KEGG   ENZYME: 3.6.5.5Help
Entry
EC 3.6.5.5                  Enzyme                                 
Name
dynamin GTPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on GTP to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
GTP phosphohydrolase (vesicle-releasing)
Reaction(IUBMB)
GTP + H2O = GDP + phosphate [RN:R00335]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
H2O [CPD:C00001]
Product
GDP [CPD:C00035];
phosphate [CPD:C00009]
Comment
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
Orthology
K01528  
dynamin GTPase
K17065  
dynamin 1-like protein
Genes
HSA: 
10059(DNM1L) 1759(DNM1) 1785(DNM2) 26052(DNM3)
PTR: 
455718(DNM2) 457514(DNM3) 464766(DNM1) 465266(DNM1L)
PPS: 
100967261(DNM3) 100972805(DNM1L) 100991525(DNM1)
GGO: 
101133474(DNM3) 101138473(DNM2) 101150167(DNM1L)
PON: 
100431942(DNM3) 100442734(DNM2) 100446863(DNM1) 100458461(DNM1L)
MCC: 
695388(DNM1L) 705300(DNM3) 713558(DNM2) 717697(DNM1)
MMU: 
103967(Dnm3) 13429(Dnm1) 13430(Dnm2) 74006(Dnm1l)
RNO: 
114114(Dnm1l) 140694(Dnm1) 171574(Dnm3) 25751(Dnm2)
CFA: 
477649(DNM1L) 484949(DNM2) 490341(DNM3) 491319(DNM1)
AML: 
FCA: 
101090983(DNM3) 101094189(DNM1L) 101100788(DNM2) 654421
BTA: 
506315(DNM3) 508794(DNM1) 511691(DNM2) 540892(DNM1L)
SSC: 
100153921(DNM1) 100622538 100624497(DNM1L)
ECB: 
100057627 100060156(DNM3) 100070034 100070282(DNM1)
MDO: 
100011387(DNM2) 100012623 100012742(DNM1L) 100015400(DNM3) 100022725
SHR: 
100925580(DNM2) 100928220(DNM1L)
OAA: 
100073406 100084335 100084643 100086764 100086937
GGA: 
417217(DNM1) 418132(DNM1L) 424389(DNM3)
MGP: 
100538944 100541339 100544930(DNM1)
TGU: 
100221801(DNM3) 100222436(DNM1) 100229161(DNM1L) 100231298
ACS: 
100556614(dnm1) 100560647(dnm1l) 100562272 100566729
XLA: 
100101298(dnm2) 379244(MGC53884) 379875(dnm1l)
XTR: 
100494576 448130(dnm1) 496487(dnm2)
DRE: 
100307098(dnm1a) 100333543(dnm1b) 393896(dnm1l) 406525(dnm2l) 559334(dnm2) 566871
TRU: 
101067287 101070659 101073902 101075619 101078013
OLA: 
101154874 101155909 101157793 101160650 101162128 101168415 101169210
BFO: 
BRAFLDRAFT_121263 BRAFLDRAFT_87747
CIN: 
100180573(dnm1l) 100184166
SPU: 
577217(dnm1l) 765161
DME: 
Dmel_CG18102(shi) Dmel_CG3210(Drp1)
DPO: 
Dpse_GA14792 Dpse_GA16678
DAN: 
Dana_GF20511 Dana_GF20595
DER: 
Dere_GG17928 Dere_GG24504
DPE: 
Dper_GL21454 Dper_GL26456
DSE: 
Dsec_GM16218 Dsec_GM18211 Dsec_GM22595
DSI: 
Dsim_GD17250(Dsim_shi) Dsim_GD22819
DWI: 
Dwil_GK24492 Dwil_GK25241
DYA: 
Dyak_GE15067 Dyak_GE17235
DGR: 
