KEGG   ENZYME: 3.7.1.13Help
Entry
EC 3.7.1.13                 Enzyme                                 

Name
2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase;
CarC
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase
Reaction(IUBMB)
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = anthranilate + (2E)-2-hydroxypenta-2,4-dienoate
Reaction(KEGG)
(other) R05365
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Substrate
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate;
H2O [CPD:C00001]
Product
anthranilate [CPD:C00108];
(2E)-2-hydroxypenta-2,4-dienoate
Comment
This enzyme catalyses the third step in the aerobic degradation pathway of carbazole. The effect of the presence of an amino group or hydroxyl group at the 2-position of the substrate is small. The enzyme has no cofactor requirement [2].
History
EC 3.7.1.13 created 2010
Pathway
Dioxin degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K15756  
2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase
Genes
PSD: 
PRE: 
TTU: 
CYQ: 
CZA: 
RBU: 
SSAN: 
BTS: 
Taxonomy
Reference
1  [PMID:12619671]
  Authors
Nojiri H, Taira H, Iwata K, Morii K, Nam JW, Yoshida T, Habe H, Nakamura S, Shimizu K, Yamane H, Omori T
  Title
Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10.
  Journal
Biosci. Biotechnol. Biochem. 67 (2003) 36-45.
  Sequence
Reference
2  [PMID:12651123]
  Authors
Riddle RR, Gibbs PR, Willson RC, Benedik MJ
  Title
Purification and properties of 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole.
  Journal
Protein. Expr. Purif. 28 (2003) 182-9.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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