| Entry |
|
|---|
| Name |
(S)-2-haloacid dehalogenase;
2-haloacid dehalogenase[ambiguous];
2-haloacid halidohydrolase [ambiguous][ambiguous];
2-haloalkanoic acid dehalogenase;
2-haloalkanoid acid halidohydrolase;
2-halocarboxylic acid dehalogenase II;
DL-2-haloacid dehalogenase[ambiguous];
L-2-haloacid dehalogenase;
L-DEX |
|---|
| Class |
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
 |
|---|
| Sysname |
(S)-2-haloacid halidohydrolase |
|---|
| Reaction(IUBMB) |
(S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide [RN:R03830] |
|---|
| Reaction(KEGG) |
R03830 > R05287
 |
|---|
| Substrate |
(S)-2-haloacid [CPD:C02103];
H2O [CPD:C00001] |
|---|
| Product |
(R)-2-hydroxyacid [CPD:C02489];
halide [CPD:C00462] |
|---|
| Comment |
Acts on acids of short chain lengths, C2 to C4, with inversion of
configuration at C-2. [See also EC 3.8.1.9 (R)-2-haloacid
dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase
(configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase
(configuration-retaining)] |
|---|
| Pathway |
PATH: ec00361 gamma-Hexachlorocyclohexane degradation
PATH: ec00631 1,2-Dichloroethane degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01560 2-haloacid dehalogenase |
|---|
| Genes |
NCR: NCU03617
MGR: MGG_01809
ANI: AN5830.2 AN7918.2
AFM: AFUA_2G07750 AFUA_5G14640 AFUA_8G05870
AOR: AO090001000019 AO090003001435 AO090011000921
ANG: An05g00340 An09g00420
UMA: UM02622.1
ECA: ECA3957
PAE: PA0810
PAU: PA14_53790
PST: PSPTO_0247(dehII)
PSB: Psyr_0159 Psyr_1791
PSP: PSPPH_1747(dehII1) PSPPH_5028(dehII2)
PFO: Pfl01_3802
PAR: Psyc_1396
PCR: Pcryo_0968
SFR: Sfri_2142 Sfri_3956
ILO: IL1575(hadL)
CPS: CPS_3130(dehII)
PHA: PSHAa1832
PAT: Patl_0275
AMC: MADE_00421
PIN: Ping_2901
HHA: Hhal_0171
CSA: Csal_2713
ABO: ABO_1537(dhlB)
MMW: Mmwyl1_3076
CVI: CV_0864
RSO: RSc1362
RPI: Rpic_1235
RPF: Rpic12D_1301
REU: Reut_A1952 Reut_B5659 Reut_B5662
REH: H16_A2218
RME: Rmet_1389
CTI: RALTA_A1761
BMA: BMA1589(dheII) BMAA0223(dehII) BMAA0509
BMV: BMASAVP1_0669 BMASAVP1_1404(dehII-1) BMASAVP1_A2091(dehII-2)
BML: BMA10229_0965 BMA10229_1601(dehII-1) BMA10229_A3221(dehII-2)
BMN: BMA10247_1364(dehII-2) BMA10247_A0260(dehII-1) BMA10247_A1935
BPS: BPSL2191 BPSL3068 BPSS1869
BPM: BURPS1710b_2616(dehII) BURPS1710b_3596 BURPS1710b_A0962(dehII)
BPL: BURPS1106A_2527(dehII) BURPS1106A_3607 BURPS1106A_A2536(dehII)
BPD: BURPS668_2474(dehII) BURPS668_3582 BURPS668_A2679
BURPS668_A2680(dehII)
BPR: GBP346_A2598(dehII)
BTE: BTH_I1995(dehII-1) BTH_I2925 BTH_II0507(dehII-2)
BVI: Bcep1808_0497 Bcep1808_1957 Bcep1808_6425
BUR: Bcep18194_A3603 Bcep18194_A5360 Bcep18194_B2027
BCN: Bcen_2588 Bcen_4315 Bcen_6026 Bcen_6447
BCH: Bcen2424_0516 Bcen2424_2051 Bcen2424_4051 Bcen2424_6682
BCM: Bcenmc03_0488 Bcenmc03_2070 Bcenmc03_3474
BCJ: BCAL2121
BAM: Bamb_0420 Bamb_2083 Bamb_3446 Bamb_6423
BAC: BamMC406_1953
BMU: Bmul_1226
BMJ: BMULJ_02021
