KEGG   ENZYME: 3.6.5.4Help
Entry
EC 3.6.5.4                  Enzyme                                 

Name
signal-recognition-particle GTPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on GTP to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
GTP phosphohydrolase (protein-synthesis-assisting)
Reaction(IUBMB)
GTP + H2O = GDP + phosphate [RN:R00335]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
H2O [CPD:C00001]
Product
GDP [CPD:C00035];
phosphate [CPD:C00009]
Comment
Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).
History
EC 3.6.5.4 created 2000 as EC 3.6.1.49, transferred 2003 to EC 3.6.5.4
Reference
1  [PMID:2541918]
  Authors
Connolly T, Gilmore R.
  Title
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide.
  Journal
Cell. 57 (1989) 599-610.
  Organism
Homo sapiens [GN:hsa], Canis familiaris [GN:cfa]
Reference
2  [PMID:1851576]
  Authors
Connolly T, Rapiejko PJ, Gilmore R.
  Title
Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor.
  Journal
Science. 252 (1991) 1171-3.
Reference
3  [PMID:8247130]
  Authors
Miller JD, Wilhelm H, Gierasch L, Gilmore R, Walter P.
  Title
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation.
  Journal
Nature. 366 (1993) 351-4.
  Organism
Escherichia coli [GN:eco]
Reference
4  [PMID:9002524]
  Authors
Freymann DM, Keenan RJ, Stroud RM, Walter P.
  Title
Structure of the conserved GTPase domain of the signal recognition particle.
  Journal
Nature. 385 (1997) 361-4.
  Organism
Thermus aquaticus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system