| Entry |
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| Name |
2-hydroxy-6-oxonona-2,4-dienedioate hydrolase;
mhpC (gene name)
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| Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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| Sysname |
(2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase
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| Reaction(IUBMB) |
(1) (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + succinate [RN: R02603];
(2) (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate [RN: R06789]
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| Reaction(KEGG) |
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| Substrate |
(2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate [CPD: C04479];
H2O [CPD: C00001];
(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate [CPD: C12624]
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| Product |
(2Z)-2-hydroxypenta-2,4-dienoate;
succinate [CPD: C00042];
fumarate [CPD: C00122]
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| Comment |
This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation. The first step of the enzyme mechanism involves a reversible keto-enol tautomerization [4].
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| History |
EC 3.7.1.14 created 2011, modified 2012
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| Pathway |
| Phenylalanine metabolism | | Microbial metabolism in diverse environments |
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| Orthology |
| 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase |
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| Genes |
ECO: | | ECJ: | | ECD: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | EOK: | | ELR: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ELO: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EDH: | | EDJ: | | ENA: | | EUN: | | ELW: | | ELL: | | ELP: | | EBL: | | EBE: | | ECOA: | | ECOL: | | ECOJ: | | ECOO: | | ECOH: | | ECOS: | | SHQ: | | KPN: | | KPU: | | KPM: | | KPP: | | KPK: | | KPH: | | KPZ: | | KPV: | | KPW: | | KPY: | | KPG: | | KPC: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPR: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KPNE: | | KPNU: | | KVA: | | KVD: | | KVQ: | | KOX: | | KOE: | | KOY: | | KOK: | | KOC: | | KOM: | | KQU: | | CFD: | | CIF: | | EBT: | | ROR: | | PGE: | | EBF: | | PLU: | | PAY: | | VEJ: | | VFU: | | PPW: | | PPUH: | | PSV: | | AVN: | | AVL: | | AVD: | | REU: | | CNC: | | BVI: | | BVE: | | BCEW: | | BGE: | | BUK: | | BXE: | | BPH: | | PPNO: | | PPNM: | | PRB: | | PSPU: | | PAPI: | | PVE: | | POX: | | PFG: | | BBR: | | BAV: | | DAR: | | AZO: | | XAU: | | SWI: | | MPA: | | MAO: | | MAV: | | MIT: | | MIA: | | MIR: | | MID: | | MYO: | | MSM: | | MSG: | | MVA: | | MGI: | | MSP: | | MCB: | | MSA: | | MAB: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MLI: | | MKN: | | ASD: | | CAZ: | | RHA: | | ROP: | | ROA: | | REQ: | | RPY: | | GBR: | | SCB: | | SVL: | | SRC: | | ICA: | | NCA: | | TCU: | | FRE: | | FRI: | | NML: | | AMD: | | AMN: | | AMM: | | AMZ: | | PDX: | | AFS: | | TRO: | |
» show all
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| Reference |
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| Authors |
Burlingame R, Chapman PJ. |
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| Title |
Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. |
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| Journal |
J. Bacteriol. 155 (1983) 113-21. |
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| Reference |
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| Authors |
Burlingame RP, Wyman L, Chapman PJ |
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| Title |
Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. |
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| Journal |
J. Bacteriol. 168 (1986) 55-64. |
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| Reference |
3 |
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| Authors |
Lam, W. W. Y and Bugg, T. D. H. |
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| Title |
Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage. |
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| Journal |
J. Chem. Soc., Chem. Commun. 10 (1994) 1163-1164. |
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| Reference |
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| Authors |
Lam WW, Bugg TD |
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| Title |
Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase. |
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| Journal |
Biochemistry. 36 (1997) 12242-51. |
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| Sequence |
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| Reference |
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| Authors |
Ferrandez A, Garcia JL, Diaz E |
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| Title |
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12. |
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| Journal |
J. Bacteriol. 179 (1997) 2573-81. |
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| Sequence |
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| Reference |
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| Authors |
Diaz E, Ferrandez A, Garcia JL. |
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| Title |
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. |
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| Journal |
J. Bacteriol. 180 (1998) 2915-23. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: |
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