KEGG   ENZYME: 3.6.5.6Help
Entry
EC 3.6.5.6                  Enzyme                                 

Name
tubulin GTPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on GTP to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
GTP phosphohydrolase (microtubule-releasing)
Reaction(IUBMB)
GTP + H2O = GDP + phosphate [RN:R00335]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
H2O [CPD:C00001]
Product
GDP [CPD:C00035];
phosphate [CPD:C00009]
Comment
An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.
History
EC 3.6.5.6 created 2000 as EC 3.6.1.51, transferred 2003 to EC 3.6.5.6
Reference
1  [PMID:9312004]
  Authors
Yu XC, Margolin W.
  Title
Ca2+-mediated GTP-dependent dynamic assembly of bacterial cell division protein FtsZ into asters and polymer networks in vitro.
  Journal
EMBO. J. 16 (1997) 5455-63.
  Organism
Escherichia coli
Reference
2  [PMID:10446175]
  Authors
Tian G, Bhamidipati A, Cowan NJ, Lewis SA.
  Title
Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer.
  Journal
J. Biol. Chem. 274 (1999) 24054-8.
  Organism
Bos taurus, Mus musculus
Reference
3  [PMID:10224115]
  Authors
Roychowdhury S, Panda D, Wilson L, Rasenick MM.
  Title
G protein alpha subunits activate tubulin GTPase and modulate microtubule polymerization dynamics.
  Journal
J. Biol. Chem. 274 (1999) 13485-90.
  Organism
Bos taurus, Ovis aries
Other DBs
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IUBMB Enzyme Nomenclature: 
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BRENDA, the Enzyme Database: 

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