BXE: Bxe_A0441 Bxe_A1648 Bxe_B1493 Bxe_C0774
BPH: Bphy_1371
BPY: Bphyt_5153
BGL: bglu_2p0930
PNU: Pnuc_1324 Pnuc_2046
PNE: Pnec_1768
BPE: BP2017
BPA: BPP2397 BPP4207
BBR: BB1847 BB4677
BPT: Bpet4904
RFR: Rfer_3582
POL: Bpro_0056 Bpro_0530 Bpro_4516 Bpro_5186
PNA: Pnap_3684
AAV: Aave_2185 Aave_3493 Aave_3757
AJS: Ajs_1108
VEI: Veis_3206
DIA: Dtpsy_1029
VAP: Vapar_0453
MPT: Mpe_A0158
HAR: HEAR0667(hadL)
MMS: mma_0898(dhlB)
LCH: Lcho_4165
EBA: ebA812
AZO: azo0216(hadL)
APP: CAP2UW1_2825
GLO: Glov_3726
GEO: Geob_0333
ADE: Adeh_3811
ACP: A2cp1_3955
AFW: Anae109_1202
ANK: AnaeK_3868
SCL: sce0923(had)
PUB: SAR11_0137(dhlB)
MLO: mll7522 mll7634 mlr7041
MES: Meso_0764 Meso_0860
SME: SMa1851 SMc00081
SMD: Smed_5598
ATU: Atu0797 Atu3405(hadL)
ATC: AGR_C_1458 AGR_L_2834
RET: RHE_CH00996(ypch00330) RHE_PF00342(ypf00173)
REC: RHECIAT_PC0000546
RLE: RL1077 pRL120620
RLT: Rleg2_4415
RLG: Rleg_5015
RHI: NGR_b06290
BME: BMEI1368 BMEI1443
BMF: BAB1_0517 BAB1_0590
BMB: BruAb1_0514 BruAb1_0587
BMC: BAbS19_I05510
BMS: BR0492 BR0565
BMT: BSUIS_A0593(dehII)
BOV: BOV_0566(dehII)
BCS: BCAN_A0578(dehII)
BMR: BMI_I564
OAN: Oant_2700
BJA: blr4364 blr7560(dhlB)
BRA: BRADO1532 BRADO3574
BBT: BBta_1654 BBta_1918 BBta_3998
RPA: RPA2507 RPA4199
RPB: RPB_2963
RPC: RPC_2814
RPD: RPD_2498
RPE: RPE_2935
RPT: Rpal_4679
OCA: OCAR_5074(dehII)
XAU: Xaut_0978
MEX: Mext_3296
MEA: Mex_1p3510
MDI: METDI4087
MRD: Mrad2831_2564 Mrad2831_4499
MET: M446_5307 M446_5721
MPO: Mpop_3496
MCH: Mchl_3619
MNO: Mnod_1452
BID: Bind_0461
MSL: Msil_3008
SIL: SPO2473 SPOA0437(dehII)
SIT: TM1040_2669 TM1040_3570
JAN: Jann_0053 Jann_1658
RDE: RD1_0322 RD1_3929(deh)
DSH: Dshi_2700(dhlB)
HBA: Hbal_1412
NAR: Saro_2947
ACR: Acry_1485 Acry_3098
GDI: GDI_0459
GDJ: Gdia_1547
MAG: amb2538
BSU: BSU07330(yfnB)
BAN: BA3392 BA5658
BAR: GBAA3392 GBAA5658
BAA: BA_0516 BA_3891
BAT: BAS3145 BAS5260
BCE: BC3334 BC5408
BCA: BCE_3362 BCE_5537
BCZ: BCZK3039 BCZK5105
BTK: BT9727_3132 BT9727_5088
BTL: BALH_3014 BALH_4908
BLI: BL02712(yfnB)
BLD: BLi00219(yfnB)
SSP: SSP0367
SCA: Sca_2091
ESI: Exig_2796
EAT: EAT1b_1237
LLC: LACR_0249 LACR_1604
LLM: llmg_0254(hadL)
LPL: lp_2835
LSA: LSA0155 LSA0447
LSL: LSL_0676
LBR: LVIS_2192
CAC: CAC1776
CTC: CTC01925
DSY: DSY1360
MPA: MAP1728c(yfnB)
MAV: MAV_2690(dehII)
MSM: MSMEG_0115(dehII) MSMEG_3450(dehII) MSMEG_4059
MUL: MUL_1268
MVA: Mvan_0108
MGI: Mflv_0739
MAB: MAB_2863
MMC: Mmcs_0093
MKM: Mkms_0102
MJL: Mjls_0083
RHA: RHA1_ro00230
SCO: SCO0404(SCF51.03) SCO3446(SCE46.03c)
SMA: SAV_737
SGR: SGR_2516
NCA: Noca_1645
SEN: SACE_2965(dhlB) SACE_4364 SACE_4734(hadL)
RXY: Rxyl_0508 Rxyl_1673
LIL: LA0080 LA0537 LA1476
LIC: LIC12279 LIC13027
LBJ: LBJ_0977
LBL: LBL_2056
ABA: Acid345_4292
SUS: Acid_5126
SRU: SRU_1260(dehII)
GFO: GFO_3460
FJO: Fjoh_0002
RBA: RB4567(chd1)
CPC: Cpar_1536
CPB: Cphamn1_2254
PVI: Cvib_0311
PAA: Paes_2026
CTS: Ctha_1071
RRS: RoseRS_3515