Dgri_GH10575 Dgri_GH12050
DMO: 
Dmoj_GI21715 Dmoj_GI23021
DVI: 
Dvir_GJ15580 Dvir_GJ23546
AGA: 
AgaP_AGAP003018 AgaP_AGAP008896
AAG: 
AaeL_AAEL007288 AaeL_AAEL009068
CQU: 
CpipJ_CPIJ012794 CpipJ_CPIJ013552
AME: 
411472(Drp1)
NVI: 
100120115(NV14582) 100124244(NV10535)
TCA: 
657469 660635
API: 
100166793 100168088(Dnm1)
PHU: 
Phum_PHUM080460 Phum_PHUM479450
ISC: 
IscW_ISCW005274 IscW_ISCW018476
CEL: 
CELE_C02C6.1(dyn-1) CELE_T12E12.4(drp-1)
CBR: 
CBG07725(Cbr-dyn-1) CBG19923(Cbr-drp-1)
BMY: 
Bm1_01485 Bm1_31610
TSP: 
Tsp_06787 Tsp_08373
SMM: 
Smp_044920 Smp_067280
NVE: 
NEMVE_v1g174867 NEMVE_v1g191557
HMG: 
100199205(dnm1) 100215691
TAD: 
TRIADDRAFT_20368 TRIADDRAFT_53484
AQU: 
100632064 100638088
ATH: 
AT1G10290(ADL6) AT1G59610(DL3) AT2G14120(DRP3B) AT4G33650(DRP3A)
ALY: 
ARALYDRAFT_471140 ARALYDRAFT_475352 ARALYDRAFT_480333 ARALYDRAFT_491315
GMX: 
100778966 100785014 100795026 100798346 100807752 100809385 100820294
MTR: 
MTR_2g009690 MTR_4g022340 MTR_4g030140 MTR_4g093750
CSV: 
101208055 101215383 101220030 101220753 101230472
RCU: 
RCOM_0449340 RCOM_0497350 RCOM_1044670
POP: 
POPTR_1082232 POPTR_571595 POPTR_583471 POPTR_596773 POPTR_743875 POPTR_920707
VVI: 
100243718 100245514 100255051
OSA: 
4327743 4330669 4335633 4340644 4345610
DOSA: 
Os01t0920400-01(Os01g0920400) Os02t0738900-01(Os02g0738900) Os04t0381000-01(Os04g0381000) Os06t0247800-01(Os06g0247800) Os08t0425100-01(Os08g0425100)
BDI: 
100821570 100821795 100830643 100846078
SBI: 
SORBI_03g044010(SORBIDRAFT_03g044010) SORBI_04g028510(SORBIDRAFT_04g028510) SORBI_07g020670(SORBIDRAFT_07g020670) SORBI_10g008870(SORBIDRAFT_10g008870)
ZMA: 
100279900 100286124
SMO: 
SELMODRAFT_119205 SELMODRAFT_171046 SELMODRAFT_437242 SELMODRAFT_439053 SELMODRAFT_449094 SELMODRAFT_77824
PPP: 
PHYPADRAFT_105325 PHYPADRAFT_121955 PHYPADRAFT_124455 PHYPADRAFT_134169 PHYPADRAFT_142116 PHYPADRAFT_169834
CRE: 
CHLREDRAFT_195430(DRP3)
VCN: 
VOLCADRAFT_115648(drp3)
OLU: 
OSTLU_29011
OTA: 
Ot01g03700
CME: 
CME019C
SCE: 
YLL001W(DNM1)
AGO: 
AGOS_AAL174C
ERC: 
Ecym_8274
KLA: 
KLLA0F12892g
LTH: 
KLTH0B03058g
PPA: 
PAS_chr3_0751
VPO: 
Kpol_2002p110
ZRO: 
ZYRO0B10098g
CGR: 
CAGL0D05808g
NCS: 
NCAS_0A01180(NCAS0A01180)
NDI: 
NDAI_0C02270(NDAI0C02270)
TPF: 
TPHA_0E02980(TPHA0E02980)
TBL: 
TBLA_0H02850(TBLA0H02850)
TDL: 
TDEL_0E04110(TDEL0E04110)
KAF: 
KAFR_0H03650(KAFR0H03650)
DHA: 
DEHA2C11946g
PIC: 
PICST_29756
PGU: 
PGUG_01137
LEL: 
LELG_02253
CAL: 
CaO19.6987(DNM1)
CTP: 
CTRG_02129
CDU: 
CD36_85490
COT: 
CORT_0D06950
