
1  [PMID:1441755]
  Authors
Lee YJ, Wickner RB.
  Title
AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases.
  Journal
Yeast. 8 (1992) 787-90.
  Organism
Saccharomyces cerevisiae
Reference
2  [PMID:7493019]
  Authors
Tsukamoto T, Miura S, Nakai T, Yokota S, Shimozawa N, Suzuki Y, Orii T, Fujiki Y, Sakai F, Bogaki A, et al.
  Title
Peroxisome assembly factor-2, a putative ATPase cloned by functional complementation on a peroxisome-deficient mammalian cell mutant.
  Journal
Nat. Genet. 11 (1995) 395-401.
  Organism
Rattus norvegicus
Reference
3  [PMID:8670792]
  Authors
Yahraus T, Braverman N, Dodt G, Kalish JE, Morrell JC, Moser HW, Valle D, Gould SJ.
  Title
The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor.
  Journal
EMBO. J. 15 (1996) 2914-23.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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