| Entry |
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| Name |
signal-recognition-particle GTPase
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| Class |
Hydrolases;
Acting on acid anhydrides;
Acting on GTP to facilitate cellular and subcellular movement
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| Sysname |
GTP phosphohydrolase (protein-synthesis-assisting)
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| Reaction(IUBMB) |
GTP + H2O = GDP + phosphate [RN: R00335]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).
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| Reference |
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| Authors |
Connolly T, Gilmore R. |
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| Title |
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide. |
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| Journal |
Cell. 57 (1989) 599-610. |
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| Organism |
Homo sapiens [GN: hsa], Canis familiaris [GN: cfa] |
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| Reference |
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| Authors |
Connolly T, Rapiejko PJ, Gilmore R. |
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| Title |
Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. |
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| Journal |
Science. 252 (1991) 1171-3. |
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| Reference |
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| Authors |
Miller JD, Wilhelm H, Gierasch L, Gilmore R, Walter P. |
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| Title |
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation. |
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| Journal |
Nature. 366 (1993) 351-4. |
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| Organism |
Escherichia coli [GN: eco] |
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| Reference |
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| Authors |
Freymann DM, Keenan RJ, Stroud RM, Walter P. |
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| Title |
Structure of the conserved GTPase domain of the signal recognition particle. |
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| Journal |
Nature. 385 (1997) 361-4. |
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| Organism |
Thermus aquaticus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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