YLI: 
YALI0F16379g
CLU: 
CLUG_04157
NCR: 
NCU09808
SMP: 
SMAC_08468
PAN: 
PODANSg5973
TTT: 
THITE_2113283
MTM: 
MYCTH_2296480
MGR: 
MGG_06361
FGR: 
FG01320.1
NHE: 
NECHADRAFT_65401
VAL: 
VDBG_05841
SSL: 
SS1G_01608
BFU: 
BC1G_02461
ANI: 
AN8874.2
NFI: 
NFIA_096530
AFM: 
AFUA_8G02840
AOR: 
AOR_1_1320024(AO090010000776)
ANG: 
ANI_1_896034(An03g06950)
AFV: 
AFLA_122710
ACT: 
ACLA_042880
PCS: 
Pc16g01180
CIM: 
CIMG_02293
CPW: 
CPC735_039510
PBL: 
PAAG_01761
URE: 
UREG_01444
ABE: 
ARB_06579
TVE: 
TRV_07295
AJE: 
HCAG_01882
PNO: 
SNOG_15180
PTE: 
PTT_08270
ZTR: 
MYCGRDRAFT_107730
TML: 
GSTUM_00001624001
SPO: 
SPBC12C2.08(dnm1)
CNE: 
CNC01680
CNB: 
CNBC5580
CGI: 
CGB_C2490C
LBC: 
LACBIDRAFT_244551
CCI: 
CC1G_04008
SCM: 
SCHCODRAFT_53713
UMA: 
UM05378.1
MGL: 
MGL_2866
PGR: 
PGTG_03834
ECU: 
ECU10_1700i
EIN: 
Eint_101670
EHE: 
EHEL_101740
NCE: 
NCER_101752
MBR: 
MONBRDRAFT_28892 MONBRDRAFT_34545
NGR: 
NAEGRDRAFT_77733 NAEGRDRAFT_82955
DDI: 
DDB_G0277849(dymA)
DPP: 
DICPUDRAFT_51521
EHI: 
EHI_013180(282.t00012)
EDI: 
EDI_298540
PFA: 
PF10_0368 PF11_0465(dyn1)
PFD: 
PFDG_03503
PFH: 
PFHG_02513
PYO: 
PY04073
PCB: 
PC000555.02.0
PBE: 
PB000789.03.0
PKN: 
PKH_062180
PVX: 
PVX_110885
PCY: 
PCYB_063120
TAN: 
TA11580
TPV: 
TP02_0143
BBO: 
BBOV_III010040(17.m07872)
CPV: 
cgd2_3400
TGO: 
TGME49_067800
TET: 
TTHERM_00160990 TTHERM_00218320 TTHERM_00486790 TTHERM_01194750 TTHERM_01194760 TTHERM_01194780 TTHERM_01194810 TTHERM_02046520
PTM: 
GSPATT00013774001 GSPATT00034002001
TBR: 
Tb927.3.4720(Tb03.48K5.290) Tb927.3.4760(Tb03.48K5.360)
TCR: 
508153.20
LMA: 
LMJF_29_2200
LIF: 
LINJ_29_2310
LDO: 
LDBPK_292310
LMI: 
LMXM_08_29_2200
LBZ: 
LBRM_29_2180
GLA: 
GL50803_14373
TVA: 
TVAG_047650 TVAG_298300
PTI: 
PHATRDRAFT_54751(DYN1)
TPS: 
THAPS_35266(DYN1)
PIF: 
PITG_00183
 » show all
Taxonomy
Reference
1  [PMID:8939066]
  Authors
Warnock DE, Schmid SL.
  Title
Dynamin GTPase, a force-generating molecular switch.
  Journal
Bioessays. 18 (1996) 885-93.
  Organism
Rattus norvegicus [GN:rno], Drosophila sp.
Reference
2  [PMID:9116759]
  Authors
McClure SJ, Robinson PJ.
  Title
Dynamin, endocytosis and intracellular signalling (review).
  Journal
Mol. Membr. Biol. 13 (1996) 189-215.
Reference
3  [PMID:9531551]
  Authors
Oh P, McIntosh DP, Schnitzer JE.
  Title
Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.
  Journal
J. Cell. Biol. 141 (1998) 101-14.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
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