KEGG   ENZYME: 3.8.1.11Help
Entry
EC 3.8.1.11                 Enzyme                                 

Name
2-haloacid dehalogenase (configuration-retaining);
2-haloalkanoic acid dehalogenase;
2-haloalkanoid acid halidohydrolase;
DL-2-haloacid dehalogenase;
DL-DEXr
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
(S)-2-haloacid dehalogenase (configuration-retaining)
Reaction(IUBMB)
(1) (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide [RN:R07309];
(2) (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide [RN:R07310]
Reaction(KEGG)
Substrate
(S)-2-haloacid [CPD:C02103];
H2O [CPD:C00001];
(R)-2-haloacid [CPD:C15564]
Product
(S)-2-hydroxyacid [CPD:C15565];
halide [CPD:C00462];
(R)-2-hydroxyacid [CPD:C02489]
Comment
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)]
History
EC 3.8.1.11 created 2003
Reference
1  [PMID:7142958]
  Authors
Weightman AJ, Weightman AL, Slater JH.
  Title
Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms.
  Journal
J. Gen. Microbiol. 128 (1982) 1755-62.
Reference
2
  Authors
Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N.
  Title
Bacterial 2-haloacid dehalogenases: Structures and catalytic properties.
  Journal
Pure Appl. Chem. 68 (1996) 2097-2103.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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