RCA: Rcas_0599
CAU: Caur_2883
CHL: Chy400_3119
TRO: trd_A0854(dehII)
HMA: rrnAC0241(hadL)
HWA: HQ1755A(hadL)
HLA: Hlac_2517
PHO: PH0459
PAB: PAB1316
PFU: PF0463
TKO: TK0058
SSO: SSO0726 SSO1896 SSO2028 SSO2159
STO: ST0436 ST2145 ST2620
SAI: Saci_0018 Saci_0239 Saci_0302 Saci_0602
MSE: Msed_0732
 |
|---|
| Structures |
PDB: 1AQ6 1JUD 1QH9 1QQ5 1QQ6 1QQ7 1ZRM 1ZRN 2NO4 2NO5
2W11 3BJX |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5635785]
Goldman P, Milne GW, Keister DB.
Carbon-halogen bond cleavage. 3. Studies on bacterial
halidohrolases.
J. Biol. Chem. 243 (1968) 428-34.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
|
2
Motosugi, M., Esaki, N. and Soda, K.
Preparation and properties of 2-halo acid dehalogenase from
Pseudomonas putida.
Agric. Biol. Chem. 46 (1982) 837-838. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6873881]
Klages U, Krauss S, Lingens F.
2-Haloacid dehalogenase from a 4-chlorobenzoate-degrading
Pseudomonas spec. CBS 3.
Hoppe. Seylers. Z. Physiol. Chem. 364 (1983) 529-35.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:8607850]
Diez A, Prieto MI, Alvarez MJ, Bautista JM, Garrido J, Puyet A.
Improved catalytic performance of a 2-haloacid dehalogenase from
Azotobacter sp. by ion-exchange immobilisation.
Biochem. Biophys. Res. Commun. 220 (1996) 828-33.
Azotobacter sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:1772590]
Morsberger FM, Muller R, Otto MK, Lingens F, Kulbe KD.
Purification and characterization of 2-halocarboxylic acid
dehalogenase II from Pseudomonas spec. CBS 3.
Biol. Chem. Hoppe. Seyler. 372 (1991) 915-22.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:9425247]
Kohler R, Brokamp A, Schwarze R, Reiting RH, Schmidt FR.
Characteristics and DNA-sequence of a cryptic haloalkanoic acid
dehalogenase from Agrobacterium tumefaciens RS5.
Curr. Microbiol. 36 (1998) 96-101.
Agrobacterium tumefaciens |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:7103659]
Motosugi K, Esaki N, Soda K.
Bacterial assimilation of D- and L-2-chloropropionates and
occurrence of a new dehalogenase.
Arch. Microbiol. 131 (1982) 179-83.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
|
8
Kurihara, T., Esaki, N. and Soda, K.
Bacterial 2-haloacid dehalogenases: structures and reaction
mechanisms.
J. Mol. Catal., B Enzym. 10 (2000) 57-65. |
|---|
Reference
Authors
Title
Journal
|
9
Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi,
M., Tsunasawa, S. and Esaki, N.
Bacterial 2-haloacid dehalogenases: Structures and catalytic
properties.
Pure Appl. Chem. 68 (1996) 2097-2103. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.8.1.2
IUBMB Enzyme Nomenclature: 3.8.1.2
ExPASy - ENZYME nomenclature database: 3.8.1.2
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.2
BRENDA, the Enzyme Database: 3.8.1.2
CAS: 37289-39-7 |
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