| Entry |
|
|---|
| Name |
tubulin GTPase |
|---|
| Class |
Hydrolases;
Acting on acid anhydrides;
Acting on GTP to facilitate cellular and subcellular movement
 |
|---|
| Sysname |
GTP phosphohydrolase (microtubule-releasing) |
|---|
| Reaction(IUBMB) |
GTP + H2O = GDP + phosphate [RN:R00335] |
|---|
| Reaction(KEGG) |
R00335
 |
|---|
| Substrate |
GTP [CPD:C00044];
H2O [CPD:C00001] |
|---|
| Product |
GDP [CPD:C00035];
phosphate [CPD:C00009] |
|---|
| Comment |
An intrinsic activity of alpha-tubulin involved in tubulin folding,
division plane formation in prokaryotic cells and others. |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:9312004]
Yu XC, Margolin W.
Ca2+-mediated GTP-dependent dynamic assembly of bacterial cell
division protein FtsZ into asters and polymer networks in vitro.
EMBO. J. 16 (1997) 5455-63.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10446175]
Tian G, Bhamidipati A, Cowan NJ, Lewis SA.
Tubulin folding cofactors as GTPase-activating proteins. GTP
hydrolysis and the assembly of the alpha/beta-tubulin heterodimer.
J. Biol. Chem. 274 (1999) 24054-8.
Bos taurus [GN:bta], Mus musculus [GN:mmu] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10224115]
Roychowdhury S, Panda D, Wilson L, Rasenick MM.
G protein alpha subunits activate tubulin GTPase and modulate
microtubule polymerization dynamics.
J. Biol. Chem. 274 (1999) 13485-90.
Bos taurus [GN:bta], Ovis aries |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.6.5.6
IUBMB Enzyme Nomenclature: 3.6.5.6
ExPASy - ENZYME nomenclature database: 3.6.5.6
BRENDA, the Enzyme Database: 3.6.5.6 |
|---|
