KEGG   ENZYME: 3.7.1.19Help
Entry
EC 3.7.1.19                 Enzyme                                 

Name
2,6-dihydroxypseudooxynicotine hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase
Reaction(IUBMB)
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate [RN:R07515]
Reaction(KEGG)
Substrate
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one [CPD:C15986];
H2O [CPD:C00001]
Product
2,6-dihydroxypyridine [CPD:C03056];
4-methylaminobutanoate
Comment
The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation.
History
EC 3.7.1.19 created 2012
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Orthology
K19188  
2,6-dihydroxypseudooxynicotine hydrolase
Genes
ROP: 
ROA: 
NCA: 
Taxonomy
Reference
1  [PMID:5835946]
  Authors
Gherna RL, Richardson SH, Rittenberg SC.
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J. Biol. Chem. 240 (1965) 3669-74.
Reference
2  [PMID:16321959]
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J. Bacteriol. 187 (2005) 8516-9.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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